The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Mttp  -  microsomal triglyceride transfer protein

Rattus norvegicus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Mttp


High impact information on Mttp


Biological context of Mttp


Anatomical context of Mttp


Associations of Mttp with chemical compounds

  • Since apoB18 does not assemble triglyceride-rich lipoproteins, these studies suggest that apoB may interact with MTP before its lipidation [10].
  • Binding of all the polypeptides to MTP was enhanced in the presence of taurocholate [10].
  • Native VLDL bound poorly to MTP, but its preincubation with Tween-20 resulted in significantly increased binding to MTP [10].
  • Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats [11].
  • Inhibition of MTP activity abolished the oleate-induced utilization of prelabeled TG (by 80%) and hB48 (by 70%) for hB48-VLDL secretion but decreased utilization of pre-existing TG (by <25%) and B100 (by 45%) for rB100-VLDL secretion to a lesser extent [12].

Physical interactions of Mttp


Regulatory relationships of Mttp


Other interactions of Mttp


Analytical, diagnostic and therapeutic context of Mttp

  • Equal levels of MTP were also apparent in the livers of all groups of animals, as measured by immunoblotting with an anti-MTP antiserum [14].
  • The present study was designed to investigate the relationship between MTP expression and chylomicron assembly in an insulin resistant non-diabetic animal model [15].
  • Hepatic microsomal triglyceride transfer protein activity scaled to liver weight and metabolic body size was 2.69, 3.36, 4.58, 5.83, 7.49, and 22.3 nmole triolein transferred in the liver/min/kg body weight0.75 for the rabbit, guinea pig, rat, hen, cow, and sow, respectively [16].


  1. Microsomal triglyceride transfer protein is essential for hepatic secretion of apoB-100 and apoB-48 but not triglyceride. Hui, T.Y., Olivier, L.M., Kang, S., Davis, R.A. J. Lipid Res. (2002) [Pubmed]
  2. Decreased microsomal triglyceride transfer protein activity contributes to initiation of alcoholic liver steatosis in rats. Sugimoto, T., Yamashita, S., Ishigami, M., Sakai, N., Hirano, K., Tahara, M., Matsumoto, K., Nakamura, T., Matsuzawa, Y. J. Hepatol. (2002) [Pubmed]
  3. HIV protease inhibitors protect apolipoprotein B from degradation by the proteasome: a potential mechanism for protease inhibitor-induced hyperlipidemia. Liang, J.S., Distler, O., Cooper, D.A., Jamil, H., Deckelbaum, R.J., Ginsberg, H.N., Sturley, S.L. Nat. Med. (2001) [Pubmed]
  4. Secretion of apolipoprotein B-containing lipoproteins from HeLa cells is dependent on expression of the microsomal triglyceride transfer protein and is regulated by lipid availability. Gordon, D.A., Jamil, H., Sharp, D., Mullaney, D., Yao, Z., Gregg, R.E., Wetterau, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  5. Enhanced expression of hepatic acyl-coenzyme A synthetase and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation. Kuriyama, H., Yamashita, S., Shimomura, I., Funahashi, T., Ishigami, M., Aragane, K., Miyaoka, K., Nakamura, T., Takemura, K., Man, Z., Toide, K., Nakayama, N., Fukuda, Y., Lin, M.C., Wetterau, J.R., Matsuzawa, Y. Hepatology (1998) [Pubmed]
  6. Ethanol down-regulates the transcription of microsomal triglyceride transfer protein gene. Lin, M.C., Li, J.J., Wang, E.J., Princler, G.L., Kauffman, F.C., Kung, H.F. FASEB J. (1997) [Pubmed]
  7. The activity of microsomal triglyceride transfer protein is essential for accumulation of triglyceride within microsomes in McA-RH7777 cells. A unified model for the assembly of very low density lipoproteins. Wang, Y., Tran, K., Yao, Z. J. Biol. Chem. (1999) [Pubmed]
  8. Garlic inhibits microsomal triglyceride transfer protein gene expression in human liver and intestinal cell lines and in rat intestine. Lin, M.C., Wang, E.J., Lee, C., Chin, K.T., Liu, D., Chiu, J.F., Kung, H.F. J. Nutr. (2002) [Pubmed]
  9. Identification of microsomal triglyceride transfer protein in intestinal brush-border membrane. Slight, I., Bendayan, M., Malo, C., Delvin, E., Lambert, M., Levy, E. Exp. Cell Res. (2004) [Pubmed]
  10. Apolipoprotein B binding to microsomal triglyceride transfer protein decreases with increases in length and lipidation: implications in lipoprotein biosynthesis. Hussain, M.M., Bakillah, A., Jamil, H. Biochemistry (1997) [Pubmed]
  11. Dietary oxidized cholesterol decreases expression of hepatic microsomal triglyceride transfer protein in rats. Ringseis, R., Eder, K. J. Nutr. Biochem. (2004) [Pubmed]
  12. Normal activity of microsomal triglyceride transfer protein is required for the oleate-induced secretion of very low density lipoproteins containing apolipoprotein B from McA-RH7777 cells. Wang, Y., McLeod, R.S., Yao, Z. J. Biol. Chem. (1997) [Pubmed]
  13. Inhibition of the microsomal triglyceride transfer protein blocks the first step of apolipoprotein B lipoprotein assembly but not the addition of bulk core lipids in the second step. Gordon, D.A., Jamil, H., Gregg, R.E., Olofsson, S.O., Borén, J. J. Biol. Chem. (1996) [Pubmed]
  14. Microsomal triglyceride transfer protein activity remains unchanged in rat livers under conditions of altered very-low-density lipoprotein secretion. Brett, D.J., Pease, R.J., Scott, J., Gibbons, G.F. Biochem. J. (1995) [Pubmed]
  15. Microsomal triglyceride transfer protein: does insulin resistance play a role in the regulation of chylomicron assembly? Phillips, C., Owens, D., Collins, P., Tomkin, G.H. Atherosclerosis (2002) [Pubmed]
  16. Differences in activity of hepatic microsomal triglyceride transfer protein among species. Bremmer, D.R., Bertics, S.J., Grummer, R.R. Comp. Biochem. Physiol., Part A Mol. Integr. Physiol. (1999) [Pubmed]
WikiGenes - Universities