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Gene Review

IFNG  -  interferon, gamma

Ovis aries

 
 
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Disease relevance of IFNG

 

High impact information on IFNG

 

Biological context of IFNG

 

Anatomical context of IFNG

 

Associations of IFNG with chemical compounds

  • Intron 1 of the interferon gamma gene: Its role in nematode resistance in Suffolk and Texel sheep breeds [1].
  • Arteries incubated for 6 h with interferon-gamma (IFN-gamma, 10 ng ml(-1)) and tumour necrosis factor-alpha (TNF-alpha, 5 ng ml(-1)) exhibited greater relaxation to BK (E(max)-50.0+/-5.1%) than polymyxin B-treated controls (E(max)-33.1+/-4.0%), but did not differ in their response to PE [16].
  • Interferon gamma inhibits the intracellular multiplication of Neospora caninum, as shown by incorporation of 3H uracil [17].
  • In this study, the effect of Factor AF2 on mitogen-induced interferon-gamma release by PBMC was tested in 23 healthy humans and in 23 tumor patients [18].
  • Altering the nutrient composition of the cultures by addition of tryptophan partially reverses the antichlamydial effects of the IFN-gamma [19].
 

Regulatory relationships of IFNG

  • Many cells expressing messenger RNA (mRNA) encoding for tumour necrosis factor-alpha (TNF-alpha) were demonstrated, but few cells expressing interferon gamma mRNA and none expressing interleukin-4 mRNA were detected [20].
 

Other interactions of IFNG

 

Analytical, diagnostic and therapeutic context of IFNG

References

  1. Intron 1 of the interferon gamma gene: Its role in nematode resistance in Suffolk and Texel sheep breeds. Sayers, G., Good, B., Hanrahan, J.P., Ryan, M., Sweeney, T. Res. Vet. Sci. (2005) [Pubmed]
  2. Effect of dietary fish oil on development and selected functions of murine inflammatory macrophages. Hubbard, N.E., Somers, S.D., Erickson, K.L. J. Leukoc. Biol. (1991) [Pubmed]
  3. A novel mechanism of immune regulation: interferon-gamma regulates retention of CD4 T cells during delayed type hypersensitivity. Seabrook, T.J., Borron, P.J., Dudler, L., Hay, J.B., Young, A.J. Immunology (2005) [Pubmed]
  4. In-vitro susceptibility of hydatid cysts of Echinococcus granulosus to nitric oxide and the effect of the laminated layer on nitric oxide production. Steers, N.J., Rogan, M.T., Heath, S. Parasite Immunol. (2001) [Pubmed]
  5. A long-term study in Merino sheep experimentally infected with Mycobacterium avium subsp. paratuberculosis: clinical disease, faecal culture and immunological studies. Stewart, D.J., Vaughan, J.A., Stiles, P.L., Noske, P.J., Tizard, M.L., Prowse, S.J., Michalski, W.P., Butler, K.L., Jones, S.L. Vet. Microbiol. (2004) [Pubmed]
  6. Inhibition of macrophage priming by sulfatide from Mycobacterium tuberculosis. Pabst, M.J., Gross, J.M., Brozna, J.P., Goren, M.B. J. Immunol. (1988) [Pubmed]
  7. Modulation of c-myc oncogene expression by phorbol ester and interferon-gamma: appraisal by flow cytometry. Mohamed, A.N., Nakeff, A., Mohammad, R.M., KuKuruga, M., al-Katib, A. Oncogene (1988) [Pubmed]
  8. Induction of HLA-DR expression in endometrial epithelial cells by endometrial T-cells: potential regulatory role of endometrial T-cells in vivo. Tabibzadeh, S. J. Clin. Endocrinol. Metab. (1991) [Pubmed]
  9. Hyperoxic suppression of Fc-gamma receptor-mediated phagocytosis by isolated murine pulmonary macrophages. Crowell, R.E., Hallin, G., Heaphy, E., Mold, C. Am. J. Respir. Cell Mol. Biol. (1995) [Pubmed]
  10. Quantitative trait loci associated with parasitic infection in Scottish blackface sheep. Davies, G., Stear, M.J., Benothman, M., Abuagob, O., Kerr, A., Mitchell, S., Bishop, S.C. Heredity (2006) [Pubmed]
  11. Differential regulation of the immune response to SRBC by monoclonal antibodies to interferon-gamma. Helman, S.W., Wallace, J.H. Proc. Soc. Exp. Biol. Med. (1989) [Pubmed]
  12. The effect of recombinant interferon-gamma on human monocyte-derived macrophages. Jungi, T.W., Lerch, P.G., Brcic, M. Eur. J. Immunol. (1987) [Pubmed]
  13. Generation of an ovine bone marrow-derived myelomonocyte-like cell line by retroviral-mediated transformation. Immunological characterization and the effect of cytokines and lipopolysaccharides. John, H.A., Deane, D., Haig, D. J. Leukoc. Biol. (1994) [Pubmed]
  14. Intra-epithelial lymphocytes: interferon-gamma production and suppressor/cytotoxic activities. Ebert, E.C. Clin. Exp. Immunol. (1990) [Pubmed]
  15. The effect of cytokines and chemotactic agonists on the migration of T lymphocytes into skin. Colditz, I.G., Watson, D.L. Immunology (1992) [Pubmed]
  16. The role of nitric oxide in the responses of the ovine digital artery to vasoactive agents and modification of these responses by endotoxin and cytokines. Pawson, P., Reid, J., Nolan, A.M. Br. J. Pharmacol. (2000) [Pubmed]
  17. Interferon gamma inhibits the intracellular multiplication of Neospora caninum, as shown by incorporation of 3H uracil. Innes, E.A., Panton, W.R., Marks, J., Trees, A.J., Holmdahl, J., Buxton, D. J. Comp. Pathol. (1995) [Pubmed]
  18. Improvement of impaired mitogen-induced interferon-gamma release of peripheral blood mononuclear cells derived from tumor patients by Factor AF2. Baier, J.E., Neumann, H.A., Gallati, H., Ricken, D. Research in experimental medicine. Zeitschrift für die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie. (1991) [Pubmed]
  19. Cytokines and the protective host immune response to Chlamydia psittaci. Entrican, G., Brown, J., Graham, S. Comp. Immunol. Microbiol. Infect. Dis. (1998) [Pubmed]
  20. Ovine chlamydial abortion: characterization of the inflammatory immune response in placental tissues. Buxton, D., Anderson, I.E., Longbottom, D., Livingstone, M., Wattegedera, S., Entrican, G. J. Comp. Pathol. (2002) [Pubmed]
  21. Detecting the signature of selection on immune genes in highly structured populations of wild sheep (Ovis dalli). Worley, K., Carey, J., Veitch, A., Coltman, D.W. Mol. Ecol. (2006) [Pubmed]
  22. Variability in cytokine production and cell proliferation by mitogen-activated ovine peripheral blood mononuclear cells: modulation by interleukin (IL)-10 and IL-12. Wattegedera, S., Sills, K., Howard, C.J., Hope, J.C., McInnes, C.J., Entrican, G. Vet. Immunol. Immunopathol. (2004) [Pubmed]
  23. IgE, TNF alpha, IL1 beta, IL4 and IFN gamma gene polymorphisms in sheep selected for resistance to fleece rot and flystrike. Engwerda, C.R., Dale, C.J., Sandeman, R.M. Int. J. Parasitol. (1996) [Pubmed]
  24. Control of coccidiosis: lessons from other sporozoa. Cox, F.E. Int. J. Parasitol. (1998) [Pubmed]
  25. Interferon-gamma and interleukin-2 release by lymphocytes derived from the blood, mesenteric lymph nodes and intestines of normal sheep and those affected with paratuberculosis (Johne's disease). Burrells, C., Clarke, C.J., Colston, A., Kay, J.M., Porter, J., Little, D., Sharp, J.M. Vet. Immunol. Immunopathol. (1999) [Pubmed]
  26. Immunological characterization of a gammadelta T-cell stimulatory ligand on autologous monocytes. Sathiyaseelan, T., Naiman, B., Welte, S., Machugh, N., Black, S.J., Baldwin, C.L. Immunology (2002) [Pubmed]
  27. Relation between pathologic findings and cellular immune responses in sheep with naturally acquired paratuberculosis. Pérez, V., Tellechea, J., Corpa, J.M., Gutiérrez, M., García Marín, J.F. Am. J. Vet. Res. (1999) [Pubmed]
  28. Antigen-induced production of interferon-gamma in samples of peripheral lymph nodes from sheep experimentally inoculated with Mycobacterium avium subsp. paratuberculosis. Gwozdz, J.M., Thompson, K.G. Vet. Microbiol. (2002) [Pubmed]
 
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