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Gene Review

Gdh  -  Glutamate dehydrogenase

Drosophila melanogaster

Synonyms: CG5320, DHE3, Dmel\CG5320, GDH, GLU-D, ...
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High impact information on Gdh

  • DNA-specific sequences from an enzyme-coding gene (glutamate dehydrogenase, gdh), a regulatory protein-coding gene (E74) and genes of the actin family were mapped by in situ hybridization on the polytene chromosomes of six species representative of the geographical distribution of the Drosophila montium subgroup of the melanogaster species group [1].
  • We present the results of an analysis of the spatial and temporal distribution of enzymatic activities thought to be important in the regulation of transmitter-glutamate pools (i.e., glutamate oxaloacetic transaminase, glutaminase, and glutamate dehydrogenase) [2].
  • We have obtained monoclonal antibodies to Drosophila acetylcholinesterase, glutamate dehydrogenase as well as other unknown macromolecules which may have some relevance in synaptic function [3].
  • Moreover, we detect the localization of the Gdh protein in specific areas of the muscles, a fact that is consistent both with an involvement in energy metabolism and the role of glutamate as the major neuromuscular transmitter in Drosophila [4].
  • We show the presence of Gdh mRNA in several tissues of the developing embryo, including the central nervous system, muscles and the alimentary tract [4].

Anatomical context of Gdh


  1. The glutamate dehydrogenase, E74 and putative actin gene loci in the Drosophila montium subgroup. Chromosomal homologies among the montium species and D. melanogaster. Drosopoulou, E., Tsiafouli, M., Mavragani-Tsipidou, P., Scouras, Z.G. Chromosoma (1997) [Pubmed]
  2. A genetic analysis of glutamatergic function in Drosophila. Chase, B.A., Kankel, D.R. J. Neurobiol. (1987) [Pubmed]
  3. Monoclonal antibodies to synaptic macromolecules of Drosophila melanogaster. Rane, N., Jithra, L., Pinto, L., Rodrigues, V., Krishnan, K.S. J. Neuroimmunol. (1987) [Pubmed]
  4. The glutamate dehydrogenase GENE of Drosophila melanogaster: molecular analysis and expression. Papadopoulou, D., Louis, C. J. Neurogenet. (2000) [Pubmed]
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