Disease relevance of MPP3

• These results suggest that TSLC1 and MPP3 are involved in the same cascade of cell-cell interaction, and that the disruption of this cascade might lead cells to malignant growth and tumor formation in lung cancer [1].

High impact information on MPP3

• However, little is known about the other two genes in this cascade, DAL-1 and MPP3 [2].
• By contrast, MPP3 expression was found in all tumor cell lines analysed [2].
• Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg [1].
• The MPP3 gene was expressed in normal lung as well as in many tissues examined except for peripheral blood lymphocytes but lost its expression in one of the nine NSCLC cell lines [1].
• The DLG3 gene is located on chromosome 17, in the same segment, 17q12-q21, as the related gene, DLG2 [3].

Biological context of MPP3

• Furthermore, TSLC1 and MPP3 were colocalized at the cell-cell attachment sites in both a low and a high cell density [1].
• Isolation of a gene (DLG3) encoding a second member of the discs-large family on chromosome 17q12-q21 [3].
• The putative DLG3 gene product has a molecular weight of 66 kDa and contains a discs-large homologous region, a src oncogene homology motif 3, and a domain with homology to guanylate kinase [3].

Anatomical context of MPP3

• These data implicate a role for MPP3 in photoreceptor polarity and, by association with MPP5, pinpoint MPP3 as a functional candidate gene for inherited retinopathies [4].
• MPP3 localized at the photoreceptor synapse and at the subapical region adjacent to adherens junctions at the OLM [4].
• The products of the DLG2 and DLG3 genes show 36% identity and 58% similarity to each other, and both show nearly 60% sequence similarity to p55, an erythroid phosphoprotein that is a component of the red cell membrane [3].

Other interactions of MPP3

• MPP3 is recruited to the MPP5 protein scaffold at the retinal outer limiting membrane [4].

References