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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

INSIG1  -  insulin induced gene 1

Gallus gallus

 
 
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Disease relevance of RCJMB04_1d1

  • Plasma growth hormone was determined in a group of scoliotic girls by double antibody radioimmunoassay under the following conditions: 1) Insulin induced hypoglycemia, 2) glucose tolerance test, 3) exercise [1].
 

High impact information on RCJMB04_1d1

  • Insulin-induced glycogen stores were broken down following removal of the hormone, even when glucose was present in great excess, indicating that the cells require insulin to maintain as well as build up maximal levels of glycogen [2].
  • Insulin induced activity in liver and in heart muscle of normal as well as of pyridoxine-deficient chickens, while in the pancreas an induction was observed in the control animals and a decrease in the deficient ones [3].

References

  1. Growth hormone and somatomedin A in girls with adolescent idiopathic scoliosis. Willner, S., Nilsson, K.O., Kastrup, K., Bergstrand, C.G. Acta paediatrica Scandinavica. (1976) [Pubmed]
  2. Insulin, not glucose, controls hepatocellular glycogen deposition. A re-evaluation of the role of both agents in cultured liver cells. Parkes, J.L., Grieninger, G. J. Biol. Chem. (1985) [Pubmed]
  3. S-Adenosylmethionine decarboxylase in liver, heart and pancreas of pyridoxine-deficient chickens. Grillo, M.A., Bedino, S. Ital. J. Biochem. (1977) [Pubmed]
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