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Gene Review:

pabpc1l - poly(A) binding protein, cytoplasmic 1-like

Xenopus (Silurana) tropicalis

Synonyms: epab, epabp, pabpc1l1

Wilkie, G.S. et al., Cosson, B. et al.

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High impact information on MGC89376

Recently, Xenopus laevis oocytes and early embryos were shown to contain a novel poly(A)-binding protein, ePABP, which has not been described in other organisms. ePABP was identified as a protein that binds AU-rich sequences and prevents shortening of poly(A) tails [1].
We show that ePABP is associated with polysomes and can activate the translation of reporter mRNAs in vivo [1].
Here, we show that ePABP is also expressed in X. laevis testis, suggesting a more general role for ePABP in gametogenesis [1].
Finally, we show that the activity of both PABP1 and ePABP increases during oocyte maturation, when many mRNAs undergo polyadenylation [1].
We selected ePABP as an eRF3 binding protein in a two-hybrid screening of a X. laevis cDNA library and demonstrated that this protein is associated with translational complexes [2].

Biological context of MGC89376

We showed that PABP1 and ePABP proteins are both present during oogenesis and early development [2].

References

Embryonic poly(A)-binding protein stimulates translation in germ cells. Wilkie, G.S., Gautier, P., Lawson, D., Gray, N.K. Mol. Cell. Biol. (2005) [Pubmed]
Characterization of the poly(A) binding proteins expressed during oogenesis and early development of Xenopus laevis. Cosson, B., Couturier, A., Le Guellec, R., Moreau, J., Chabelskaya, S., Zhouravleva, G., Philippe, M. Biol. Cell (2002) [Pubmed]

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PAB4	Arabidopsis thaliana
AGOS_AGR122C	Ashbya gossypii ATCC 10895
PABPC1L	Bos taurus
PABPC1L	Canis lupus familiaris
pabpc1l	Danio rerio
PABPC1L	Gallus gallus
PABPC1L	Homo sapiens
KLLA0C17600g	Kluyveromyces lactis NRRL Y-1140
MGG_09505	Magnaporthe oryzae 70-15
Pabpc1l	Mus musculus
NCU04799	Neurospora crassa OR74A
PABPC1L	Pan troglodytes
Pabpc1l	Rattus norvegicus
PAB1	Saccharomyces cerevisiae S288c
pabp	Schizosaccharomyces pombe 972h-

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