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Gene Review

VAChT  -  CG32848 gene product from transcript...

Drosophila melanogaster

Synonyms: CG12345, CG32848, CT41182, Dmel\CG32848, VACHT, ...
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High impact information on VAChT

  • The requirement for acetylcholine signaling exists before photoreceptor neurons form synaptic connections and does not require the function of vesicular acetylcholine transporter protein [1].
  • RNase protection analysis indicates that all Drosophila VAChT specific transcripts contain the shared first exon and suggests common transcriptional control for ChAT and VAChT [2].
  • These features of the VAChT 5'-UTR region suggest that a ribosome scanning model may not be used for VAChT translation initiation [2].
  • We identify two mRNA splice variants (DVMAT-A and B) that differ at their C-terminus, the domain responsible for endocytosis of mammalian VMAT and VAChT [3].

Anatomical context of VAChT


Other interactions of VAChT

  • Both genes share a common first exon and the remainder of the VAChT gene contains a single coding exon residing entirely within the first intron of ChAT [2].

Analytical, diagnostic and therapeutic context of VAChT

  • Complementation tests with a Cha mutant allele and rescue experiments using a transgenic Vacht minigene have revealed that two of these three mutations are nonconditional lethal alleles of Vacht (Vacht(1) and Vacht(2) ) [5].


  1. Nonvesicular release of acetylcholine is required for axon targeting in the Drosophila visual system. Yang, H., Kunes, S. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  2. Structure and organization of the Drosophila cholinergic locus. Kitamoto, T., Wang, W., Salvaterra, P.M. J. Biol. Chem. (1998) [Pubmed]
  3. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. Greer, C.L., Grygoruk, A., Patton, D.E., Ley, B., Romero-Calderon, R., Chang, H.Y., Houshyar, R., Bainton, R.J., Diantonio, A., Krantz, D.E. J. Neurobiol. (2005) [Pubmed]
  4. Synaptic organization of the mushroom body calyx in Drosophila melanogaster. Yasuyama, K., Meinertzhagen, I.A., Schürmann, F.W. J. Comp. Neurol. (2002) [Pubmed]
  5. Isolation and characterization of mutants for the vesicular acetylcholine transporter gene in Drosophila melanogaster. Kitamoto, T., Xie, X., Wu, C.F., Salvaterra, P.M. J. Neurobiol. (2000) [Pubmed]
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