Disease relevance of IL12

• Interleukin-12 from intrinsic cells is an effector of renal injury in crescentic glomerulonephritis [1].
• Interleukin-12 is critical for induction of nitric oxide-mediated immunosuppression following vaccination of mice with attenuated Salmonella typhimurium [2].
• Molecular and immunological characterisation of recombinant Brucella abortus glyceraldehyde-3-phosphate-dehydrogenase, a T- and B-cell reactive protein that induces partial protection when co-administered with an interleukin-12-expressing plasmid in a DNA vaccine formulation [3].

High impact information on IL12

• Interleukin-12 up-regulates the induction of an antigen-specific antibody response in cultures of human lymphocytes [4].
• The influence of interleukin-12 (IL-12) on the induction of a specific antibody response to the T-dependent antigen sheep erythrocytes (SRBC) in cultures of human blood lymphocytes was investigated [4].
• Central to these studies are the roles of interferon-gamma, interleukin-12 and activated macrophages with the involvement of nitric oxide in parasite killing [5].

Analytical, diagnostic and therapeutic context of IL12

• The present study investigated the role of interleukin-12 (IL-12) in the generation of nitric oxide-mediated immunosuppression in this model [2].

References