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Gene Review

TACR2  -  tachykinin receptor 2

Bos taurus

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Disease relevance of TACR2

  • The gene encoding the nonstructural protein (NSP) of O/SKR/2000 foot-and-mouth disease virus (FMDV) was constructed to express under the polyhedron promoter of baculovirus [1].
  • Comparison between FMDV O/SKR/2000 and other strains indicates that overall the number of amino acids appears to be conserved without any deletion in either NSP or capsid proteins, thus, suggesting that O/SKR/2000 evolved with minor difference from preexisting strains [2].
  • Although NK-2 receptor-mediated IP3 formation involves activation of a pertussis toxin-insensitive G-protein, increased cAMP production is largely a secondary response and can be at least partially attributed to autocrine stimulation by endogenously generated eicosanoids, particularly PGE2 [3].

High impact information on TACR2


Biological context of TACR2


Associations of TACR2 with chemical compounds


Analytical, diagnostic and therapeutic context of TACR2

  • Also, animal experiments indicated that O/SKR/2000 is not host-restricted and develop the clinical signs in the main susceptible livestock species (cattle and pigs) [8].


  1. Development of a foot-and-mouth disease NSP ELISA and its comparison with differential diagnostic methods. Kweon, C.H., Ko, Y.J., Kim, W.I., Lee, S.Y., Nah, J.J., Lee, K.N., Sohn, H.J., Choi, K.S., Hyun, B.H., Kang, S.W., Joo, Y.S., Lubroth, J. Vaccine (2003) [Pubmed]
  2. Molecular characterization of foot-and-mouth disease virus O/SKR/2000. Kweon, C.H., Ko, Y.J., Kim, W.I., Kwon, B.J., Hyun, B.H., Sohn, H.J., Choi, K.S., Shin, J.H. Virus Res. (2002) [Pubmed]
  3. Recombinant bovine neurokinin-2 receptor stably expressed in Chinese hamster ovary cells couples to multiple signal transduction pathways. Eistetter, H.R., Church, D.J., Mills, A., Godfrey, P.P., Capponi, A.M., Brewster, R., Schulz, M.F., Kawashima, E., Arkinstall, S.J. Cell Regul. (1991) [Pubmed]
  4. Characterization of a tachykinin peptide NK2 receptor transfected into murine fibroblast B82 cells. van Giersbergen, P.L., Shatzer, S.A., Henderson, A.K., Lai, J., Nakanishi, S., Yamamura, H.I., Buck, S.H. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  5. Signal transduction mechanisms of recombinant bovine neurokinin-2 receptor stably expressed in baby hamster kidney cells. Eistetter, H.R., Mills, A., Arkinstall, S.J. J. Cell. Biochem. (1993) [Pubmed]
  6. Desensitization of neurokinin A receptors expressed by B82 fibroblasts. Henderson, A.K., Roeske, W.R., Smith, T.L., Yamamura, H.I. Eur. J. Pharmacol. (1993) [Pubmed]
  7. Identification and antigenic site analysis of foot-and-mouth disease virus from pigs and cattle in Korea. Oem, J.K., Lee, K.N., Cho, I.S., Kye, S.J., Park, J.Y., Park, J.H., Kim, Y.J., Joo, Y.S., Song, H.J. J. Vet. Sci. (2005) [Pubmed]
  8. Comparison and analysis of the complete nucleotide sequence of foot-and-mouth disease viruses from animals in Korea and other PanAsia strains. Oem, J.K., Lee, K.N., Cho, I.S., Kye, S.J., Park, J.H., Joo, Y.S. Virus Genes (2004) [Pubmed]
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