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Gene Review

MYCL  -  v-myc avian myelocytomatosis viral...

Homo sapiens

Synonyms: BHLHE38, Class E basic helix-loop-helix protein 38, LMYC, MYCL1, Protein L-Myc, ...
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Disease relevance of MYCL1


High impact information on MYCL1

  • No significant increase in metastasis was observed in the lung adenocarcinomas that contained one or more 6-kilobase EcoRI alleles of the LMYC gene [6].
  • We identified one novel amplicon on chromosome 11q22, in addition to previously reported amplicons that include oncogenes MYCC, MYCL1 and previously identified amplification of chromosomal regions 6q21 and 3q26-27 [7].
  • Seven markers between D1S2843 (1p36.12) and MYCL1 (1p34.1), and 1 each at D1S484 (1q24.1), IGF2R-3 (6q26), and TP53 (17p13.1) were used [8].
  • In HCCs, LOH was detected most frequently at loci D1S2843 (1p36.1) (28.6%), D1S513 (1p34.3) (29.2%), and MYCL1 (1p34.1) (28.6%) [8].
  • Losses of MYCL and RB1 alleles were more pronounced in patients having concomitant field disease because 11 of 14 informative cases showed losses compared with 3 of 8 cases without field disease [9].

Biological context of MYCL1


Anatomical context of MYCL1


Other interactions of MYCL1

  • Among our findings, we identified sets of genes whose expression correlated with MYC, MYCN or MYCL1 amplification, with surprisingly little overlap among gene sets [13].
  • We found a significant difference in the numbers of gene loci hit by deletions muscle-invasive versus noninvasive tumors (P = 0.0000002), with the genes most often hit by deletions in muscle-invasive tumors being TP53, RB1, and MYCL [9].
  • Ten out of 40 (25%) samples showed MSI at a minimum of one locus using five different tetranucleotide repeat primers (HPRT1, HPRTII, MYCL1, RB, REN) [14].
  • Novel amplifications were identified, some encompassing oncogenes MYCL1, PDGFRA, KIT, and MYB not previously reported to show amplification in these tumors [15].
  • In metastatic tumours, amplification of ERBB gene was detected in three metastatic tumours (9.4%), and all of them had allelic deletion of the LMYC gene [16].

Analytical, diagnostic and therapeutic context of MYCL1


  1. Mapping and characterization of an X-linked processed gene related to MYCL1. Morton, C.C., Nussenzweig, M.C., Sousa, R., Sorenson, G.D., Pettengill, O.S., Shows, T.B. Genomics (1989) [Pubmed]
  2. Molecular evaluation of abnormalities of the short arm of chromosome 1 in neuroblastoma. Hunt, J.D., Tereba, A. Genes Chromosomes Cancer (1990) [Pubmed]
  3. Exclusion of the familial melanoma locus (MLM) from the PND/D1S47 and MYCL1 regions of chromosome arm 1p in 7 Australian pedigrees. Nancarrow, D.J., Palmer, J.M., Walters, M.K., Kerr, B.M., Hafner, G.J., Garske, L., McLeod, G.R., Hayward, N.K. Genomics (1992) [Pubmed]
  4. Coexisting amplifications of the chromosome 1p32 genes (PTPRF and MYCL1) encoding protein tyrosine phosphatase LAR and L-myc in a small cell lung cancer line. Harder, K.W., Saw, J., Miki, N., Jirik, F. Genomics (1995) [Pubmed]
  5. Allelotype and loss of heterozygosity around the L-myc gene locus in primary lung cancers. Mendoza, C., Sato, H., Hiyama, K., Ishioka, S., Isobe, T., Maeda, H., Hiyama, E., Inai, K., Yamakido, M. Lung Cancer (2000) [Pubmed]
  6. Activated protooncogenes in human lung tumors from smokers. Reynolds, S.H., Anna, C.K., Brown, K.C., Wiest, J.S., Beattie, E.J., Pero, R.W., Iglehart, J.D., Anderson, M.W. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  7. A comprehensive search for DNA amplification in lung cancer identifies inhibitors of apoptosis cIAP1 and cIAP2 as candidate oncogenes. Dai, Z., Zhu, W.G., Morrison, C.D., Brena, R.M., Smiraglia, D.J., Raval, A., Wu, Y.Z., Rush, L.J., Ross, P., Molina, J.R., Otterson, G.A., Plass, C. Hum. Mol. Genet. (2003) [Pubmed]
  8. An early lesion in hepatic carcinogenesis: loss of heterozygosity in human cirrhotic livers and dysplastic nodules at the 1p36-p34 region. Sun, M., Eshleman, J.R., Ferrell, L.D., Jacobs, G., Sudilovsky, E.C., Tuthill, R., Hussein, M.R., Sudilovsky, O. Hepatology (2001) [Pubmed]
  9. Allelic deletions of cell growth regulators during progression of bladder cancer. Primdahl, H., von der Maase, H., Christensen, M., Wolf, H., Orntoft, T.F. Cancer Res. (2000) [Pubmed]
  10. Testis-specific expression of the human MYCL2 gene. Robertson, N.G., Pomponio, R.J., Mutter, G.L., Morton, C.C. Nucleic Acids Res. (1991) [Pubmed]
  11. Microsatellite instability in multifocal urothelial carcinoma and effect on BAX and AXIN2. Walsh, A.M., Bailly, G.G., Bell, D.G., Norman, R.W., Gupta, R., Zayed, E., Nassar, B.A. The Canadian journal of urology. (2003) [Pubmed]
  12. Activation of MYCN in a case of non-Hodgkin's lymphoma. Finnegan, M.C., Hammond, D.W., Hancock, B.W., Goyns, M.H. Leuk. Lymphoma (1995) [Pubmed]
  13. Combined microarray analysis of small cell lung cancer reveals altered apoptotic balance and distinct expression signatures of MYC family gene amplification. Kim, Y.H., Girard, L., Giacomini, C.P., Wang, P., Hernandez-Boussard, T., Tibshirani, R., Minna, J.D., Pollack, J.R. Oncogene (2006) [Pubmed]
  14. Microsatellite instability of dinucleotide tandem repeat sequences is higher than trinucleotide, tetranucleotide and pentanucleotide repeat sequences in prostate cancer. Perinchery, G., Nojima, D., Goharderakhshan, R., Tanaka, Y., Alonzo, J., Dahiya, R. Int. J. Oncol. (2000) [Pubmed]
  15. High-resolution array-based comparative genomic hybridization of medulloblastomas and supratentorial primitive neuroectodermal tumors. McCabe, M.G., Ichimura, K., Liu, L., Plant, K., Bäcklund, L.M., Pearson, D.M., Collins, V.P. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  16. Alterations of oncogenes in metastatic tumours of human gastric carcinomas. Tsujino, T., Yoshida, K., Nakayama, H., Ito, H., Shimosato, T., Tahara, E. Br. J. Cancer (1990) [Pubmed]
  17. Reassignment of MYCL1 to human chromosome 1p34.3 by fluorescence in situ hybridization. Speleman, F., Van Camp, G., Van Roy, N. Cytogenet. Cell Genet. (1996) [Pubmed]
  18. Detection of occult high graded microsatellite instabilities in MMR gene mutation negative HNPCC tumors by addition of complementary marker analysis. Schiemann, U., Müller-Koch, Y., Gross, M., Glas, J., Baretton, G., Muders, M., Mussack, T., Holinski-Feder, E. Eur. J. Med. Res. (2005) [Pubmed]
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