Gene Review:
LOC446007 - GASZ
Takifugu rubripes
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High impact information on LOC446007
- Northern and Western blot analyses detect frog Gasz expression only in testis and ovary [1].
- In frog oocytes, GASZ protein appears to localize to a cytoplasmic structure resembling the Balbiani body, a postulated mRNA transport organizer in the cytoplasm [1].
- The high evolutionary conservation and germ cell specificity suggest that GASZ plays an essential role in gametogenesis [1].
Analytical, diagnostic and therapeutic context of LOC446007
- In situ hybridization and immunohistochemical analyses show that frog Gasz mRNA and protein expression is confined to pachytene spermatocytes in the testis and to oocytes in the ovary [1].
- The data presented here are important for future studies of the physiological roles of GASZ using fish and amphibians as animal models [1].
References
- Identification and characterization of evolutionarily conserved pufferfish, zebrafish, and frog orthologs of GASZ. Yan, W., Ma, L., Zilinski, C.A., Matzuk, M.M. Biol. Reprod. (2004) [Pubmed]
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