The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

BM-40-SPARC  -  CG6378 gene product from transcript CG6378-RA

Drosophila melanogaster

Synonyms: BM-40 Sparc, BM-40/SPARC, BM40, CG6378, CT19876, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on BM-40-SPARC

  • Mutations in type IV collagen are associated with a dramatic decrease in dSPARC protein immunostaining in hemocytes [1].
  • Immunostaining with anti- DrosophilaSPARC antibodies indicates that dSPARC secreted by the hemocytes and fat body cells is concentrated in basal laminae surrounding internal organs [1].
  • The data suggest that the production and assembly of dSPARC in the basal lamina is dependent on type IV collagen, and raise the possibility that dSPARC and type IV collagen interactions are a prerequisite to the assembly and structural integrity of basal laminae in Drosophila [1].
  • During embryogenesis, dSPARC mRNA transcripts are restricted to mesoderm derivatives, hemocytes, and the fat body [1].
  • Genome analysis has revealed a single copy of the DrosophilaSPARC ( dSPARC) gene [1].
 

Biological context of BM-40-SPARC

  • During oogenesis, dSPARC transcripts are restricted to the somatic cells of the germarium and follicles [1].
 

Analytical, diagnostic and therapeutic context of BM-40-SPARC

References

  1. Evolutionary conservation and association of SPARC with the basal lamina in Drosophila. Martinek, N., Zou, R., Berg, M., Sodek, J., Ringuette, M. Dev. Genes Evol. (2002) [Pubmed]
  2. A Drosophila gene encoding multiple splice variants of Kazal-type serine protease inhibitor-like proteins with potential destinations of mitochondria, cytosol and the secretory pathway. Niimi, T., Yokoyama, H., Goto, A., Beck, K., Kitagawa, Y. Eur. J. Biochem. (1999) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities