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Gene Review

MPP2  -  membrane protein, palmitoylated 2 (MAGUK...

Homo sapiens

Synonyms: DKFZp761D0712, DLG2, Discs large homolog 2, MAGUK p55 subfamily member 2, Protein MPP2
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Disease relevance of MPP2

  • No evidence for mutation was found, making it unlikely that DLG2 is involved in sporadic breast cancer [1].
  • Since allelic loss has been reported in the 17q12-q21 region in breast and ovarian cancer and it appears that BRCA1 is not the target of the losses, we looked for somatic alterations in DLG2 in sporadic breast tumors [1].

High impact information on MPP2

  • Sequence analysis indicates that the carboxyl terminus of human WIN has been previously isolated as a putative phosphorylation substrate, MPM2-reactive phosphoprotein 2 (MPP2); WIN may be regulated by phosphorylation [2].
  • These results suggest that PSZA11q14 may be considered a candidate gene for schizophrenia acting as an antisense regulator of DLG-2, which controls assembling functional N-methyl-D-aspartate (NMDA) receptors [3].
  • The DLG3 gene is located on chromosome 17, in the same segment, 17q12-q21, as the related gene, DLG2 [4].
  • The products of the DLG2 and DLG3 genes show 36% identity and 58% similarity to each other, and both show nearly 60% sequence similarity to p55, an erythroid phosphoprotein that is a component of the red cell membrane [4].


  1. A gene (DLG2) located at 17q12-q21 encodes a new homologue of the Drosophila tumor suppressor dIg-A. Mazoyer, S., Gayther, S.A., Nagai, M.A., Smith, S.A., Dunning, A., van Rensburg, E.J., Albertsen, H., White, R., Ponder, B.A. Genomics (1995) [Pubmed]
  2. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. Yao, K.M., Sha, M., Lu, Z., Wong, G.G. J. Biol. Chem. (1997) [Pubmed]
  3. Novel putative nonprotein-coding RNA gene from 11q14 displays decreased expression in brains of patients with schizophrenia. Polesskaya, O.O., Haroutunian, V., Davis, K.L., Hernandez, I., Sokolov, B.P. J. Neurosci. Res. (2003) [Pubmed]
  4. Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21. Smith, S.A., Holik, P., Stevens, J., Mazoyer, S., Melis, R., Williams, B., White, R., Albertsen, H. Genomics (1996) [Pubmed]
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