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Gene Review

NFKBIE  -  nuclear factor of kappa light polypeptide...

Homo sapiens

Synonyms: I-kappa-B-epsilon, IKBE, IkB-E, IkB-epsilon, IkappaBepsilon, ...
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High impact information on NFKBIE

  • RESULTS: NF-kappaB activation triggered by PMA was not associated with the disappearance of immunoreactive IkappaBalpha, IkappaBbeta, IkappaBgamma, or IkappaBepsilon or with the dissociation of intact IkappaB from RelA [1].
  • Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon [2].
  • In addition, TGFbeta1 had no effect on IkappaBbeta and IkappaBepsilon levels [3].
  • Quantitative real-time PCR assays of eight characterized NF-kappaB-dependent genes and five genes not previously known to be NF-kappaB-dependent (Gro-beta and-gamma, IkappaBepsilon, interleukin (IL)-7R, and Naf-1) were used to determine whether they were directly or indirectly NF-kappaB regulated [4].
  • Nuclear export of IkappaBepsilon is mediated by a short leucine-rich nuclear export sequence (NES)-like sequence ((343)VLLPFDDLKI(352)), located between amino acids 343 and 352 [5].

Biological context of NFKBIE


Anatomical context of NFKBIE

  • In the present study, the NF-kappaB inhibitor I kappa B epsilon (IkappaBepsilon) has been analysed for somatic mutations in the same group of six patients already studied for IkappaBalpha mutations, as well as in cHL-derived cell lines [7].

Associations of NFKBIE with chemical compounds


Other interactions of NFKBIE


  1. Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation. Wilson, L., Szabó, C., Salzman, A.L. Gastroenterology (1999) [Pubmed]
  2. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson, B., Brautigan, D.L. J. Biol. Chem. (2006) [Pubmed]
  3. Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. Stuhlmeier, K.M., Pollaschek, C. J. Biol. Chem. (2005) [Pubmed]
  4. Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. Tian, B., Nowak, D.E., Jamaluddin, M., Wang, S., Brasier, A.R. J. Biol. Chem. (2005) [Pubmed]
  5. Characterization of the nuclear import and export functions of Ikappa B(epsilon). Lee, S.H., Hannink, M. J. Biol. Chem. (2002) [Pubmed]
  6. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. O'Connell, M.A., Bennett, B.L., Mercurio, F., Manning, A.M., Mackman, N. J. Biol. Chem. (1998) [Pubmed]
  7. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. Emmerich, F., Theurich, S., Hummel, M., Haeffker, A., Vry, M.S., Döhner, K., Bommert, K., Stein, H., Dörken, B. J. Pathol. (2003) [Pubmed]
  8. The kinetics of association and phosphorylation of IkappaB isoforms by IkappaB kinase 2 correlate with their cellular regulation in human endothelial cells. Heilker, R., Freuler, F., Vanek, M., Pulfer, R., Kobel, T., Peter, J., Zerwes, H.G., Hofstetter, H., Eder, J. Biochemistry (1999) [Pubmed]
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