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Gene Review

MTTP  -  microsomal triglyceride transfer protein

Gallus gallus

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Disease relevance of MTTP

  • FAO rat hepatoma cells express L-FABP and MTP and demonstrate the ability to assemble and secrete VLDL [1].
  • In these studies we show that transcriptional co-repression of the two lipid transfer proteins, liver fatty acid-binding protein (L-FABP) and MTP, which cooperatively shunt fatty acids into de novo synthesized glycerolipids and the transfer of lipids into VLDL, respectively, act together to maintain hepatic lipid homeostasis [1].

High impact information on MTTP


  1. Coordinate Transcriptional Repression of Liver Fatty Acid-binding Protein and Microsomal Triglyceride Transfer Protein Blocks Hepatic Very Low Density Lipoprotein Secretion without Hepatosteatosis. Spann, N.J., Kang, S., Li, A.C., Chen, A.Z., Newberry, E.P., Davidson, N.O., Hui, S.T., Davis, R.A. J. Biol. Chem. (2006) [Pubmed]
  2. Lipoprotein receptors in extraembryonic tissues of the chicken. Hermann, M., Mahon, M.G., Lindstedt, K.A., Nimpf, J., Schneider, W.J. J. Biol. Chem. (2000) [Pubmed]
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