The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

TACR2  -  tachykinin receptor 2

Canis lupus familiaris

Synonyms: NK-2R, SKR
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on Tacr2

  • Pretreatment of dogs with the NK-2 receptor antagonist, SR 48968 dose-dependently (1-10 mg/kg, p.o.) blocked the bronchoconstriction and respiratory responses to NKA challenge [1].
  • We studied the effects of the non-peptide NK-2 receptor antagonist SR48968 on canine colonic tone under resting conditions and after stimulation by the selective NK-2 receptor agonist [beta Ala8] neurokinin A-(4-10) [2].
  • In contrast, the selective NK2 receptor antagonist, R396 (10 microM) had no effect on the response to substance P [3].
  • A structure-activity study on neurokinin A and its C-terminal fragment NKA (4-10) has been performed in order to find selective agonists for the NK-2 receptor and identify chemical modifications suitable for protecting the peptides from degradation, while maintaining activity [4].
  • Local administration of the selective NK2 receptor agonist [beta-Ala8]-NKA-(4-10) depressed right atrial neuronal activity (27.3 +/- 6.4 to 14.7 +/- 3.8 impulses/min; P < 0. 05), whereas the selective NK3 receptor agonist senktide augmented such activity (18.9 +/- 6.4 to 53.1 +/- 12.0 impulses/min; P < 0.05) [5].
 

Analytical, diagnostic and therapeutic context of Tacr2

  • A variety of animal models have been used to profile activity of the tachykinins, particularly rodents and guinea pigs, but little information exists regarding methods to evaluate NK1- and NK2-receptor antagonist activity in dogs [6].

References

  1. Bronchoconstrictor and respiratory effects of neurokinin A in dogs. Sherwood, J.E., Mauser, P.J., Chapman, R.W. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
  2. A selective NK-2 antagonist blocks the increase of canine colonic tone and ileal contractions induced by the NK-2 selective receptor agonist, [beta Ala8] neurokinin A-(4-10). Basilisco, G., Phillips, S.F. Aliment. Pharmacol. Ther. (1994) [Pubmed]
  3. Characterization of the receptor mediating relaxation to substance P in canine middle cerebral artery: no evidence for involvement of substance P in neurogenically mediated relaxation. Stubbs, C.M., Waldron, G.J., Connor, H.E., Feniuk, W. Br. J. Pharmacol. (1992) [Pubmed]
  4. Structure-activity studies of neurokinin A. Rovero, P., Pestellini, V., Rhaleb, N.E., Dion, S., Rouissi, N., Tousignant, C., Télémaque, S., Drapeau, G., Regoli, D. Neuropeptides (1989) [Pubmed]
  5. Canine intrinsic cardiac neurons involved in cardiac regulation possess NK1, NK2, and NK3 receptors. Thompson, G.W., Hoover, D.B., Ardell, J.L., Armour, J.A. Am. J. Physiol. (1998) [Pubmed]
  6. A method to measure dual NK1/NK2-antagonist activity in dogs. Sherwood, J.E., Young, S., Selig, W., Schilling, A., Kreutner, W., Egan, R.W., Chapman, R.W. Journal of pharmacological and toxicological methods. (1998) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities