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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Clone Cells

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Disease relevance of Clone Cells


High impact information on Clone Cells


Chemical compound and disease context of Clone Cells


Biological context of Clone Cells


Anatomical context of Clone Cells


Associations of Clone Cells with chemical compounds

  • These findings indicate that reversible differentiation into the keratinizing squamous cells of a neoplastic human salivary intercalated duct cell clone occurs in growth medium containing retinoic acid [26].
  • 5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone [27].
  • Dinitrophenol-derivatized beta-glucuronidase (DNP-beta-glucuronidase), a ligand for the mannose receptor, was endocytosed by one population of J774 E clone cells, and mannose-derivatized monoclonal anti-DNP IgG (Man-IgG) was internalized by a second set of cells [28].
  • Dexamethasone treatment of the Jurkat T77 cell clone inhibited the enhancing effect of 12-O-tetradecanoylporbol-13-acetate (TPA) and the calcium ionophore A23187 on the interleukin 2 (IL2) mRNA levels and gene transcription from intact nuclei [29].
  • A protocol has been developed for isolating cholesterol ester-deficient cells from the Chinese hamster ovary cell clone 25-RA [30].

Gene context of Clone Cells

  • To investigate the molecular basis for the sensitivity of WNV to the Oas1b antiviral pathway, we established a stable mouse fibroblastic cell clone that up-regulates Oas1b protein expression under the control of the Tet-Off expression system [31].
  • Stimulation of the human Th cell clone HA-1.70 with either the superantigen staphylococcal enterotoxin B (SEB) or with a specific antigenic peptide resulted in p38 activation and the release of TNF-alpha [32].
  • Either local or systemic administration of CTLA4Ig, a functional antagonist of CD28 binding to B7, could abrogate the bone resorption induced by Th1 clone cells combined with gingival challenge with both Ag and LPS [3].
  • Transfection of human long-form D2R into an LIF-resistant MMQ cell clone restored LIF responsiveness [33].
  • Using 125I-labeled human recombinant IL-2 and 125I-labeled 33B3.1 (a MoAb directed against TAC antigen), we found that expression of both high and low affinity sites was decreased when clone cells were stimulated with D.BLCL in the presence of CsA and exogenous IL-2 (about 50% inhibition in the presence of 500 ng/ml of CsA) [34].

Analytical, diagnostic and therapeutic context of Clone Cells


  1. Induction of the receptor for erythropoietin in murine erythroleukemia cells after dimethyl sulfoxide treatment. Tojo, A., Fukamachi, H., Saito, T., Kasuga, M., Urabe, A., Takaku, F. Cancer Res. (1988) [Pubmed]
  2. Ligand-induced activation of epidermal growth factor receptor in intact rat mammary adenocarcinoma cells without detectable receptor phosphorylation. Lichtner, R.B., Wiedemuth, M., Kittmann, A., Ullrich, A., Schirrmacher, V., Khazaie, K. J. Biol. Chem. (1992) [Pubmed]
  3. Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease. Kawai, T., Eisen-Lev, R., Seki, M., Eastcott, J.W., Wilson, M.E., Taubman, M.A. J. Immunol. (2000) [Pubmed]
  4. The role of IFN-gamma in delayed-type hypersensitivity mediated by Th1 clones. Fong, T.A., Mosmann, T.R. J. Immunol. (1989) [Pubmed]
  5. A human anti-insulin IgG autoantibody apparently arises through clonal selection from an insulin-specific "germ-line" natural antibody template. Analysis by V gene segment reassortment and site-directed mutagenesis. Ichiyoshi, Y., Zhou, M., Casali, P. J. Immunol. (1995) [Pubmed]
  6. Direct T helper-B cell interactions induce an early B cell activation antigen. Crow, M.K., Jover, J.A., Friedman, S.M. J. Exp. Med. (1986) [Pubmed]
  7. The region of mouse mammary tumor virus DNA containing the long terminal repeat includes a long coding sequence and signals for hormonally regulated transcription. Fasel, N., Pearson, K., Buetti, E., Diggelmann, H. EMBO J. (1982) [Pubmed]
  8. Human fetal enterocytes in vitro: modulation of the phenotype by extracellular matrix. Sanderson, I.R., Ezzell, R.M., Kedinger, M., Erlanger, M., Xu, Z.X., Pringault, E., Leon-Robine, S., Louvard, D., Walker, W.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  9. Overexpression of human cyclin D1 reduces the transforming growth factor beta (TGF-beta) type II receptor and growth inhibition by TGF-beta 1 in an immortalized human esophageal epithelial cell line. Okamoto, A., Jiang, W., Kim, S.J., Spillare, E.A., Stoner, G.D., Weinstein, I.B., Harris, C.C. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  10. Mouse transgenes in human cells detect specific base substitutions. Schaff, D.A., Jarrett, R.A., Dlouhy, S.R., Ponniah, S., Stockelman, M., Stambrook, P.J., Tischfield, J.A. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  11. Cloning of the E. coli O-acetylserine sulfhydrylase gene: ability of the clone to produce a mutagenic product from azide and O-acetylserine. Owais, W.M., Gharaibeh, R. Mutat. Res. (1990) [Pubmed]
  12. A suramin derivative induces enterocyte-like differentiation of human colon cancer cells without lysosomal storage disorder. Baghdiguian, S., Nickel, P., Marvaldi, J., Fantini, J. Anticancer Drugs (1990) [Pubmed]
  13. Differentiated neuroblastoma cells are more susceptible to aluminium toxicity than developing cells. Roll, M., Banin, E., Meiri, H. Arch. Toxicol. (1989) [Pubmed]
  14. Acute lymphoblastic leukemia supervening in a case of chronic lymphocytic leukemia after continuous 3-year treatment with chlorambucil. Eridani, S., Parry, H., Glass, U., Greaves, M. Cancer (1984) [Pubmed]
  15. Regulation of cell division in a human glioma cell clone by arachidonic acid and alpha-tocopherolquinone. Liepkalns, V.A., Icard-Liepkalns, C., Cornwell, D.G. Cancer Lett. (1982) [Pubmed]
  16. CD2 rescues T cells from T-cell receptor/CD3 apoptosis: a role for the Fas/Fas-L system. Ayroldi, E., Migliorati, G., Cannarile, L., Moraca, R., Delfino, D.V., Riccardi, C. Blood (1997) [Pubmed]
  17. CD40-activated B-cell chronic lymphocytic leukemia cells for tumor immunotherapy: stimulation of allogeneic versus autologous T cells generates different types of effector cells. Buhmann, R., Nolte, A., Westhaus, D., Emmerich, B., Hallek, M. Blood (1999) [Pubmed]
  18. Human cutaneous fatty acid-binding protein induces metastasis by up-regulating the expression of vascular endothelial growth factor gene in rat Rama 37 model cells. Jing, C., Beesley, C., Foster, C.S., Chen, H., Rudland, P.S., West, D.C., Fujii, H., Smith, P.H., Ke, Y. Cancer Res. (2001) [Pubmed]
  19. Regulation of anchorage-independent growth by thyroid hormone in type 5 adenovirus-transformed rat embryo cells. Babiss, L.E., Guernsey, D.L., Fisher, P.B. Cancer Res. (1985) [Pubmed]
  20. Transfer and co-amplification of a gene encoding a 96-kDa immune IFN-inducible human melanoma-associated antigen. Preferential expression by mouse melanoma host cells. Graf, L.H., Rosenberg, C.D., Mancino, V., Ferrone, S. J. Immunol. (1988) [Pubmed]
  21. IL-3 and stromal cell-derived factor synergistically stimulate the growth of pre-B cell lines cloned from long-term lymphoid bone marrow cultures. Rennick, D., Jackson, J., Moulds, C., Lee, F., Yang, G. J. Immunol. (1989) [Pubmed]
  22. Expression of major histocompatibility complex class II and CD80 by gingival epithelial cells induces activation of CD4+ T cells in response to bacterial challenge. Matsuyama, T., Kawai, T., Izumi, Y., Taubman, M.A. Infect. Immun. (2005) [Pubmed]
  23. Interleukin-6 production by Schwann cells and induction in sciatic nerve injury. Bolin, L.M., Verity, A.N., Silver, J.E., Shooter, E.M., Abrams, J.S. J. Neurochem. (1995) [Pubmed]
  24. Phenotype and function of monocyte derived dendritic cells in chronic hepatitis B virus infection. Tavakoli, S., Schwerin, W., Rohwer, A., Hoffmann, S., Weyer, S., Weth, R., Meisel, H., Diepolder, H., Geissler, M., Galle, P.R., Löhr, H.F., Böcher, W.O. J. Gen. Virol. (2004) [Pubmed]
  25. Alpha isoform of smooth muscle actin is expressed in astrocytes in vitro and in vivo. Lecain, E., Alliot, F., Laine, M.C., Calas, B., Pessac, B. J. Neurosci. Res. (1991) [Pubmed]
  26. Effects of retinoic acid on morphological features and biological markers of a neoplastic human salivary intercalated duct cell line in culture. Azuma, M., Kawamata, H., Kasai, Y., Nagamine, S., Yoshida, H., Yanagawa, T., Sato, M. Cancer Res. (1988) [Pubmed]
  27. 5-Azacytidine induction of stable myoepithelial and acinar cells from a human salivary intercalated duct cell clone. Sato, M., Azuma, M., Hayashi, Y., Yoshida, H., Yanagawa, T., Yura, Y. Cancer Res. (1987) [Pubmed]
  28. In vitro fusion of endosomes following receptor-mediated endocytosis. Diaz, R., Mayorga, L., Stahl, P. J. Biol. Chem. (1988) [Pubmed]
  29. Transcriptional regulation of the interleukin 2 gene by glucocorticoid hormones. Role of steroid receptor and antigen-responsive 5'-flanking sequences. Vacca, A., Martinotti, S., Screpanti, I., Maroder, M., Felli, M.P., Farina, A.R., Gismondi, A., Santoni, A., Frati, L., Gulino, A. J. Biol. Chem. (1990) [Pubmed]
  30. Isolation and characterization of Chinese hamster ovary cell mutants deficient in acyl-coenzyme A:cholesterol acyltransferase activity. Cadigan, K.M., Heider, J.G., Chang, T.Y. J. Biol. Chem. (1988) [Pubmed]
  31. The 2',5'-oligoadenylate synthetase 1b is a potent inhibitor of West Nile virus replication inside infected cells. Kajaste-Rudnitski, A., Mashimo, T., Frenkiel, M.P., Guénet, J.L., Lucas, M., Desprès, P. J. Biol. Chem. (2006) [Pubmed]
  32. T cell activation signals up-regulate p38 mitogen-activated protein kinase activity and induce TNF-alpha production in a manner distinct from LPS activation of monocytes. Schafer, P.H., Wang, L., Wadsworth, S.A., Davis, J.E., Siekierka, J.J. J. Immunol. (1999) [Pubmed]
  33. Leukemia inhibitory factor regulates prolactin secretion in prolactinoma and lactotroph cells. Ben-Shlomo, A., Miklovsky, I., Ren, S.G., Yong, W.H., Heaney, A.P., Culler, M.D., Melmed, S. J. Clin. Endocrinol. Metab. (2003) [Pubmed]
  34. Effect of cyclosporine on interleukin 2 receptor expression in a human alloreactive T cell clone. Chabannes, D., Le Mauff, B., Hallet, M.M., Yacques, Y., Soulillou, J.P. Transplantation (1988) [Pubmed]
  35. Unresponsiveness of intrahepatic lymphocytes to bacterial superantigen: rapid development of suppressive Mac-1(high) cells in the mouse liver. Terabe, M., Shimizu, M., Mabuchi, A., Matui, S., Morikawa, H., Kaneda, K., Kakiuchi, T., Yokomuro, K. Hepatology (2000) [Pubmed]
  36. Analysis and significance of anti-latent membrane protein-1 antibodies in the sera of patients with EBV-associated diseases. Xu, J., Ahmad, A., D'Addario, M., Knafo, L., Jones, J.F., Prasad, U., Dolcetti, R., Vaccher, E., Menezes, J. J. Immunol. (2000) [Pubmed]
  37. Molecular pathology in basal cell cancer with p53 as a genetic marker. Pontén, F., Berg, C., Ahmadian, A., Ren, Z.P., Nistér, M., Lundeberg, J., Uhlén, M., Pontén, J. Oncogene (1997) [Pubmed]
  38. Transfected rat islet tumour cells express mouse major histocompatibility complex class I antigens functionally. Applicable as "pseudo-syngeneic" targets in the multiple low-dose streptozotocin diabetes model. Serup, P., Schøller, J. Diabetologia (1989) [Pubmed]
  39. Intracellular distribution of the envelope glycoprotein of human immunodeficiency virus and its role in the production of cytopathic effect in CD4+ and CD4- human cell lines. Koga, Y., Sasaki, M., Nakamura, K., Kimura, G., Nomoto, K. J. Virol. (1990) [Pubmed]
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