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Gene Review

Pabpc1  -  poly(A) binding protein, cytoplasmic 1

Mus musculus

Synonyms: PABP, PABP-1, Pabp1, PabpI, Pabpl1, ...
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Disease relevance of Pabpc1

  • We report that infection of MT-2 cells with HIV-1 leads to efficient proteolysis of PABP [1].
  • Cleavage of PABP by viral proteases encoded by several picornaviruses and caliciviruses plays a role in the abrogation of cellular protein synthesis [1].
  • Purified HIV-1 and HIV-2 proteases cleave PABP1 directly at positions 237 and 477, separating the two first RNA-recognition motifs from the C-terminal domain of PABP [1].
  • HIV protease cleaves poly(A)-binding protein [1].
  • These findings indicate that some retroviruses may share with picornaviruses and caliciviruses the capacity to proteolyse PABP [1].

High impact information on Pabpc1


Biological context of Pabpc1

  • Second, mRNAs encoding somatic PABP isoform, PABP1, are present at high levels in meiotic and haploid spermatogenic cells [5].
  • This synergy is mediated via interactions between eIF4G (a component of the eIF4F cap binding complex) and poly(A) binding protein (PABP) [6].
  • Although inducers do not alter initiation factor modifications, characterization of their effect on mRNA translation provides evidence that this is mediated by the poly(A)-binding protein (PABP) [7].
  • The role of eIF4G during the initiation of protein synthesis was studied using mouse mammary carcinoma FM3A cells and FM4G cells that overproduce an N-terminally truncated form of eIF4G, which lacks the binding site of poly(A)-binding protein [8].

Anatomical context of Pabpc1

  • Most of the PABP1 message accumulated by growing oocytes decays during meiotic maturation with transcription resuming in two-cell embryos [9].
  • Three cDNAs encode for smooth muscle actin, one for fibronectin and one for polyadenylate binding protein [10].
  • These data suggest that the PABP plays a role in the accumulation of these 80 S ribosomal.mRNA complexes and may facilitate the formation of translationally active salt-stable ribosomes [7].
  • Immunoblotting demonstrates that the mRNAs in these 80 S ribosomal complexes do not contain bound PABP and that this protein is found to be almost exclusively associated with translating polysomes [7].

Other interactions of Pabpc1


Analytical, diagnostic and therapeutic context of Pabpc1


  1. HIV protease cleaves poly(A)-binding protein. Alvarez, E., Castelló, A., Menéndez-Arias, L., Carrasco, L. Biochem. J. (2006) [Pubmed]
  2. An embryonic poly(A)-binding protein (ePAB) is expressed in mouse oocytes and early preimplantation embryos. Seli, E., Lalioti, M.D., Flaherty, S.M., Sakkas, D., Terzi, N., Steitz, J.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  3. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Yadav, N., Lee, J., Kim, J., Shen, J., Hu, M.C., Aldaz, C.M., Bedford, M.T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Embryonic poly(A)-binding protein stimulates translation in germ cells. Wilkie, G.S., Gautier, P., Lawson, D., Gray, N.K. Mol. Cell. Biol. (2005) [Pubmed]
  5. The mouse gene encoding the testis-specific isoform of Poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes. Kleene, K.C., Mulligan, E., Steiger, D., Donohue, K., Mastrangelo, M.A. J. Mol. Evol. (1998) [Pubmed]
  6. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. Berlanga, J.J., Baass, A., Sonenberg, N. RNA (2006) [Pubmed]
  7. Inducers of erythroleukemic differentiation cause messenger RNAs that lack poly(A)-binding protein to accumulate in translationally inactive, salt-labile 80 S ribosomal complexes. Hensold, J.O., Barth-Baus, D., Stratton, C.A. J. Biol. Chem. (1996) [Pubmed]
  8. Increase in cap- and IRES-dependent protein synthesis by overproduction of translation initiation factor eIF4G. Hayashi, S., Nishimura, K., Fukuchi-Shimogori, T., Kashiwagi, K., Igarashi, K. Biochem. Biophys. Res. Commun. (2000) [Pubmed]
  9. RNA-binding proteins in mouse oocytes and embryos: expression of genes encoding Y box, DEAD box RNA helicase, and polyA binding proteins. Paynton, B.V. Dev. Genet. (1998) [Pubmed]
  10. Isolation of cDNAs from a mouse astroglial cell line by a subtracted cDNA library. Rhyner, T.A., Lecain, E., Mallet, J., Pessac, B. J. Neurosci. Res. (1990) [Pubmed]
  11. Translational repression of EF-1 alpha mRNA in vitro. Slobin, L.I., Rao, M.N. Eur. J. Biochem. (1993) [Pubmed]
  12. Stability of casein mRNA is ensured by structural interactions between the 3'-untranslated region and poly(A) tail via the HuR and poly(A)-binding protein complex. Nagaoka, K., Suzuki, T., Kawano, T., Imakawa, K., Sakai, S. Biochim. Biophys. Acta (2006) [Pubmed]
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