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Gene Review:

JUN - jun proto-oncogene

Gallus gallus

Struhl, K., Matsumoto, K. et al., Zahradnícková, E. et al., Niehoff, L.B. et al.

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Disease relevance of JUN

The JUN oncoprotein, which causes sarcomas in chickens, shows significant homology to the DNA-binding domain of GCN4, a yeast protein that stimulates transcription of the amino acid biosynthetic genes [1].

High impact information on JUN

The GCN4 and JUN proteins bind the same DNA sequences, consensus ATGA(C/G)TCAT, even though the DNA-binding domains are only 45% identical in amino acid sequence [1].
We have analysed the expression patterns of all the known fos/jun family genes, which encode the components of the transcription factor AP-1, in the chicken embryonic digestive tract that develops into the esophagus, proventriculus, gizzard, small intestine, ceca and large intestine [2].
c-Fos and v-Fos belong to a group of proteins forming the transcription factor AP-1 that is important for regulation of proliferation, differentiation and programmed cell death in multiple cell types [3].
Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells [4].

References

The JUN oncoprotein, a vertebrate transcription factor, activates transcription in yeast. Struhl, K. Nature (1988) [Pubmed]
Differential expression of fos and jun family members in the developing chicken gastrointestinal tract. Matsumoto, K., Saitoh, K., Koike, C., Narita, T., Yasugi, S., Iba, H. Oncogene (1998) [Pubmed]
c-Fos but not v-Fos protein induces programmed cell death of v-myb-transformed monoblasts. Zahradnícková, E., Soucek, K., Sevcíková, S., Smardová, J., Smarda, J. Cell. Mol. Life Sci. (2003) [Pubmed]
Role of PRKCM (PKCmu) in radiation-induced increase of JUN proto-oncogene mRNA levels in B-lineage lymphoid cells. Niehoff, L.B., Uckun, F.M. Radiat. Res. (2000) [Pubmed]

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AgaP_AGAP006386	Anopheles gambiae str. PEST
JUN	Bos taurus
JUN	Canis lupus familiaris
jun	Danio rerio
JUN	Homo sapiens
JUN	Macaca mulatta
Jun	Mus musculus
JUN	Pan troglodytes
Jun	Rattus norvegicus
jun	Xenopus (Silurana) tropicalis

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