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Gene Review

Lcp1  -  Larval cuticle protein 1

Drosophila melanogaster

Synonyms: CG11650, CP1, DMLCP1, DmelLcp1, Dmel\CG11650, ...
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Disease relevance of Lcp1


High impact information on Lcp1


Biological context of Lcp1


Anatomical context of Lcp1

  • In larvae the cellular immune response involves circulating cells (hemocytes) that can be recruited from a hematopoietic organ located behind the brain, as well as a sessile population found just underneath the larval cuticle [9].
  • Genetic analysis of both null and hypomorphic gbb alleles indicates that the gene is required in many developmental processes, including embryonic midgut morphogenesis, patterning of the larval cuticle, fat body morphology, and development and patterning of the imaginal discs [10].
  • In a genetic screen for Tribolium mutants affecting the larval cuticle pattern, we isolated 4 mutants (from a total of 30) which disrupt segmentation in the thorax and abdomen [11].

Associations of Lcp1 with chemical compounds


Other interactions of Lcp1

  • The Beagle element appears to inactivate the LCP-3 gene by inserting into its TATA box, but also may cause the precocious expression of two other LCP genes, LCP-1 and LCP-f2, in the cluster [8].
  • Using the HUDSON, KREITMAN, and AGUADE (HKA) test, we show that the level of polymorphism in Lcp psi within D. melanogaster is lower than expected given the amount of divergence between D. melanogaster and D. simulans when the pseudogene data are compared to the Adh 5' flanking region [13].
  • We show that zygotic mutations in several individual secretory pathway genes result in larval cuticle phenotypes nearly identical to those of CrebA mutants [14].
  • The Drosophila Pax gene paired encodes a transcription factor that is required for the activation of segment-polarity genes and proper segmentation of the larval cuticle, postembryonic viability and male fertility [15].
  • Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila [16].


  1. RacGap50C negatively regulates wingless pathway activity during Drosophila embryonic development. Jones, W.M., Bejsovec, A. Genetics (2005) [Pubmed]
  2. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Gertler, F.B., Bennett, R.L., Clark, M.J., Hoffmann, F.M. Cell (1989) [Pubmed]
  3. A gap gene, hunchback, regulates the spatial expression of Ultrabithorax. White, R.A., Lehmann, R. Cell (1986) [Pubmed]
  4. The cuticle genes of drosophila: a developmentally regulated gene cluster. Snyder, M., Hirsh, J., Davidson, N. Cell (1981) [Pubmed]
  5. How Y chromosomes become genetically inert. Steinemann, M., Steinemann, S., Lottspeich, F. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  6. Degenerating Y chromosome of Drosophila miranda: a trap for retrotransposons. Steinemann, M., Steinemann, S. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  7. Evolution of the larval cuticle proteins coded by the secondary sex chromosome pair: X2 and neo-Y of Drosophila miranda: I. Comparison at the DNA sequence level. Steinemann, M., Steinemann, S., Pinsker, W. J. Mol. Evol. (1996) [Pubmed]
  8. Regulation of larval cuticle protein gene expression in Drosophila melanogaster. Kimbrell, D.A., Tojo, S.J., Alexander, S., Brown, E.E., Tobin, S.L., Fristrom, J.W. Dev. Genet. (1989) [Pubmed]
  9. Reciprocal regulation of Rac1 and Rho1 in Drosophila circulating immune surveillance cells. Williams, M.J., Habayeb, M.S., Hultmark, D. J. Cell. Sci. (2007) [Pubmed]
  10. Genetic analysis of the bone morphogenetic protein-related gene, gbb, identifies multiple requirements during Drosophila development. Wharton, K.A., Cook, J.M., Torres-Schumann, S., de Castro, K., Borod, E., Phillips, D.A. Genetics (1999) [Pubmed]
  11. Pair-rule and gap gene mutants in the flour beetle Tribolium castaneum. Maderspacher, F., Bucher, G., Klingler, M. Dev. Genes Evol. (1998) [Pubmed]
  12. Purification and cDNA cloning of evolutionally conserved larval cuticle proteins of the silkworm, Bombyx mori. Nakato, H., Takekoshi, M., Togawa, T., Izumi, S., Tomino, S. Insect Biochem. Mol. Biol. (1997) [Pubmed]
  13. Polymorphism and divergence at a Drosophila pseudogene locus. Pritchard, J.K., Schaeffer, S.W. Genetics (1997) [Pubmed]
  14. CrebA regulates secretory activity in the Drosophila salivary gland and epidermis. Abrams, E.W., Andrew, D.J. Development (2005) [Pubmed]
  15. Dual role of the Pax gene paired in accessory gland development of Drosophila. Xue, L., Noll, M. Development (2002) [Pubmed]
  16. Antagonism between EGFR and Wingless signalling in the larval cuticle of Drosophila. Szüts, D., Freeman, M., Bienz, M. Development (1997) [Pubmed]
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