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Gene Review

JUN  -  jun proto-oncogene

Gallus gallus

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Disease relevance of JUN

  • The JUN oncoprotein, which causes sarcomas in chickens, shows significant homology to the DNA-binding domain of GCN4, a yeast protein that stimulates transcription of the amino acid biosynthetic genes [1].

High impact information on JUN


  1. The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Struhl, K. Nature (1988) [Pubmed]
  2. Differential expression of fos and jun family members in the developing chicken gastrointestinal tract. Matsumoto, K., Saitoh, K., Koike, C., Narita, T., Yasugi, S., Iba, H. Oncogene (1998) [Pubmed]
  3. c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. Zahradnícková, E., Soucek, K., Sevcíková, S., Smardová, J., Smarda, J. Cell. Mol. Life Sci. (2003) [Pubmed]
  4. Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells. Niehoff, L.B., Uckun, F.M. Radiat. Res. (2000) [Pubmed]
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