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Gene Review

Insig1  -  insulin induced gene 1

Rattus norvegicus

Synonyms: Cl-6, INSIG-1, Immediate-early protein CL-6, Insulin-induced gene 1 protein, Insulin-induced growth response protein CL-6
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Disease relevance of Insig1


High impact information on Insig1


Chemical compound and disease context of Insig1


Biological context of Insig1


Anatomical context of Insig1


Associations of Insig1 with chemical compounds


Regulatory relationships of Insig1


Other interactions of Insig1


Analytical, diagnostic and therapeutic context of Insig1


  1. Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms. Nickenig, G., Röling, J., Strehlow, K., Schnabel, P., Böhm, M. Circulation (1998) [Pubmed]
  2. Skeletal malformations in rat offspring. Long-term effect of maternal insulin-induced hypoglycemia during organogenesis. Tanigawa, K., Kawaguchi, M., Tanaka, O., Kato, Y. Diabetes (1991) [Pubmed]
  3. Insulin-induced increase in insulin binding to cultured chondrosarcoma chondrocytes. Stevens, R.L., Austen, K.F., Nissley, S.P. J. Biol. Chem. (1983) [Pubmed]
  4. Insulin-induced receptor regulation in cultured Zajdela rat hepatoma cells and relationship to the stimulation of glycogen synthesis. Capeau, J., Flaig-Staedel, C., Beck, J.P., Picard, J. Endocrinology (1982) [Pubmed]
  5. Effects of hypoglycemia on rat brain polyribosome sedimentation pattern. Ulovec, Z., Narancsik, P., Gamulin, S. J. Neurochem. (1985) [Pubmed]
  6. Insulin-induced cortical actin remodeling promotes GLUT4 insertion at muscle cell membrane ruffles. Tong, P., Khayat, Z.A., Huang, C., Patel, N., Ueyama, A., Klip, A. J. Clin. Invest. (2001) [Pubmed]
  7. Insulin-induced activation of glycerol-3-phosphate acyltransferase by a chiro-inositol-containing insulin mediator is defective in adipocytes of insulin-resistant, type II diabetic, Goto-Kakizaki rats. Farese, R.V., Standaert, M.L., Yamada, K., Huang, L.C., Zhang, C., Cooper, D.R., Wang, Z., Yang, Y., Suzuki, S., Toyota, T. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  8. Dietary cod protein restores insulin-induced activation of phosphatidylinositol 3-kinase/Akt and GLUT4 translocation to the T-tubules in skeletal muscle of high-fat-fed obese rats. Tremblay, F., Lavigne, C., Jacques, H., Marette, A. Diabetes (2003) [Pubmed]
  9. Insulin rescues retinal neurons from apoptosis by a phosphatidylinositol 3-kinase/Akt-mediated mechanism that reduces the activation of caspase-3. Barber, A.J., Nakamura, M., Wolpert, E.B., Reiter, C.E., Seigel, G.M., Antonetti, D.A., Gardner, T.W. J. Biol. Chem. (2001) [Pubmed]
  10. Tumor necrosis factor alpha inhibits insulin-induced mitogenic signaling in vascular smooth muscle cells. Goetze, S., Kintscher, U., Kawano, H., Kawano, Y., Wakino, S., Fleck, E., Hsueh, W.A., Law, R.E. J. Biol. Chem. (2000) [Pubmed]
  11. Insulin-induced hypoglycemia activates the release of adrenocorticotropin predominantly via central and propranolol insensitive mechanisms. Jezová, D., Kvetnanský, R., Kovács, K., Oprsalová, Z., Vigas, M., Makara, G.B. Endocrinology (1987) [Pubmed]
  12. 2-Amino-7-phosphonoheptanoic acid inhibits insulin-induced convulsions and striatal aspartate accumulation in rats with frontal cortical ablation. Chapman, A.G., Engelsen, B., Meldrum, B.S. J. Neurochem. (1987) [Pubmed]
  13. Regional acetylcholine metabolism in brain during acute hypoglycemia and recovery. Ghajar, J.B., Gibson, G.E., Duffy, T.E. J. Neurochem. (1985) [Pubmed]
  14. Hypothalamus-brain stem circuitry responsible for vagal efferent signaling to the pancreas evoked by hypoglycemia in rat. Wu, X., Gao, J., Yan, J., Owyang, C., Li, Y. J. Neurophysiol. (2004) [Pubmed]
  15. Insulin-induced hypoglycemia decreases luteinizing hormone secretion in the castrated male rat: involvement of opiate peptides. Goubillon, M.L., Thalabard, J.C. Neuroendocrinology (1996) [Pubmed]
  16. Dual regulation of glycogen synthase kinase-3beta by the alpha1A-adrenergic receptor. Ballou, L.M., Tian, P.Y., Lin, H.Y., Jiang, Y.P., Lin, R.Z. J. Biol. Chem. (2001) [Pubmed]
  17. Desensitization of hepatoma cells to insulin action. Evidence for a post-receptor mechanism. Heaton, J.H., Gelehrter, T.D. J. Biol. Chem. (1981) [Pubmed]
  18. Insulin stimulates hydrolysis of plasmanylinositol-glycan and phosphatidylinositol-glycan in rat adipocytes. Insulin-induced generation of inositol glycan, alkylacylglycerol, and diacylglycerol. Suzuki, S., Taneda, Y., Hirai, S., Satoh, Y., Toyota, T. Diabetes (1993) [Pubmed]
  19. Insulin induces expression of adenosine kinase gene in rat lymphocytes by signaling through the mitogen-activated protein kinase pathway. Pawelczyk, T., Sakowicz, M., Podgorska, M., Szczepanska-Konkel, M. Exp. Cell Res. (2003) [Pubmed]
  20. Chronic nicotine exposure enhances insulin-induced mitogenic signaling via up-regulation of alpha7 nicotinic receptors in isolated rat aortic smooth muscle cells. Wada, T., Naito, M., Kenmochi, H., Tsuneki, H., Sasaoka, T. Endocrinology (2007) [Pubmed]
  21. Insulin-induced rapid decrease of a major protein in fat cell plasma membranes. Schoenle, E.J., Adams, L.D., Sammons, D.W. J. Biol. Chem. (1984) [Pubmed]
  22. Hemodynamic actions of insulin in rat skeletal muscle: evidence for capillary recruitment. Rattigan, S., Clark, M.G., Barrett, E.J. Diabetes (1997) [Pubmed]
  23. Insulin-induced alterations in insulin binding and insulin action in primary cultures of rat hepatocytes. Amatruda, J.M., Newmeyer, H.W., Chang, C.L. Diabetes (1982) [Pubmed]
  24. Insulin-induced glucose transporter (GLUT1 and GLUT4) translocation in cardiac muscle tissue is mimicked by bradykinin. Rett, K., Wicklmayr, M., Dietze, G.J., Häring, H.U. Diabetes (1996) [Pubmed]
  25. Insulin-induced reduction of membrane receptor concentrations in isolated fat cells and lymphocytes. Independence from receptor occupation and possible relation to proteolytic activity of insulin. Huang, D., Cuatrecasas, P. J. Biol. Chem. (1975) [Pubmed]
  26. Insulin-induced redistribution of GLUT4 glucose carriers in the muscle fiber. In search of GLUT4 trafficking pathways. Zorzano, A., Muñoz, P., Camps, M., Mora, C., Testar, X., Palacín, M. Diabetes (1996) [Pubmed]
  27. Insulin and oxytocin effects on phosphoinositide metabolism in adipocytes. Augert, G., Exton, J.H. J. Biol. Chem. (1988) [Pubmed]
  28. The mechanism of action of insulin on phospholipid metabolism in rat adipose tissue. Requirement for protein synthesis and a carbohydrate source, and relationship to activation of pyruvate dehydrogenase. Farese, R.V., Farese, R.V., Sabir, M.A., Larson, R.E., Trudeau, W.L., Barnes, D. Diabetes (1984) [Pubmed]
  29. Insulin-induced stimulation of Na+,K(+)-ATPase activity in kidney proximal tubule cells depends on phosphorylation of the alpha-subunit at Tyr-10. Féraille, E., Carranza, M.L., Gonin, S., Béguin, P., Pedemonte, C., Rousselot, M., Caverzasio, J., Geering, K., Martin, P.Y., Favre, H. Mol. Biol. Cell (1999) [Pubmed]
  30. Insulin-induced subcellular redistribution of insulin-like growth factor II receptors in the rat adipose cell. Counterregulatory effects of isoproterenol, adenosine, and cAMP analogues. Lönnroth, P., Appell, K.C., Wesslau, C., Cushman, S.W., Simpson, I.A., Smith, U. J. Biol. Chem. (1988) [Pubmed]
  31. Involvement of neuropeptide Y in glucose sensing in the dorsal hypothalamus of streptozotocin diabetic rats - in vitro and in vivo studies of transmitter release. Gozali, M., Pavia, J.M., Morris, M.J. Diabetologia (2002) [Pubmed]
  32. Central adrenergic suppression augments the insulin and glucagon secretory, and the glycogenolytic responses in streptozotocin-diabetic rats. Dunbar, J.C., Colemen, E.R., Shaffer, L.R., Marzouq, L. Horm. Res. (1991) [Pubmed]
  33. Insulin but not PDGF relies on actin remodeling and on VAMP2 for GLUT4 translocation in myoblasts. Török, D., Patel, N., Jebailey, L., Thong, F.S., Randhawa, V.K., Klip, A., Rudich, A. J. Cell. Sci. (2004) [Pubmed]
  34. Adrenal catecholamine metabolism and myocardial adrenergic receptors in streptozotocin diabetic rats. Bitar, M.S., Koulu, M., Rapoport, S.I., Linnoila, M. Biochem. Pharmacol. (1987) [Pubmed]
  35. Insulin-induced Ca(2+) entry in hepatocytes is important for PI 3-kinase activation, but not for insulin receptor and IRS-1 tyrosine phosphorylation. Benzeroual, K., Pandey, S.K., Srivastava, A.K., van de Werve, G., Haddad, P.S. Biochim. Biophys. Acta (2000) [Pubmed]
  36. Insulin-induced early growth response gene (Egr-1) mediates a short term repression of rat malic enzyme gene transcription. Barroso, I., Santisteban, P. J. Biol. Chem. (1999) [Pubmed]
  37. Insulin-induced dissociation of Sos from Grb2 does not contribute to the down regulation of Ras activation. Corbalan-Garcia, S., Degenhardt, K.R., Bar-Sagi, D. Oncogene (1996) [Pubmed]
  38. Induction of nodular sclerosis by insulin in rat mesangial cells in vitro: studies of collagen. Abrass, C.K., Spicer, D., Raugi, G.J. Kidney Int. (1995) [Pubmed]
  39. Insulin stimulates the translocation of protein kinase C in rat adipocytes. Ishizuka, T., Cooper, D.R., Farese, R.V. FEBS Lett. (1989) [Pubmed]
  40. Grb-2-associated binder-1 is involved in insulin-induced egr-1 gene expression through its phosphatidylinositol 3'-kinase binding site. Harada, S., Esch, G.L., Holgado-Madruga, M., Wong, A.J. DNA Cell Biol. (2001) [Pubmed]
  41. Insulin-induced hyperpolarization as a transducer of insulin action: response within one second. Zierler, K., Rogus, E.M. Trans. Assoc. Am. Physicians (1980) [Pubmed]
  42. Effects of general and selective beta-adrenergic antagonists on insulin-induced cardiac and selected vascular responses in rats. Hauck, C.M., Dunbar, J.C. Acta diabetologica. (1999) [Pubmed]
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