Disease relevance of Appetite Regulation

• Effect of dehydroepiandrosterone on neurotransmitter levels and appetite regulation of the obese Zucker rat. The Obesity Research Program [1].
• CONCLUSIONS: An activation of the TNF system, together with reciprocal changes in plasma concentrations of two neuropeptides with opposing appetite regulation, that is increased concentrations of CCK-8s but lower levels of beta-endorphin, are associated with the presence of HIV wasting [2].
• The observation of NPY gene expression in brain regions involved in appetite regulation is consistent with the recognized importance of NPY in FI regulation in a variety of species, and with the chronic hyperphagia, characteristic of the broiler [3].
• The understanding of interactions between leptin and insulin and their roles in glucose and body weight regulation provides clues towards mechanisms underlying altered appetite regulation and increased risk of type 2 diabetes in low birth weight individuals [4].

Psychiatry related information on Appetite Regulation

• Moreover, data from experimental animals show that CRF may influence several processes known to be altered in the overall symptom complex of depression, including not only pituitary-adrenal function, but also motor activity, appetite regulation and sexual behavior [5].

High impact information on Appetite Regulation

• Constitutive ghrelin receptor activity as a signaling set-point in appetite regulation [6].
• Inadequate pharmacological tools, until recently, hindered the understanding of the roles of corticotropin-releasing factor (CRF) receptor subtypes in appetite regulation and gastrocolonic motor function [7].
• Apolipoprotein (apoA-IV) is a 376-residue exchangeable apolipoprotein that may play a number of important roles in lipid metabolism, including chylomicron assembly, reverse cholesterol transport, and appetite regulation [8].
• Other studies suggest that colipase or its proform, procolipase, may have additional functions in appetite regulation or in fat digestion during the newborn period when pancreatic triglyceride lipase is not expressed [9].
• Furthermore, estrogen has been implicated in appetite regulation [10].

Biological context of Appetite Regulation

• Plasma levels of insulin and leptin, two other hormones involved in appetite regulation, did not differ between genotypes; however, the relationship between food intake and circulating leptin was significantly less negative at B doses that preserved appetite [11].
• Hypothalamic serotonin (5-HT) is involved in appetite regulation and sympathetic stimulation of thermogenesis [12].
• We used two competitive, non-selective inhibitors of NO synthase (NOS), (NG-monomethyl-L-arginine ester [L-NMMA] and NG-nitro-L-arginine methyl ester [L-NAME]), to evaluate the role of NO mechanisms in the control of food intake in a marsupial model previously used in studies of appetite regulation [13].
• In the past 10 years, 3 new metabolic compounds, leptin, adiponectin, and ghrelin, involved in energy metabolism, body composition, and appetite regulation, have been discovered [14].

Associations of Appetite Regulation with chemical compounds

• Dietary effects on brain serotonin synthesis: relationship to appetite regulation [15].
• This compound, because of its potency and selectivity, may be useful in studies relating to the function of GABA-containing neurons in appetite regulation [16].
• It is possible that the maintenance of an adequate level of insulin sensitivity and glucose oxidation may affect appetite regulation by favoring a more efficient postprandial ghrelin reduction [17].
• Human and animal studies have implicated dopamine in appetite regulation, and family studies have shown that BMI has a strong genetic component [18].
• These findings suggest that nicotine affects appetite regulation, in part by modulation of LHA-DA and 5HT [19].

Gene context of Appetite Regulation

• These results suggest a novel role for relaxin-3 in appetite regulation [20].
• Corticotropin-releasing hormone (CRH) is a neuropeptide thought to play a role in appetite regulation [21].
• These preproorexin responses are in contrast to those seen with well-characterized orexigenic neuropeptides, such as NPY and AgRP, suggesting that appetite regulation may not be a significant physiological role of orexins [22].
• A role for agouti-related protein in appetite regulation in a species with continuous nutrient delivery [23].
• Therefore, many POMC-derived peptides could have important roles in appetite regulation and it seems unlikely that alphaMSH is the sole physiological ligand [24].

Analytical, diagnostic and therapeutic context of Appetite Regulation

• Following polysomnography, morning, fasted blood samples were evaluated for serum leptin and ghrelin (two key opposing hormones in appetite regulation), adiponectin, insulin, glucose, and lipid profile [25].

References