Gene Review:
WDR1 - WD repeat domain 1
Gallus gallus
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High impact information on WDR1
- We examined WDR1 expression in the developing, mature, and noise-damaged chick cochlea by in situ hybridization and immunocytochemistry [1].
- These results indicate that one of the immediate responses of the supporting cell after noise exposure is to induce WDR1 gene expression and thus to increase the rate of actin filament turnover [1].
- In the developing inner ear, WDR1 mRNA was detected in homogene cells and cuboidal cells by embryonic day 7, in the undifferentiated sensory epithelium by day 9, and in hair cells at embryonic day 16 [1].
Anatomical context of WDR1
- In the mature cochlea, WDR1 mRNA was detected in hair cells, homogene cells, and cuboidal cells, all of which contain high levels of F-actin [1].
References
- WDR1 colocalizes with ADF and actin in the normal and noise-damaged chick cochlea. Oh, S.H., Adler, H.J., Raphael, Y., Lomax, M.I. J. Comp. Neurol. (2002) [Pubmed]
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