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Gene Review

Glud1  -  glutamate dehydrogenase 1

Mus musculus

Synonyms: AI118167, GDH 1, Gdh-X, Glud, Gludl, ...
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Disease relevance of Glud1


High impact information on Glud1


Chemical compound and disease context of Glud1


Biological context of Glud1


Anatomical context of Glud1


Associations of Glud1 with chemical compounds

  • Leucine and ADP are activators and GTP is an inhibitor of GDH [2].
  • Enzyme analyses of culture medium and cell homogenates have detected some enzymes characteristic of liver tissue such as gamma-glutamyl transferase, sorbital dehydrogenase, alkaline phosphatase, glutamate dehydrogenase, as well as aspartate and alanine transaminase [19].
  • For example, the enzyme 6-phosphogluconate dehydrogenase has a much higher average heterozygosity than glutamate dehydrogenase [20].
  • The activities of another cytosolic enzyme, lactate dehydrogenase, the mitochondrial enzymes glutamate dehydrogenase, succinate dehydrogenase, cytochrome c oxidase and the activity of the lysosomal enzymes acid phosphatase and beta-glucuronidase were, initially, not or only slightly affected [21].
  • When combined preparations of mitochondria and lysosomes are irradiated, inactivation of enzymes occurs in the following order: succinate dehydrogenase greater than glutamate dehydrogenase greater than acid phosphatase greater than beta-glucuronidase [22].
  • Isolated islets with either constitutive or acute adenovirus-mediated knock-out of GDH showed a 49 and 38% reduction in glucose-induced insulin release, respectively [23].

Other interactions of Glud1


Analytical, diagnostic and therapeutic context of Glud1


  1. Glucose regulation of glutaminolysis and its role in insulin secretion. Gao, Z.Y., Li, G., Najafi, H., Wolf, B.A., Matschinsky, F.M. Diabetes (1999) [Pubmed]
  2. Glutaminolysis and insulin secretion: from bedside to bench and back. Kelly, A., Li, C., Gao, Z., Stanley, C.A., Matschinsky, F.M. Diabetes (2002) [Pubmed]
  3. Antibodies to the glutamate dehydrogenase of Plasmodium falciparum. Ling, I.T., Cooksley, S., Bates, P.A., Hempelmann, E., Wilson, R.J. Parasitology (1986) [Pubmed]
  4. Glutamate dehydrogenase activity in subcellular fractions of mouse fibrosarcoma. Hillar, M., Lennox, B. Mol. Biol. Rep. (1979) [Pubmed]
  5. The progeny of a single progenitor cell can develop characteristics of either a tissue or an alveolar macrophage. Bar-Eli, M., Territo, M.C., Cline, M.J. Blood (1981) [Pubmed]
  6. Transport of anionic substrates and glutamate metabolism in mitochondria from ascites tumor cells. Eboli, M.L., Paradies, G., Papa, S. Cancer Res. (1976) [Pubmed]
  7. IFN-gamma promotes Fas ligand- and perforin-mediated liver cell destruction by cytotoxic CD8 T cells. Roth, E., Pircher, H. J. Immunol. (2004) [Pubmed]
  8. Demonstration of glutamate dehydrogenase isozymes in beef heart mitochondria. McDaniel, H., Bosing-Schneider, R., Jenkins, R., Rasched, I., Sund, H. J. Biol. Chem. (1986) [Pubmed]
  9. Effects of sodium nitroprusside on blood glucose concentration, B-cell morphology and islet glutamate dehydrogenase activity in mice. Boquist, L. APMIS (1989) [Pubmed]
  10. Enzyme activities of six different dehydrogenases in Ehrlich ascites cells measured by flow cytometry. Huang, C.J., Severin, E. Acta Histochem. (1993) [Pubmed]
  11. Chromosomal mapping of glutamate dehydrogenase gene sequences to mouse chromosomes 7 and 14. Tzimagiorgis, G., Adamson, M.C., Kozak, C.A., Moschonas, N.K. Genomics (1991) [Pubmed]
  12. Isolation of a human brain cDNA for glutamate dehydrogenase. Banner, C., Silverman, S., Thomas, J.W., Lampel, K.A., Vitkovic, L., Huie, D., Wenthold, R.J. J. Neurochem. (1987) [Pubmed]
  13. Regulation of insulin secretion by energy metabolism in pancreatic B-cell mitochondria. Studies with a non-metabolizable leucine analogue. Panten, U., Zielmann, S., Langer, J., Zünkler, B.J., Lenzen, S. Biochem. J. (1984) [Pubmed]
  14. Glutamate-modulated production of GABA in immortalized astrocytes transduced by a glutamic acid decarboxylase-expressing retrovirus. Sacchettoni, S.A., Benchaibi, M., Sindou, M., Belin, M.F., Jacquemont, B. Glia (1998) [Pubmed]
  15. Transamination of neutral amino acids and 2-keto acids in pancreatic B-cell mitochondria. Lenzen, S., Schmidt, W., Panten, U. J. Biol. Chem. (1985) [Pubmed]
  16. Glutamate dehydrogenase activity is markedly higher in a "Golgi-Bergmann"-like glial clone than in other astroglial cell lines. Cambier, D., Pessac, B. J. Neurochem. (1988) [Pubmed]
  17. Distinguishing features of leucine and alpha-ketoisocaproate sensing in pancreatic beta-cells. Gao, Z., Young, R.A., Li, G., Najafi, H., Buettger, C., Sukumvanich, S.S., Wong, R.K., Wolf, B.A., Matschinsky, F.M. Endocrinology (2003) [Pubmed]
  18. A Trypanosoma cruzi antigen signals CD11b+ cells to secrete cytokines that promote polyclonal B cell proliferation and differentiation into antibody-secreting cells. Montes, C.L., Acosta-Rodríguez, E.V., Mucci, J., Zuniga, E.I., Campetella, O., Gruppi, A. Eur. J. Immunol. (2006) [Pubmed]
  19. Culturing of human hepatocellular carcinoma. A simple and reproducible method. Laohathai, K., Bhamarapravati, N. Am. J. Pathol. (1985) [Pubmed]
  20. Average allozyme heterozygosity in vertebrates correlates with Ka/Ks measured in the human-mouse lineage. Skibinski, D.O., Ward, R.D. Mol. Biol. Evol. (2004) [Pubmed]
  21. Toxic effects of ozone on murine L929 fibroblasts. Enzyme inactivation and glutathione depletion. Van der Zee, J., Dubbelman, T.M., Raap, T.K., Van Steveninck, J. Biochem. J. (1987) [Pubmed]
  22. Phototoxicity of protoporphyrin as related to its subcellular localization in mice livers after short-term feeding with griseofulvin. Sandberg, S., Romslo, I. Biochem. J. (1981) [Pubmed]
  23. Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis. Carobbio, S., Frigerio, F., Rubi, B., Vetterli, L., Bloksgaard, M., Gjinovci, A., Pournourmohammadi, S., Herrera, P.L., Reith, W., Mandrup, S., Maechler, P. J. Biol. Chem. (2009) [Pubmed]
  24. FAD-linked glycerophosphate dehydrogenase deficiency in pancreatic islets of mice with hereditary diabetes. Sener, A., Herberg, L., Malaisse, W.J. FEBS Lett. (1993) [Pubmed]
  25. Neurotransmitter metabolizing enzymes and plasma butyrylcholinesterase in mice exposed to trichloroethylene. Kanje, M., Kjellstrand, P., Fex, K., Walldorf, A. Acta pharmacologica et toxicologica. (1981) [Pubmed]
  26. Effect of starvation on glutamine ammoniagenesis and gluconeogenesis in isolated mouse kidney tubules. Conjard, A., Brun, V., Martin, M., Baverel, G., Ferrier, B. Biochem. J. (2002) [Pubmed]
  27. Altered enzyme activities and citrulline synthesis in liver mitochondria from ornithine carbamoyltransferase-deficient sparse-furash mice. Cohen, N.S., Cheung, C.W., Raijman, L. Biochem. J. (1989) [Pubmed]
  28. Glutamate dehydrogenase covalently binds to a reactive metabolite of acetaminophen. Halmes, N.C., Hinson, J.A., Martin, B.M., Pumford, N.R. Chem. Res. Toxicol. (1996) [Pubmed]
  29. Glutamate dehydrogenase in cerebellar mutant mice: gene localization and enzyme activity in different tissues. Miret-Duvaux, O., Frederic, F., Simon, D., Guenet, J.L., Hanauer, A., Delhaye-Bouchaud, N., Mariani, J. J. Neurochem. (1990) [Pubmed]
  30. Molecular cloning, structure and expression analysis of a full-length mouse brain glutamate dehydrogenase cDNA. Tzimagiorgis, G., Moschonas, N.K. Biochim. Biophys. Acta (1991) [Pubmed]
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