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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

AIP1  -  Aip1p

Saccharomyces cerevisiae S288c

Synonyms: Actin-interacting protein 1, YM9582.17C, YMR092C
 
 
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High impact information on AIP1

  • DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility [1].
  • Through systematic mutagenesis of Aip1 surfaces, we identify two well-separated F-actin-binding sites, one of which contributes to actin filament binding and disassembly specifically in the presence of cofilin [2].
  • We provide the first demonstration that Aip1 promotes actin turnover in living cells [2].
  • Bro1-domain proteins such as yeast Bro1 and mammalian AIP1/Alix are well-established participants in endosome metabolism [3].
  • These two patches of conserved residues suggest a potential binding site for F-actin on Aip1p and that the orientation of the beta-propellers with respect to one another plays a role in binding an actin-cofilin complex [4].
 

Biological context of AIP1

 

Anatomical context of AIP1

 

Other interactions of AIP1

  • Thick and long fibres stained with anti-cofilin antibody were detected in Deltascf1/aip1 cells, but not in SCF1/AIP1 cells [5].
  • Consistent with this model, deletion of AIP1 rescues the temperature-sensitive growth and loss of actin cable defects of tpm1Delta mutants [2].
  • Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites [9].
  • Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage [10].

References

  1. DAip1, a Dictyostelium homologue of the yeast actin-interacting protein 1, is involved in endocytosis, cytokinesis, and motility. Konzok, A., Weber, I., Simmeth, E., Hacker, U., Maniak, M., Müller-Taubenberger, A. J. Cell Biol. (1999) [Pubmed]
  2. Aip1 and cofilin promote rapid turnover of yeast actin patches and cables: a coordinated mechanism for severing and capping filaments. Okada, K., Ravi, H., Smith, E.M., Goode, B.L. Mol. Biol. Cell (2006) [Pubmed]
  3. Control of Bro1-domain protein Rim20 localization by external pH, ESCRT machinery, and the Saccharomyces cerevisiae Rim101 pathway. Boysen, J.H., Mitchell, A.P. Mol. Biol. Cell (2006) [Pubmed]
  4. The structure of Aip1p, a WD repeat protein that regulates Cofilin-mediated actin depolymerization. Voegtli, W.C., Madrona, A.Y., Wilson, D.K. J. Biol. Chem. (2003) [Pubmed]
  5. Cooperation of two actin-binding proteins, cofilin and Aip1, in Saccharomyces cerevisiae. Iida, K., Yahara, I. Genes Cells (1999) [Pubmed]
  6. Dictyostelium discoideum requires an Alix/AIP1 homolog, DdAlix, for morphogenesis in alkaline environments. Ohkouchi, S., Saito, H., Aruga, F., Maeda, T., Shibata, H., Maki, M. FEBS Lett. (2005) [Pubmed]
  7. SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins. Borinstein, S.C., Hyatt, M.A., Sykes, V.W., Straub, R.E., Lipkowitz, S., Boulter, J., Bogler, O. Cell. Signal. (2000) [Pubmed]
  8. Fission yeast Aip3p (spAip3p) is required for an alternative actin-directed polarity program. Jin, H., Amberg, D.C. Mol. Biol. Cell (2001) [Pubmed]
  9. Aip3p/Bud6p, a yeast actin-interacting protein that is involved in morphogenesis and the selection of bipolar budding sites. Amberg, D.C., Zahner, J.E., Mulholland, J.W., Pringle, J.R., Botstein, D. Mol. Biol. Cell (1997) [Pubmed]
  10. Yeast PalA/AIP1/Alix homolog Rim20p associates with a PEST-like region and is required for its proteolytic cleavage. Xu, W., Mitchell, A.P. J. Bacteriol. (2001) [Pubmed]
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