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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Gene Review

trol  -  terribly reduced optic lobes

Drosophila melanogaster

Synonyms: BcDNA:GM02481, CG12497, CG33675, CG33950, CG7981, ...
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High impact information on trol

  • We present here genetic interaction and phenotypic analysis showing that eve functions in the trol pathway to regulate the onset of neuroblast division in the larval CNS [1].
  • The quiescent optic lobe and thoracic neuroblasts affected by trolsd proliferate in a trol mutant background if they have been activated by a lack of the ana proliferation repressor, demonstrating that trolsd does not affect cellular viability, nor does trol represent a celltype-specific mitotic factor [2].
  • Finally, analyses of mutations in trol, hh, and ttv suggest that Trol affects Hh movement [3].
  • Here, we show that trol encodes the Drosophila homolog of Perlecan and regulates neuroblast division by modulating both FGF and Hh signaling [3].
  • Mutations in the Drosophila trol gene cause cell cycle arrest of neuroblasts in the larval brain [3].

Biological context of trol

  • In trol mutants, neuroblasts fail to exit G1 for S phase [4].
  • Additionally, genetic and molecular analysis reveals that an independent mutation which acts as a dominant enhancer of trol is also an allele of eve [5].
  • Drosophila homeobox gene eve enhances trol, an activator of neuroblast proliferation in the larval CNS [5].
  • Culture of trolsd CNSs with wildtype larval extract or ecdysone results in the defective neuroblast proliferation phenotype observed in trol mutants in vivo, while culture of wildtype CNSs with trolsd extract produces normal neuroblast proliferation [6].

Anatomical context of trol

  • Stem cell division in the Drosophila brain is controlled by trol, which is required for activation of proliferation by quiescent neuroblasts at the appropriate stage of larval development [5].
  • Expression of cyclin E or DP/E2F rescues the G1 arrest of trol mutant neuroblasts in the Drosophila larval central nervous system [7].

Other interactions of trol

  • These results suggest that trol and ana are components of a novel developmental pathway for the control of cell cycle activation in quiescent neuroblasts [2].


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