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Gene Review

ome  -  omega

Drosophila melanogaster

Synonyms: BEST:LD21715, CG17705, CG32143, CG32145, CG42280, ...
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High impact information on ome

  • The Omega class of cytosolic glutathione transferases was initially recognized by bioinformatic analysis of human sequence databases, and orthologous sequences were subsequently discovered in mouse, rat, pig, Caenorhabditis elegans, Schistosoma mansoni, and Drosophila melanogaster [1].
  • We have investigated the centrosome cycle in Drosophila syncytial embryos at the ultrastructural level by using a transmission electron microscope equipped with an electron energy filtering device (Omega filter) [2].
  • All cloned and expressed candidates exhibited relatively high thiol transferase and dehydroascorbate reductase activities and low activity towards 1-chloro-2,4-dinitrobenzene, characteristic of Omega class GSTs, whereas only CG6781 catalysed the synthesis of PDA in vitro [3].
  • In conclusion, we have discovered a new catalytic activity for an Omega class GST and that CG6781 is the structural gene for sepia which encodes PDA synthase [3].
  • A homozygote null mutant (ome 1) shows a pleiotropic phenotype that affected the size, developmental time of the flies, and the fertility (or perhaps the behavior) of homozygous mutant males [4].

Biological context of ome

  • The identity of the gene was confirmed as CG32145 (cytology 70F4) in the Celera Database (Berkeley Drosophila Genome Project), which is consistent with its deletion map position [4].

Other interactions of ome


  1. Characterization of the omega class of glutathione transferases. Whitbread, A.K., Masoumi, A., Tetlow, N., Schmuck, E., Coggan, M., Board, P.G. Meth. Enzymol. (2005) [Pubmed]
  2. The centrosome cycle in syncytial Drosophila embryos analyzed by energy filtering transmission electron microscopy. Debec, A., Marcaillou, C., Bobinnec, Y., Borot, C. Biol. Cell (1999) [Pubmed]
  3. Identification and characteristics of the structural gene for the Drosophila eye colour mutant sepia, encoding PDA synthase, a member of the Omega class glutathione S-transferases. Kim, J., Suh, H., Kim, S., Kim, K., Ahn, C., Yim, J. Biochem. J. (2006) [Pubmed]
  4. Identification and partial characterization of the enzyme of omega: one of five putative DPP IV genes in Drosophila melanogaster. Chihara, C.J., Song, C., LaMonte, G., Fetalvero, K., Hinchman, K., Phan, H., Pineda, M., Robinson, K., Schneider, G.P. J. Insect Sci. (2005) [Pubmed]
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