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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Schistosoma


Psychiatry related information on Schistosoma


High impact information on Schistosoma

  • The homologous protein from Schistosoma mansoni, SPRM1, also associates covalently with coexpressed h4F2hc glycoprotein, although it induces amino-acid transport of different substrate specificity [8].
  • We have previously reported the production of a rat monoclonal IgG2a antibody against Schistosoma mansoni which exhibits marked cytoxicity for schistosomula in the presence of eosinophils and a high degree of protection by passive transfer in naive rats [9].
  • Serotonin-activated adenylate cyclase during early development of Schistosoma mansoni [10].
  • Consistent with these biochemical defects, Itk-/- mice did not generate effective TH2 responses when challenged with Schistosoma mansoni eggs [11].
  • Development of secondary pulmonary granulomata in response to Schistosoma mansoni eggs was blunted in MCP-1(-/-) mice, as was expression of IL-4, IL-5, and interferon gamma in splenocytes [12].

Chemical compound and disease context of Schistosoma

  • Functional angiotensin II receptors on macrophages from isolated liver granulomas of murine Schistosoma mansoni [13].
  • Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression [14].
  • Lung granuloma formation generated in mice by embolization of Schistosoma mansoni eggs was markedly suppressed by treatment with the stable, functional analog of prostaglandin E, (PGE1), (15-(S)-15-methyl PGE1) while treatment with PGF2 alpha augmented the granulomatous response [15].
  • This paper reports the crystal structure of the Schistosoma haematobium 28 kDa glutathione S-transferase, a multifunctional enzyme involved in host-parasite interactions and presently considered as a promising vaccine candidate against schistosomiasis [16].
  • Furthermore, inhibitors of oxidative metabolism and arginine supplementation did not prevent this toxicity, suggesting that the mechanism of microfilarial damage differs from that seen with another multicellular helminth, Schistosoma mansoni [17].

Biological context of Schistosoma


Anatomical context of Schistosoma


Associations of Schistosoma with chemical compounds


Gene context of Schistosoma

  • However, it was unexpectedly found that mice with targeted deletion of the P-selectin gene (PsKO mice) developed unpolarized type 1/type 2 cytokine responses and severely aggravated liver pathology following infection with the type 2-promoting pathogen Schistosoma mansoni [33].
  • Mice infected with Schistosoma mansoni develop polarized Th2 responses in which Th1 responses are prevented by IL-10-mediated suppression of IL-12 production [34].
  • In this study, we examined the role of TGF-beta in IL-13-dependent liver fibrosis caused by Schistosoma mansoni infection [35].
  • The folding of the peptide chain is very similar to that of Schistosoma mansoni and previous yeast hexokinase models despite only 30% sequence identity between them [36].
  • This work concerns the functional characterization of SER, the EGF-R-like molecule previously identified in the helminth parasite Schistosoma mansoni [37].

Analytical, diagnostic and therapeutic context of Schistosoma


  1. Regulation and function of the interleukin 13 receptor alpha 2 during a T helper cell type 2-dominant immune response. Chiaramonte, M.G., Mentink-Kane, M., Jacobson, B.A., Cheever, A.W., Whitters, M.J., Goad, M.E., Wong, A., Collins, M., Donaldson, D.D., Grusby, M.J., Wynn, T.A. J. Exp. Med. (2003) [Pubmed]
  2. Role of lipoxygenase products in murine pulmonary granuloma formation. Kunkel, S.L., Chensue, S.W., Mouton, C., Higashi, G.I. J. Clin. Invest. (1984) [Pubmed]
  3. Elevated serum levels and reduced immunohistochemical expression of thrombomodulin in active ulcerative colitis. Boehme, M.W., Autschbach, F., Zuna, I., Scherbaum, W.A., Stange, E., Raeth, U., Sieg, A., Stremmel, W. Gastroenterology (1997) [Pubmed]
  4. Induction of mucosal immune responses against a heterologous antigen fused to filamentous hemagglutinin after intranasal immunization with recombinant Bordetella pertussis. Renauld-Mongénie, G., Mielcarek, N., Cornette, J., Schacht, A.M., Capron, A., Riveau, G., Locht, C. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  5. Ablation of eosinophil and IgE responses with anti-IL-5 or anti-IL-4 antibodies fails to affect immunity against Schistosoma mansoni in the mouse. Sher, A., Coffman, R.L., Hieny, S., Cheever, A.W. J. Immunol. (1990) [Pubmed]
  6. Schistosoma mansoni: effects of bromolysergic acid diethylamide, verapamil, and Ca2+-free solution on the motor activity of the isolated male worm induced by electrical stimulation and oxamniquine. Soares de Moura, R., Rozental, R., Claudio-da-Silva, T.S. Exp. Parasitol. (1987) [Pubmed]
  7. Poor patient compliance reduces the efficacy of metrifonate treatment of Schistosoma haematobium in Somalia. Aden Abdi, Y., Gustafsson, L.L. Eur. J. Clin. Pharmacol. (1989) [Pubmed]
  8. Amino-acid transport by heterodimers of 4F2hc/CD98 and members of a permease family. Mastroberardino, L., Spindler, B., Pfeiffer, R., Skelly, P.J., Loffing, J., Shoemaker, C.B., Verrey, F. Nature (1998) [Pubmed]
  9. An anti-idiotype vaccine against experimental schistosomiasis. Grzych, J.M., Capron, M., Lambert, P.H., Dissous, C., Torres, S., Capron, A. Nature (1985) [Pubmed]
  10. Serotonin-activated adenylate cyclase during early development of Schistosoma mansoni. Kasschau, M.R., Mansour, T.E. Nature (1982) [Pubmed]
  11. Mutation of Tec family kinases alters T helper cell differentiation. Schaeffer, E.M., Yap, G.S., Lewis, C.M., Czar, M.J., McVicar, D.W., Cheever, A.W., Sher, A., Schwartzberg, P.L. Nat. Immunol. (2001) [Pubmed]
  12. Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient mice. Lu, B., Rutledge, B.J., Gu, L., Fiorillo, J., Lukacs, N.W., Kunkel, S.L., North, R., Gerard, C., Rollins, B.J. J. Exp. Med. (1998) [Pubmed]
  13. Functional angiotensin II receptors on macrophages from isolated liver granulomas of murine Schistosoma mansoni. Weinstock, J.V., Kassab, J.T. J. Immunol. (1984) [Pubmed]
  14. Macrophage function in the Schistosoma mansoni egg-induced pulmonary granuloma. Role of arachidonic acid metabolites in macrophage Ia antigen expression. Kunkel, S.L., Chensue, S.W., Plewa, M., Higashi, G.I. Am. J. Pathol. (1984) [Pubmed]
  15. Exogenously administered prostaglandins modulate pulmonary granulomas induced by Schistosoma mansoni eggs. Chensue, S.W., Kunkel, S.L., Ward, P.A., Higashi, G.I. Am. J. Pathol. (1983) [Pubmed]
  16. Crystal structure of the 28 kDa glutathione S-transferase from Schistosoma haematobium. Johnson, K.A., Angelucci, F., Bellelli, A., Hervé, M., Fontaine, J., Tsernoglou, D., Capron, A., Trottein, F., Brunori, M. Biochemistry (2003) [Pubmed]
  17. Lack of biological significance of in vitro Brugia malayi microfilarial cytotoxicity mediated by Propionibacterium acnes ("Corynebacterium parvum")-and Mycobacterium bovis BCG-activated macrophages. Fanning, M.M., Kazura, J.W. Infect. Immun. (1986) [Pubmed]
  18. Acquisition of murine major histocompatibility complex gene products by schistosomula of Schistosoma mansoni. Sher, A., Hall, B.F., Vadas, M.A. J. Exp. Med. (1978) [Pubmed]
  19. Downregulation of Th1 cytokine production accompanies induction of Th2 responses by a parasitic helminth, Schistosoma mansoni. Pearce, E.J., Caspar, P., Grzych, J.M., Lewis, F.A., Sher, A. J. Exp. Med. (1991) [Pubmed]
  20. Gene expression of transforming growth factor beta 1 and extracellular matrix proteins in murine Schistosoma mansoni infection. Kresina, T.F., He, Q., Degli Esposti, S., Zern, M.A. Gastroenterology (1994) [Pubmed]
  21. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interferon gamma-induced activation. Oswald, I.P., Wynn, T.A., Sher, A., James, S.L. Proc. Natl. Acad. Sci. U.S.A. (1992) [Pubmed]
  22. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. Hoffmann, K.F., James, S.L., Cheever, A.W., Wynn, T.A. J. Immunol. (1999) [Pubmed]
  23. Evidence that cytokine-mediated immune interactions induced by Schistosoma mansoni alter disease outcome in mice concurrently infected with Trichuris muris. Curry, A.J., Else, K.J., Jones, F., Bancroft, A., Grencis, R.K., Dunne, D.W. J. Exp. Med. (1995) [Pubmed]
  24. Carcinogenicity of the antischistosomal nitrofuran trans-5-amino-3-[2-(5-nitro-2-furyl)vinyl]-1,2,4-oxadiazole. Dunsford, H.A., Keysser, C.H., Dolan, P.M., Seed, J.L., Bueding, E. J. Natl. Cancer Inst. (1984) [Pubmed]
  25. Schistosomula of Schistosoma mansoni use lysophosphatidylcholine to lyse adherent human red blood cells and immobilize red cell membrane components. Golan, D.E., Brown, C.S., Cianci, C.M., Furlong, S.T., Caulfield, J.P. J. Cell Biol. (1986) [Pubmed]
  26. Major histocompatibility complex products restrict the adherence of cytolytic T lymphocytes to minor histocompatibility antigens or to trinitrophenyl determinants on schistosomula of Schistosoma mansoni. Vadas, M.A., Butterworth, A.E., Burakoff, S., Sher, A. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  27. Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens. Szala, S., Kasai, Y., Steplewski, Z., Rodeck, U., Koprowski, H., Linnenbach, A.J. Proc. Natl. Acad. Sci. U.S.A. (1990) [Pubmed]
  28. Carcinogenic effects of niridazole on rodents infected with Schistosoma mansoni. Bulay, O., Urman, H., Clayson, D.B., Shubik, P. J. Natl. Cancer Inst. (1977) [Pubmed]
  29. Experimental biharzial bladder cancer: tryptophan metabolism in nonhuman primates experimentally infected with Schistosoma haematobium. Brown, R.R., Kuntz, R.E., Arend, R.A., Moore, J.A., Huang, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  30. Effect of SQ 14225, an inhibitor of angiotensin I-converting enzyme, on the granulomatous response to Schistosoma mansoni eggs in mice. Weinstock, J.V., Ehrinpreis, M.N., Boros, D.L., Gee, J.B. J. Clin. Invest. (1981) [Pubmed]
  31. Induced and spontaneous diabetes mellitus and suppression of cell-mediated immunologic responses. Granuloma formation, delayed dermal reactivity and allograft rejection. Mahmoud, A.A., Rodman, H.M., Mandel, M.A., Warren, K.S. J. Clin. Invest. (1976) [Pubmed]
  32. Hycanthone dose-response in Schistosoma mansoni infection in Kenya. Warren, K.S., Siongok, T.K., Ouma, J.H., Houser, H.B. Lancet (1978) [Pubmed]
  33. P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor. Wynn, T.A., Hesse, M., Sandler, N.G., Kaviratne, M., Hoffmann, K.F., Chiaramonte, M.G., Reiman, R., Cheever, A.W., Sypek, J.P., Mentink-Kane, M.M. Hepatology (2004) [Pubmed]
  34. CD25+CD4+ cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. McKee, A.S., Pearce, E.J. J. Immunol. (2004) [Pubmed]
  35. IL-13 activates a mechanism of tissue fibrosis that is completely TGF-beta independent. Kaviratne, M., Hesse, M., Leusink, M., Cheever, A.W., Davies, S.J., McKerrow, J.H., Wakefield, L.M., Letterio, J.J., Wynn, T.A. J. Immunol. (2004) [Pubmed]
  36. The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. Kuser, P.R., Krauchenco, S., Antunes, O.A., Polikarpov, I. J. Biol. Chem. (2000) [Pubmed]
  37. Conservation of epidermal growth factor receptor function in the human parasitic helminth Schistosoma mansoni. Vicogne, J., Cailliau, K., Tulasne, D., Browaeys, E., Yan, Y.T., Fafeur, V., Vilain, J.P., Legrand, D., Trolet, J., Dissous, C. J. Biol. Chem. (2004) [Pubmed]
  38. Molecular cloning and sequence analysis of 3-hydroxy-3-methylglutaryl-coenzyme A reductase from the human parasite Schistosoma mansoni. Rajkovic, A., Simonsen, J.N., Davis, R.E., Rottman, F.M. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  39. Vaccination routes that fail to elicit protective immunity against Schistosoma mansoni induce the production of TGF-beta, which down-regulates macrophage antiparasitic activity. Williams, M.E., Caspar, P., Oswald, I., Sharma, H.K., Pankewycz, O., Sher, A., James, S.L. J. Immunol. (1995) [Pubmed]
  40. The hypoxanthine-guanine phosphoribosyltransferase of Schistosoma mansoni. Further characterization and gene expression in Escherichia coli. Yuan, L., Craig, S.P., McKerrow, J.H., Wang, C.C. J. Biol. Chem. (1990) [Pubmed]
  41. Intranasal administration of a Schistosoma mansoni glutathione S-transferase-cholera toxoid conjugate vaccine evokes antiparasitic and antipathological immunity in mice. Sun, J.B., Mielcarek, N., Lakew, M., Grzych, J.M., Capron, A., Holmgren, J., Czerkinsky, C. J. Immunol. (1999) [Pubmed]
  42. Glycopeptides in soluble egg antigen of Schistosoma mansoni: isolation, characterization, and elucidation of their immunochemical and immunopathological relation to the major egg glycoprotein (MEG). Lustigman, S., Mahmoud, A.A., Hamburger, J. J. Immunol. (1985) [Pubmed]
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