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Gene Review

MYCLP1  -  MYCL pseudogene 1

Homo sapiens

Synonyms: MYCL1P1, MYCL2, Protein L-Myc-2, V-myc myelocytomatosis viral oncogene homolog pseudogene 1, bHLHe38
 
 
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Disease relevance of MYCL2

  • RNase protection analysis of a panel of human normal and tumor tissues has revealed that MYCL2 is expressed almost exclusively in human adult normal testis; much lower levels of transcript were detected in one human lung adenocarcinoma [1].
 

High impact information on MYCL2

 

Biological context of MYCL2

  • Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2 [2].
  • This sequence is not the MYCL2 homology, previously mapped to the long arm of the X chromosome at q22-qter by Morton et al., as we located the MYCL2-processed gene in Xq22-23, using a panel containing a combination of hybrid DNA carrying different portions of the human X chromosome [2].
  • RNase protection assays and the 5' RACE protocol (Rapid Amplification of cDNA Ends) were used to address the localization of the transcription start site of the MYCL2 sense transcript and different putative promoters and transcription regulatory elements have been identified [1].
  • Mapping of MYCL2 by somatic cell hybrids places this sequence on the long arm of the X chromosome in bands q22----q28 [3].
  • This processed gene (MYCL2) was isolated by cross-hybridization to an oligonucleotide probe synthesized from the C-MYC (MYC) sequence in a highly conserved region of the myc gene family [3].
 

Anatomical context of MYCL2

  • This observation suggests a germ cell rather than somatic cell origin of the transcript and possible developmental regulation of MYCL2 [1].
 

Analytical, diagnostic and therapeutic context of MYCL2

References

  1. Testis-specific expression of the human MYCL2 gene. Robertson, N.G., Pomponio, R.J., Mutter, G.L., Morton, C.C. Nucleic Acids Res. (1991) [Pubmed]
  2. Mapping of the MYCL2 processed gene to Xq22-23 and identification of an additional L MYC-related sequence in Xq27.2. Redolfi, E., Pizzuti, A., Di Bacco, A., Susani, L., Labella, T., Affer, M., Montagna, C., Reinbold, R., Mumm, S., Vezzoni, P., Zucchi, I. FEBS Lett. (1999) [Pubmed]
  3. Mapping and characterization of an X-linked processed gene related to MYCL1. Morton, C.C., Nussenzweig, M.C., Sousa, R., Sorenson, G.D., Pettengill, O.S., Shows, T.B. Genomics (1989) [Pubmed]
 
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