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Gene Review

AGRP  -  agouti related protein homolog (mouse)

Ovis aries

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High impact information on AGRP

  • These results are consistent with the involvement of NPY, AGRP and POMC in mediating the reproductive neuroendocrine response to increased systemic nutritional feedback, and they support the hypothesis that hypothalamic responses to nutritional feedback are influenced by photoperiod in sheep [1].
  • These results demonstrate that AGRP stimulates food intake in sheep and highlights the important differences between this species and rodent models [2].
  • Secondly, using dual-labeled immunohistochemistry, we determined that there was both increased AGRP immunoreactivity and increased abundance of c-Fos immunoreactivity in AGRP neurons in the arcuate nucleus of fasted sheep [2].
  • A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery [2].
  • Gene expression for AGRP in the ARC was higher in HI than LI animals (453% of LI; P<0.05), but expression levels were similar for NPY, OB-Rb, CART and POMC [3].

Biological context of AGRP

  • Gene expression was first localised for cocaine- and amphetamine-regulated transcript (CART) and agouti-related peptide (AGRP) [4].

Anatomical context of AGRP

  • To this end, we studied the expression of agouti-related peptide (AGRP) (an endogenous antagonist of alpha-MSH) and cocaine- and amphetamine-regulated transcript (CART), which is co-localized within POMC cells of the arcuate nucleus (ARC) in rodents [5].
  • Thus, long-term changes in nutritional status have profound effects on the expression of AGRP and CART in the hypothalamus [5].

Associations of AGRP with chemical compounds


Other interactions of AGRP


Analytical, diagnostic and therapeutic context of AGRP

  • In situ hybridization was used to study the expression of POMC, AGRP and CART [5].
  • To investigate the role of orexigenic peptides in the regulation of feed intake, we first extracted messenger RNA from sheep that were fasted for 3 days, which was then used for PCR followed by cloning and sequencing to demonstrate the presence of hypothalamic AGRP expression [2].


  1. Hypothalamic responses to peripheral glucose infusion in food-restricted sheep are influenced by photoperiod. Archer, Z.A., Rhind, S.M., Findlay, P.A., Kyle, C.E., Barber, M.C., Adam, C.L. J. Endocrinol. (2005) [Pubmed]
  2. A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery. Wagner, C.G., McMahon, C.D., Marks, D.L., Daniel, J.A., Steele, B., Sartin, J.L. Neuroendocrinology (2004) [Pubmed]
  3. Contrasting effects of different levels of food intake and adiposity on LH secretion and hypothalamic gene expression in sheep. Archer, Z.A., Rhind, S.M., Findlay, P.A., Kyle, C.E., Thomas, L., Marie, M., Adam, C.L. J. Endocrinol. (2002) [Pubmed]
  4. Hypothalamic gene expression in sheep for cocaine- and amphetamine-regulated transcript, pro-opiomelanocortin, neuropeptide Y, agouti-related peptide and leptin receptor and responses to negative energy balance. Adam, C.L., Archer, Z.A., Findlay, P.A., Thomas, L., Marie, M. Neuroendocrinology (2002) [Pubmed]
  5. Differential expression of cocaine- and amphetamine-regulated transcript and agouti related-protein in chronically food-restricted sheep. Henry, B.A., Rao, A., Ikenasio, B.A., Mountjoy, K.G., Tilbrook, A.J., Clarke, I.J. Brain Res. (2001) [Pubmed]
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