The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

CecA2  -  Cecropin A2

Drosophila melanogaster

Synonyms: CG1367, Cec, Cec A2, CecA, Dmel\CG1367, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

Disease relevance of CecA2

  • Cecropin A, the common product of the CecA1 and A2 genes, was identified in the hemolymph of immunized flies at a concentration of 25-50 microM, enough to kill all tested bacteria except Serratia, a Drosophila pathogen [1].
 

High impact information on CecA2

  • Through GmmRel knock-down, we could successfully block the induction of attacin and cecropin expression in the immune responsive tissues fat body and proventriculus (cardia) following microbial challenge [2].
  • The imd gene is required for local Cecropin expression in Drosophila barrier epithelia [3].
  • We show that the upstream region of the Cecropin gene CecA1 contains elements responsible for inducible and tissue-specific expression [4].
  • The interspecific comparison has revealed that in the three species of the simulans cluster the CecA2 gene is partially deleted and has therefore lost its function and become a pseudogene; in each of the species, subsequent deletions have accumulated [5].
  • Of the four putative novel defence proteins (DFPs) annotated by PSI-BLAST three showed similarity to extracellular matrix proteins from vertebrates implicated in innate immunity, while the fourth was similar to, yet distinct from, the anti-microbial protein cecropin [6].

References

  1. The immune response in Drosophila: pattern of cecropin expression and biological activity. Samakovlis, C., Kimbrell, D.A., Kylsten, P., Engström, A., Hultmark, D. EMBO J. (1990) [Pubmed]
  2. Innate immune responses regulate trypanosome parasite infection of the tsetse fly Glossina morsitans morsitans. Hu, C., Aksoy, S. Mol. Microbiol. (2006) [Pubmed]
  3. The imd gene is required for local Cecropin expression in Drosophila barrier epithelia. Onfelt Tingvall, T., Roos, E., Engström, Y. EMBO Rep. (2001) [Pubmed]
  4. kappa B-like motifs regulate the induction of immune genes in Drosophila. Engström, Y., Kadalayil, L., Sun, S.C., Samakovlis, C., Hultmark, D., Faye, I. J. Mol. Biol. (1993) [Pubmed]
  5. Molecular evolution of the Cecropin multigene family in Drosophila. functional genes vs. pseudogenes. Ramos-Onsins, S., Aguadé, M. Genetics (1998) [Pubmed]
  6. Analysis of bacteria-challenged wild silkmoth, Antheraea mylitta (lepidoptera) transcriptome reveals potential immune genes. Gandhe, A.S., Arunkumar, K.P., John, S.H., Nagaraju, J. BMC Genomics (2006) [Pubmed]
 
WikiGenes - Universities