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Gene Review:

LOC443566 - shisa

Xenopus laevis

Katoh, Y. et al., Yamamoto, A. et al., Schlesinger, A. et al.

Yamamoto, Nagano, Takehara, Hibi, Aizawa,

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High impact information on LOC443566

We identified a novel antagonist against Wnt and FGF signaling for head formation, Shisa, which functions cell autonomously in the endoplasmic reticulum (ER) [1].
Shisa is specifically expressed in the prospective head ectoderm and the Spemann organizer of Xenopus gastrulae [1].
Overexpression of Shisa inhibited both Wnt and FGF signaling in Xenopus embryos and in a cell line [1].
Comparative genomics on Shisa orthologs [2].
Shisa gene at rat chromosome 15p12 was found to encode a type I transmembrane protein (295 aa), showing 99.3, 92.5, 81.7, 40.3 and 38.6% total-amino-acid identity with mouse Shisa, human SHISA, chicken shisa, Xenopus shisa and zebrafish shisa, respectively [2].

Biological context of LOC443566

This is the first report on the rat Shisa gene and on molecular evolution of Shisa orthologs [2].

Associations of LOC443566 with chemical compounds

The extracellular Cys-rich domain with eight Cys residues was conserved among vertebrate Shisa orthologs [2].

Other interactions of LOC443566

(2005) identifies a new protein termed Shisa that inhibits both Wnt- and FGF-signaling pathways during Xenopus gastrulation by mediating ER retention of the Wnt receptor Frizzled and the FGF receptor [3].

References

Shisa promotes head formation through the inhibition of receptor protein maturation for the caudalizing factors, Wnt and FGF. Yamamoto, A., Nagano, T., Takehara, S., Hibi, M., Aizawa, S. Cell (2005) [Pubmed]
Comparative genomics on Shisa orthologs. Katoh, Y., Katoh, M. Int. J. Mol. Med. (2005) [Pubmed]
ER retention of signaling modules. Schlesinger, A., Shilo, B.Z. Dev. Cell (2005) [Pubmed]

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