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Gene Review

TRIM67  -  tripartite motif containing 67

Homo sapiens

Synonyms: TNL, TRIM9-like protein, Tripartite motif-containing protein 67
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Disease relevance of TRIM67

  • PATIENTS: Plasma samples were collected at term in the absence of labor (TNL; n = 27; 39.3 +/- 0.1 gestational weeks), at term spontaneous vaginal delivery (TL; n = 24; 40.1 +/- 0.2 gestational weeks), and at preterm labor (PTL; n = 19; 32.4 +/- 0.4 gestational weeks) [1].
  • RNA for cDNA probe synthesis was isolated from reflected human amnion and choriodecidua membranes delivered following Caesarean section at term before the onset of labour (TNL, n = 4), spontaneous labour at term (TSL, n = 4), and PTL with and without chorioamnionitis (PTL(+INF) and PTL(-INF) respectively, n = 4 each) [2].

High impact information on TRIM67

  • Changes in urocortin mRNA expression were also evaluated in placentas collected from TNL (n = 11), TL (n = 11), and PTL (n = 10) [1].
  • Two new EPR approaches were developed for determination of rate constants of reaction glutathione (GSH), N-(2-mercaptopropionyl) glycine (MPG), dihydrolipoic acid (BNL), and tetranor-dihydrolipoic acid (TNL) with superoxide radical [3].
  • Theonellapeptolide-Id (TNLP), a cyclic tridecapeptide lactone, was crystallized from dimethylformamide-water solution [4].
  • This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies [5].
  • Dibenzyl-g-butyrolactone and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactone (TNL) derivatives were synthesized and evaluated for cytotoxic activity against some cancer cell lines [6].

Associations of TRIM67 with chemical compounds

  • It was found that TNL derivatives with a shorter distance between C-4 in ring A and C'-2 in ring C were more cytotoxic, while dibenzyl-gamma-butyrolactones with a longer one were nearly inactive [6].

Analytical, diagnostic and therapeutic context of TRIM67

  • To evaluate whether PPAR-alpha and -delta subtypes are present in intrauterine tissues, placentae were obtained from women at term after spontaneous vaginal delivery (TSL; n = 15) and elective caesarean section before labor (TNL; n = 15) [7].


  1. High fetal urocortin levels at term and preterm labor. Florio, P., Torricelli, M., Galleri, L., De Falco, G., Leucci, E., Calonaci, G., Picciolini, E., Ambrosini, G., Linton, E.A., Petraglia, F. J. Clin. Endocrinol. Metab. (2005) [Pubmed]
  2. Use of cDNA arrays to generate differential expression profiles for inflammatory genes in human gestational membranes delivered at term and preterm. Marvin, K.W., Keelan, J.A., Eykholt, R.L., Sato, T.A., Mitchell, M.D. Mol. Hum. Reprod. (2002) [Pubmed]
  3. Determination of rate constants of the reactions of thiols with superoxide radical by electron paramagnetic resonance: critical remarks on spectrophotometric approaches. Dikalov, S., Khramtsov, V., Zimmer, G. Arch. Biochem. Biophys. (1996) [Pubmed]
  4. Amphipathic structure of theonellapeptolide-Id, a hydrophobic tridecapeptide lactone from the Okinawa marine sponge Theonella swinhoei. Doi, M., Ishida, T., Kobayashi, M., Katsuya, Y., Mezaki, Y., Sasaki, M., Terashima, A., Taniguchi, T., Tanaka, C. Biopolymers (2000) [Pubmed]
  5. Plant NBS-LRR proteins: adaptable guards. McHale, L., Tan, X., Koehl, P., Michelmore, R.W. Genome Biol. (2006) [Pubmed]
  6. 2,3-dibenzylbutyrolactones and 1,2,3,4-tetrahydro-2-naphthoic acid gamma-lactones: structure and activity relationship in cytotoxic activity. Kim, Y., You, Y.J., Nam, N.H., Ahn, B.Z. Arch. Pharm. Res. (2002) [Pubmed]
  7. Peroxisome proliferator-activated receptor isoform expression changes in human gestational tissues with labor at term. Berry, E.B., Eykholt, R., Helliwell, R.J., Gilmour, R.S., Mitchell, M.D., Marvin, K.W. Mol. Pharmacol. (2003) [Pubmed]
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