Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

LEP - leptin

Ovis aries

Perucatti, A. et al., O'Connor, D.M. et al.

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High impact information on LEP

FISH-mapping of LEP and SLC26A2 genes in sheep, goat and cattle R-banded chromosomes: comparison between bovine, ovine and caprine chromosome 4 (BTA4/OAR4/CHI4) and human chromosome 7 (HSA7) [1].

Chemical compound and disease context of LEP

Developmental changes in circulating and PAT leptin may mediate the maturational effects of cortisol in utero and have long-term consequences for appetite regulation and the development of obesity [2].

Analytical, diagnostic and therapeutic context of LEP

Sheep (OAR), goat (CHI) and cattle (BTA) R-banded chromosome preparations, obtained from synchronized cell cultures, were used to FISH-map leptin (LEP) and solute carrier family 26 member 2 (SLC26A2) genes on single chromosome bands [1].

References

FISH-mapping of LEP and SLC26A2 genes in sheep, goat and cattle R-banded chromosomes: comparison between bovine, ovine and caprine chromosome 4 (BTA4/OAR4/CHI4) and human chromosome 7 (HSA7). Perucatti, A., Di Meo, G.P., Vallinoto, M., Kierstein, G., Schneider, M.P., Incarnato, D., Caputi Jambrenghi, A., Mohammadi, G., Vonghia, G., Silva, A., Brenig, B., Iannuzzi, L. Cytogenet. Genome Res. (2006) [Pubmed]
Developmental control of plasma leptin and adipose leptin messenger ribonucleic acid in the ovine fetus during late gestation: role of glucocorticoids and thyroid hormones. O'Connor, D.M., Blache, D., Hoggard, N., Brookes, E., Wooding, F.B., Fowden, A.L., Forhead, A.J. Endocrinology (2007) [Pubmed]

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