The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

NFKBIE  -  nuclear factor of kappa light polypeptide...

Homo sapiens

Synonyms: I-kappa-B-epsilon, IKBE, IkB-E, IkB-epsilon, IkappaBepsilon, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on NFKBIE

  • RESULTS: NF-kappaB activation triggered by PMA was not associated with the disappearance of immunoreactive IkappaBalpha, IkappaBbeta, IkappaBgamma, or IkappaBepsilon or with the dissociation of intact IkappaB from RelA [1].
  • Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon [2].
  • In addition, TGFbeta1 had no effect on IkappaBbeta and IkappaBepsilon levels [3].
  • Quantitative real-time PCR assays of eight characterized NF-kappaB-dependent genes and five genes not previously known to be NF-kappaB-dependent (Gro-beta and-gamma, IkappaBepsilon, interleukin (IL)-7R, and Naf-1) were used to determine whether they were directly or indirectly NF-kappaB regulated [4].
  • Nuclear export of IkappaBepsilon is mediated by a short leucine-rich nuclear export sequence (NES)-like sequence ((343)VLLPFDDLKI(352)), located between amino acids 343 and 352 [5].
 

Biological context of NFKBIE

 

Anatomical context of NFKBIE

  • In the present study, the NF-kappaB inhibitor I kappa B epsilon (IkappaBepsilon) has been analysed for somatic mutations in the same group of six patients already studied for IkappaBalpha mutations, as well as in cHL-derived cell lines [7].
 

Associations of NFKBIE with chemical compounds

 

Other interactions of NFKBIE

References

  1. Protein kinase C-dependent activation of NF-kappaB in enterocytes is independent of IkappaB degradation. Wilson, L., Szabó, C., Salzman, A.L. Gastroenterology (1999) [Pubmed]
  2. Protein phosphatase 6 subunit with conserved Sit4-associated protein domain targets IkappaBepsilon. Stefansson, B., Brautigan, D.L. J. Biol. Chem. (2006) [Pubmed]
  3. Adenovirus-mediated gene transfer of mutated IkappaB kinase and IkappaBalpha reveal NF-kappaB-dependent as well as NF-kappaB-independent pathways of HAS1 activation. Stuhlmeier, K.M., Pollaschek, C. J. Biol. Chem. (2005) [Pubmed]
  4. Identification of direct genomic targets downstream of the nuclear factor-kappaB transcription factor mediating tumor necrosis factor signaling. Tian, B., Nowak, D.E., Jamaluddin, M., Wang, S., Brasier, A.R. J. Biol. Chem. (2005) [Pubmed]
  5. Characterization of the nuclear import and export functions of Ikappa B(epsilon). Lee, S.H., Hannink, M. J. Biol. Chem. (2002) [Pubmed]
  6. Role of IKK1 and IKK2 in lipopolysaccharide signaling in human monocytic cells. O'Connell, M.A., Bennett, B.L., Mercurio, F., Manning, A.M., Mackman, N. J. Biol. Chem. (1998) [Pubmed]
  7. Inactivating I kappa B epsilon mutations in Hodgkin/Reed-Sternberg cells. Emmerich, F., Theurich, S., Hummel, M., Haeffker, A., Vry, M.S., Döhner, K., Bommert, K., Stein, H., Dörken, B. J. Pathol. (2003) [Pubmed]
  8. The kinetics of association and phosphorylation of IkappaB isoforms by IkappaB kinase 2 correlate with their cellular regulation in human endothelial cells. Heilker, R., Freuler, F., Vanek, M., Pulfer, R., Kobel, T., Peter, J., Zerwes, H.G., Hofstetter, H., Eder, J. Biochemistry (1999) [Pubmed]
 
WikiGenes - Universities