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Gene Review

MTTP  -  microsomal triglyceride transfer protein

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Disease relevance of MTP

  • Previous studies showing that the proximal cause of abetalipoproteinemia is an absence of MTP indicate that MTP function is required for the assembly of the apolipoprotein B (apoB) containing plasma lipoproteins, i.e., very low density lipoproteins and chylomicrons [1].
  • However, the lack of correlation between MTP activity, mass, or mRNA with either liver TG or plasma NEFA on d 2 postpartum suggests that MTP probably does not play a role in the etiology of fatty liver that occurs in dairy cows at calving [2].

High impact information on MTP

  • The similarity of the IC50 for inhibition of bovine MTP-mediated TG transfer (0.6 microM) to the Kd for binding of BMS-200150 to bovine MTP (1.3 microM) strongly supports that the inhibition of TG transfer is the result of a direct effect of the compound on MTP [1].
  • The microsomal triglyceride (TG) transfer protein (MTP) is a heterodimeric lipid transfer protein that catalyzes the transport of triglyceride, cholesteryl ester, and phosphatidylcholine between membranes [1].
  • LDL bound to LPL with high affinity (K(d) values of 10(-12) m) similar to that observed for the binding of LDL to its receptors and 1D1, a monoclonal antibody to LDL, and was greater than its affinity for microsomal triglyceride transfer protein [3].
  • Addition of one acyl chain from diglyceride to triglyceride, lysophosphatidylcholine to phosphatidylcholine, or cholesterol to cholesteryl ester increased the rate of MTP-mediated transport 10-fold [4].
  • When the triolein content of the vesicles was increased up to 4 mol %, neutral lipid binding to MTP increased proportionately, while phosphatidylcholine binding appeared to remain constant around two molecules per MTP [5].

Chemical compound and disease context of MTP


Biological context of MTP


Anatomical context of MTP


Associations of MTP with chemical compounds


Other interactions of MTP


Analytical, diagnostic and therapeutic context of MTP


  1. An inhibitor of the microsomal triglyceride transfer protein inhibits apoB secretion from HepG2 cells. Jamil, H., Gordon, D.A., Eustice, D.C., Brooks, C.M., Dickson, J.K., Chen, Y., Ricci, B., Chu, C.H., Harrity, T.W., Ciosek, C.P., Biller, S.A., Gregg, R.E., Wetterau, J.R. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  2. Changes in hepatic microsomal triglyceride transfer protein and triglyceride in periparturient dairy cattle. Bremmer, D.R., Bertics, S.J., Besong, S.A., Grummer, R.R. J. Dairy Sci. (2000) [Pubmed]
  3. High affinity binding between lipoprotein lipase and lipoproteins involves multiple ionic and hydrophobic interactions, does not require enzyme activity, and is modulated by glycosaminoglycans. Hussain, M.M., Obunike, J.C., Shaheen, A., Hussain, M.J., Shelness, G.S., Goldberg, I.J. J. Biol. Chem. (2000) [Pubmed]
  4. Microsomal triglyceride transfer protein. Specificity of lipid binding and transport. Jamil, H., Dickson, J.K., Chu, C.H., Lago, M.W., Rinehart, J.K., Biller, S.A., Gregg, R.E., Wetterau, J.R. J. Biol. Chem. (1995) [Pubmed]
  5. Identification of two classes of lipid molecule binding sites on the microsomal triglyceride transfer protein. Atzel, A., Wetterau, J.R. Biochemistry (1994) [Pubmed]
  6. Abundance of mRNA of apolipoprotein b100, apolipoprotein e, and microsomal triglyceride transfer protein in liver from periparturient dairy cows. Bernabucci, U., Ronchi, B., Basiricò, L., Pirazzi, D., Rueca, F., Lacetera, N., Nardone, A. J. Dairy Sci. (2004) [Pubmed]
  7. Mechanism of microsomal triglyceride transfer protein catalyzed lipid transport. Atzel, A., Wetterau, J.R. Biochemistry (1993) [Pubmed]
  8. Dietary trans octadecenoic acids upregulate the liver gene encoding peroxisome proliferator-activated receptor-alpha in transition dairy cows. Selberg, K.T., Staples, C.R., Luchini, N.D., Badinga, L. J. Dairy Res. (2005) [Pubmed]
  9. Inhibition of tubulin assembly and covalent binding to microtubular protein by valproic acid glucuronide in vitro. Cannell, G.R., Bailey, M.J., Dickinson, R.G. Life Sci. (2002) [Pubmed]
  10. Small intestine and liver microsomal triacylglycerol transfer protein in the bovine and rat: effects of dietary coconut oil. Graulet, B., Gruffat, D., Durand, D., Bauchart, D. J. Dairy Sci. (2004) [Pubmed]
  11. A simple, rapid, and sensitive fluorescence assay for microsomal triglyceride transfer protein. Athar, H., Iqbal, J., Jiang, X.C., Hussain, M.M. J. Lipid Res. (2004) [Pubmed]
  12. Structural properties of the microsomal triglyceride-transfer protein complex. Wetterau, J.R., Aggerbeck, L.P., Laplaud, P.M., McLean, L.R. Biochemistry (1991) [Pubmed]
  13. Etiology of fatty liver in dairy cattle: effects of nutritional and hormonal status on hepatic microsomal triglyceride transfer protein. Bremmer, D.R., Trower, S.L., Bertics, S.J., Besong, S.A., Bernabucci, U., Grummer, R.R. J. Dairy Sci. (2000) [Pubmed]
  14. Short communication: Hepatic gene expression for gluconeogenic enzymes in lactating dairy cows treated with bovine somatotropin. Pershing, R.A., Moore, S.D., Dinges, A.C., Thatcher, W.W., Badinga, L. J. Dairy Sci. (2002) [Pubmed]
  15. Zomepirac acyl glucuronide covalently modifies tubulin in vitro and in vivo and inhibits its assembly in an in vitro system. Bailey, M.J., Worrall, S., de Jersey, J., Dickinson, R.G. Chem. Biol. Interact. (1998) [Pubmed]
  16. Crystallization of microsomal triglyceride transfer protein from bovine liver. Ohringer, S.L., Jamil, H., Chu, C.H., Tabernero, L., Einspahr, H.M., Wetterau, J.R., Sack, J.S. Acta Crystallogr. D Biol. Crystallogr. (1996) [Pubmed]
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