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Gene Review

LOC443566  -  shisa

Xenopus laevis

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High impact information on LOC443566


Biological context of LOC443566


Associations of LOC443566 with chemical compounds

  • The extracellular Cys-rich domain with eight Cys residues was conserved among vertebrate Shisa orthologs [2].

Other interactions of LOC443566

  • (2005) identifies a new protein termed Shisa that inhibits both Wnt- and FGF-signaling pathways during Xenopus gastrulation by mediating ER retention of the Wnt receptor Frizzled and the FGF receptor [3].


  1. Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., Aizawa, S. Cell (2005) [Pubmed]
  2. Comparative genomics on Shisa orthologs. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
  3. ER retention of signaling modules. Schlesinger, A., Shilo, B.Z. Dev. Cell (2005) [Pubmed]
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