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Gene Review

Slc18a3  -  solute carrier family 18 (vesicular...

Mus musculus

Synonyms: Solute carrier family 18 member 3, VAChT, VAT, Vacht, Vesicular acetylcholine transporter
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High impact information on Slc18a3


Biological context of Slc18a3

  • Transfection assays showed that this region strongly represses the activity of the native VAChT promoters in non-neuronal cells, but has no major effect in neuronal cells whether or not they express the endogenous ChAT and VAChT genes [4].
  • Moreover, we found that clathrin-mediated endocytosis of VAChT is required for targeting to microvesicles in SN56 and PC12 cells [5].

Anatomical context of Slc18a3


Associations of Slc18a3 with chemical compounds


Other interactions of Slc18a3

  • Already at embryonic day 16 (E16), ChAT and VAChT-positive cells are affected by the c-ret mutation [13].
  • Periosteal innervation of mice lacking CNTF, LIF, or both, like that of wild-type mice, is immunoreactive for the vesicular acetylcholine transporter, a recently identified cholinergic marker, and VIP [14].
  • The distribution of calcitonin gene-related peptide (CGRP)-, nNOS-, VAChT- and VIP-IR nerve structures was unchanged [15].
  • Synaptophysin-, VAChT- and NOS-immunoreactive nerve terminals were present within the external muscle prior to the formation of receptor clusters, and their appearance did not follow any apparent rostrocaudal sequence [16].
  • VAChT-positive preganglionic neurons were found to terminate on ZnT3 neuronal somata [17].

Analytical, diagnostic and therapeutic context of Slc18a3


  1. Mice deficient for the vesicular acetylcholine transporter are myasthenic and have deficits in object and social recognition. Prado, V.F., Martins-Silva, C., de Castro, B.M., Lima, R.F., Barros, D.M., Amaral, E., Ramsey, A.J., Sotnikova, T.D., Ramirez, M.R., Kim, H.G., Rossato, J.I., Koenen, J., Quan, H., Cota, V.R., Moraes, M.F., Gomez, M.V., Guatimosim, C., Wetsel, W.C., Kushmerick, C., Pereira, G.S., Gainetdinov, R.R., Izquierdo, I., Caron, M.G., Prado, M.A. Neuron (2006) [Pubmed]
  2. Cholinergic neuronal defect without cell loss in Huntington's disease. Smith, R., Chung, H., Rundquist, S., Maat-Schieman, M.L., Colgan, L., Englund, E., Liu, Y.J., Roos, R.A., Faull, R.L., Brundin, P., Li, J.Y. Hum. Mol. Genet. (2006) [Pubmed]
  3. Interstitial cells of Cajal mediate cholinergic neurotransmission from enteric motor neurons. Ward, S.M., Beckett, E.A., Wang, X., Baker, F., Khoyi, M., Sanders, K.M. J. Neurosci. (2000) [Pubmed]
  4. Is RE1/NRSE a common cis-regulatory sequence for ChAT and VAChT genes? De Gois, S., Houhou, L., Oda, Y., Corbex, M., Pajak, F., Thévenot, E., Vodjdani, G., Mallet, J., Berrard, S. J. Biol. Chem. (2000) [Pubmed]
  5. Structural requirements for steady-state localization of the vesicular acetylcholine transporter. Ferreira, L.T., Santos, M.S., Kolmakova, N.G., Koenen, J., Barbosa, J., Gomez, M.V., Guatimosim, C., Zhang, X., Parsons, S.M., Prado, V.F., Prado, M.A. J. Neurochem. (2005) [Pubmed]
  6. Dopaminergic innervation of the mouse inner ear: evidence for a separate cytochemical group of cochlear efferent fibers. Darrow, K.N., Simons, E.J., Dodds, L., Liberman, M.C. J. Comp. Neurol. (2006) [Pubmed]
  7. Cholinergic differentiation occurs early in mouse sympathetic neurons and requires Phox2b. Huber, K., Ernsberger, U. Gene Expr. (2006) [Pubmed]
  8. Molecular characterization of the mouse vesicular acetylcholine transporter gene. Naciff, J.M., Misawa, H., Dedman, J.R. Neuroreport (1997) [Pubmed]
  9. Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. Wong, T.P., Debeir, T., Duff, K., Cuello, A.C. J. Neurosci. (1999) [Pubmed]
  10. Molecular cloning and functional identification of mouse vesicular glutamate transporter 3 and its expression in subsets of novel excitatory neurons. Schäfer, M.K., Varoqui, H., Defamie, N., Weihe, E., Erickson, J.D. J. Biol. Chem. (2002) [Pubmed]
  11. Coordinated up-regulation of choline acetyltransferase and vesicular acetylcholine transporter gene expression by the retinoic acid receptor alpha, cAMP, and leukemia inhibitory factor/ciliary neurotrophic factor signaling pathways in a murine septal cell line. Berse, B., Blusztajn, J.K. J. Biol. Chem. (1995) [Pubmed]
  12. Modulation of cholinergic locus expression by glucocorticoids and retinoic acid is cell-type specific. Berse, B., Blusztajn, J.K. FEBS Lett. (1997) [Pubmed]
  13. c-ret regulates cholinergic properties in mouse sympathetic neurons: evidence from mutant mice. Burau, K., Stenull, I., Huber, K., Misawa, H., Berse, B., Unsicker, K., Ernsberger, U. Eur. J. Neurosci. (2004) [Pubmed]
  14. CNTF and LIF are not required for the target-directed acquisition of cholinergic and peptidergic properties by sympathetic neurons in vivo. Francis, N.J., Asmus, S.E., Landis, S.C. Dev. Biol. (1997) [Pubmed]
  15. Morphological and functional in vitro and in vivo characterization of the mouse corpus cavernosum. Mizusawa, H., Hedlund, P., Håkansson, A., Alm, P., Andersson, K.E. Br. J. Pharmacol. (2001) [Pubmed]
  16. Development of nicotinic receptor clusters and innervation accompanying the change in muscle phenotype in the mouse esophagus. Sang, Q., Young, H.M. J. Comp. Neurol. (1997) [Pubmed]
  17. Zinc transporter 3 and zinc ions in the rodent superior cervical ganglion neurons. Wang, Z.Y., Danscher, G., Dahlström, A., Li, J.Y. Neuroscience (2003) [Pubmed]
  18. Loss of nitrergic neurotransmission to mouse corpus cavernosum in the absence of neurturin is accompanied by increased response to acetylcholine. Nangle, M.R., Keast, J.R. Br. J. Pharmacol. (2006) [Pubmed]
  19. Vesicular acetylcholine transporter (VAChT) protein: a novel and unique marker for cholinergic neurons in the central and peripheral nervous systems. Arvidsson, U., Riedl, M., Elde, R., Meister, B. J. Comp. Neurol. (1997) [Pubmed]
  20. Location of interstitial cells and neurotransmitters in the mouse bladder. Lagou, M., De Vente, J., Kirkwood, T.B., Hedlund, P., Andersson, K.E., Gillespie, J.I., Drake, M.J. BJU Int. (2006) [Pubmed]
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