The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

GLUD1  -  glutamate dehydrogenase 1

Gallus gallus

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of GLUD1


High impact information on GLUD1


Biological context of GLUD1

  • Liver and kidney function tests included serum SDH, GDH, GOT, total protein, potassium and other serum constituents in addition to total tissue lipids and hematology [6].
  • We determined the nucleotide sequence of chicken GDH cDNA and showed that the GDH transcript was widely expressed in the chicken organs [7].

Anatomical context of GLUD1


Associations of GLUD1 with chemical compounds


Other interactions of GLUD1


Analytical, diagnostic and therapeutic context of GLUD1

  • We examined the localization of TM and GDH by immunohistochemistry and revealed that they were distributed in the cytoplasm of the adult chicken liver [7].
  • Semi-nondenaturing 2D-PAGE revealed that partially purified GDH from the nuclear fraction was associated with TM, but not GDH from the mitochondrial fraction, suggesting preferential binding of TM to GDH [7].


  1. Effect on ochratoxin A on Lohmann-type chicks. Ayed, I.A., Dafalla, R., Yagi, A.I., Adam, S.E. Veterinary and human toxicology. (1991) [Pubmed]
  2. Metabolism and transport of L-glutamine and L-alanine by renal tubules of chickens. Craan, A.G., Vinay, P., Lemieux, G., Gougoux, A. Am. J. Physiol. (1983) [Pubmed]
  3. Submitochondrial localization and function of enzymes of glutamine metabolism in avian liver. Vorhaben, J.E., Campbell, J.W. J. Cell Biol. (1977) [Pubmed]
  4. Evaluation of the relationship between the intra- and extramitochondrial [ATP]/[ADP] ratios using phosphoenolpyruvate carboxykinase. Wilson, D.F., Erecińska, M., Schramm, V.L. J. Biol. Chem. (1983) [Pubmed]
  5. Nicotinamide adenine dinucleotide phosphate-specific glutamate dehydrogenase of Neurospora. Blumenthal, K.M., Moon, K., Smith, E.L. J. Biol. Chem. (1975) [Pubmed]
  6. Toxic effects of low levels of dietary Jatropha curcas seed on Brown Hisex chicks. el Badwi, S.M., Adam, S.E. Veterinary and human toxicology. (1992) [Pubmed]
  7. Biochemical and immunohistochemical studies on tropomyosin and glutamate dehydrogenase in the chicken liver. Akutsu, S., Miyazaki, J. Zool. Sci. (2002) [Pubmed]
  8. Differential modulation of glutamate metabolizing enzymes in mouse and chick cultured glial cells by insulin. Sena, A., Ferret-Sena, V., Sarliève, L.L., Tholey, G. J. Neurosci. Res. (1988) [Pubmed]
  9. Metabolic pathways in chick amnion muscle. A cytochemical study. Müller, E., Schneider, M., Rickenbacher, J. Acta anatomica. (1983) [Pubmed]
  10. Physiological studies on the effects of nutritional imbalance on the central nervous system. II. Effects of thiamine deficiency on oxidative enzymes in the brain of chicken, Gallus domesticus. Nalini, U.P., Nayeemunnisa, n.u.l.l. Experientia (1976) [Pubmed]
  11. Distribution of glutamate dehydrogenase and glutamine synthetase activity in the sheep and chicken digestive tract. Holovská, K., Lenártová, V., Havassy, I. Physiologia Bohemoslovaca. (1979) [Pubmed]
  12. Prominent glutamine oxidation activity in mitochondria of avian transplantable hepatoma induced by MC-29 virus. Matsuno, T., Satoh, T., Suzuki, H. J. Cell. Physiol. (1986) [Pubmed]
  13. The use of selected plasma enzyme activities for the diagnosis of fatty liver-hemorrhagic syndrome in laying hens. Diaz, G.J., Squires, E.J., Julian, R.J. Avian Dis. (1999) [Pubmed]
  14. Avian malaria: clinical and chemical pathology of Plasmodium gallinaceum in the domesticated fowl Gallus gallus. Williams, R.B. Avian Pathol. (2005) [Pubmed]
  15. Activity of certain liver enzymes in fast- and slow-growing lines of chickens. Proudman, J.A., Mellen, W.J., Hultin, H.O. Poult. Sci. (1975) [Pubmed]
  16. Amino-acid metabolism enzyme activities in the liver, intestine and yolk sac membrane of developing domestic fowl. Pons, A., García, F.J., Palou, A., Alemany, M. Arch. Int. Physiol. Biochim. (1986) [Pubmed]
  17. Variation in the response of plasma enzyme activities in avian species dosed with carbophenothion. Westlake, G.E., Bunyan, P.J., Stanley, P.I. Ecotoxicol. Environ. Saf. (1978) [Pubmed]
WikiGenes - Universities