The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

Tacr2  -  tachykinin receptor 2

Rattus norvegicus

Synonyms: NK-2 receptor, NK-2R, Neurokinin A receptor, SKR, Substance-K receptor, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Tacr2


Psychiatry related information on Tacr2


High impact information on Tacr2

  • Results: Cholera toxin-induced water and electrolyte secretion was inhibited by the substance P antagonists and the NK-1 and NK-2 receptor antagonists, but not by the NK-3 receptor antagonist or by pretreatment with capsaicin [7].
  • Thus, C-terminal truncation allows the NK-2 receptor to signal sustained MAP kinase activation, cell growth and transformation by a Ras- and PKC-independent mechanism [8].
  • This conclusion was more directly confirmed by an additional chimeric formation in which the introduction of the above middle portion of SPR into the corresponding region of SKR conferred a high affinity binding to substance P [9].
  • NK1-R was detected in myenteric and submucosal neurons and in interstitial cells of Cajal. NK2-R was localized to circular and longitudinal muscle cells and to nerve endings in the plexuses [10].
  • In naive animals the prolonged VRP evoked following single shock C-fiber stimulation was significantly antagonized by the NMDA receptor antagonist D-AP5 and the NK2 receptor antagonist MEN, 10376 but not by the NK1 receptor antagonists CP-96,345 or RP,67580 [11].

Chemical compound and disease context of Tacr2


Biological context of Tacr2


Anatomical context of Tacr2


Associations of Tacr2 with chemical compounds

  • Uterine NK2R mRNA levels were not altered by any steroid treatment [18].
  • OBJECTIVES: Present experiments were undertaken to study the influence of peptide NK-1 and NK-2 receptor agonists and antagonists as well as substance P and neurokinin A (the natural ligands for these tachykinin receptors) on vasopressin (AVP) secretion from the rat hypothalamo-neurohypophysial (HN) system in vitro [19].
  • We have now compared in F344 and BDE rats the airway effects of the tachykinins SP and NKA with those of specific NK1 and NK2 receptor agonists and have studied the effect of potent and specific nonpeptide NK1 and NK2 receptor antagonists on NKA-induced airway effects [20].
  • Doxantrazole (5 mg/kg intraperitoneally (i.p.)), a mast cell stabilizer, and SR 140333 (1 mg/kg i.p.) and MEN 11420 (0.1 mg/kg intravenously), respectively NK1 and NK2 receptor antagonists, were administered before GD [21].
  • 4. These results suggest that the induction, but not the maintenance, of cutaneous mechanical allodynia in flexor motoneurones is NK receptor dependent, with cutaneous C fibre conditioning inputs acting via NK1 and muscle C fibre conditioning inputs via NK2 receptor subtypes [22].

Regulatory relationships of Tacr2


Other interactions of Tacr2


Analytical, diagnostic and therapeutic context of Tacr2


  1. Relationship between overexpression of NK-1R, NK-2R and intestinal mucosal damage in acute necrotizing pancreatitis. Shi, X., Gao, N.R., Guo, Q.M., Yang, Y.J., Huo, M.D., Hu, H.L., Friess, H. World J. Gastroenterol. (2003) [Pubmed]
  2. Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation. Sluka, K.A., Milton, M.A., Willis, W.D., Westlund, K.N. Br. J. Pharmacol. (1997) [Pubmed]
  3. Effect of nepadutant, a neurokinin 2 tachykinin receptor antagonist, on immediate-early gene expression after trinitrobenzenesulfonic acid-induced colitis in the rat. Birder, L.A., Kiss, S., de Groat, W.C., Lecci, A., Maggi, C.A. J. Pharmacol. Exp. Ther. (2003) [Pubmed]
  4. Inducible nitric oxide synthase evoked nitric oxide counteracts capsaicin-induced airway smooth muscle contraction, but exacerbates plasma extravasation. Li, P.C., Shaw, C.F., Kuo, T.F., Chien, C.T. Neurosci. Lett. (2005) [Pubmed]
  5. The mechanism by which epinastine stops an adenosine analog from contracting BDE rat airways. Meade, C.J. Am. J. Respir. Crit. Care Med. (1998) [Pubmed]
  6. A dose-response analysis of intra-raphe tachykinin-induced hyperactivity. Paris, J.M., Lorens, S.A. J. Pharmacol. Exp. Ther. (1989) [Pubmed]
  7. Neurokinin 1 and 2 receptors mediate cholera toxin secretion in rat jejunum. Turvill, J.L., Connor, P., Farthing, M.J. Gastroenterology (2000) [Pubmed]
  8. Truncated, desensitization-defective neurokinin receptors mediate sustained MAP kinase activation, cell growth and transformation by a Ras-independent mechanism. Alblas, J., van Etten, I., Moolenaar, W.H. EMBO J. (1996) [Pubmed]
  9. Delineation of structural domains involved in the subtype specificity of tachykinin receptors through chimeric formation of substance P/substance K receptors. Yokota, Y., Akazawa, C., Ohkubo, H., Nakanishi, S. EMBO J. (1992) [Pubmed]
  10. Characterization of antisera specific to NK1, NK2, and NK3 neurokinin receptors and their utilization to localize receptors in the rat gastrointestinal tract. Grady, E.F., Baluk, P., Böhm, S., Gamp, P.D., Wong, H., Payan, D.G., Ansel, J., Portbury, A.L., Furness, J.B., McDonald, D.M., Bunnett, N.W. J. Neurosci. (1996) [Pubmed]
  11. Injury-induced plasticity of spinal reflex activity: NK1 neurokinin receptor activation and enhanced A- and C-fiber mediated responses in the rat spinal cord in vitro. Thompson, S.W., Dray, A., Urban, L. J. Neurosci. (1994) [Pubmed]
  12. Receptor subtypes involved in tachykinin-mediated edema formation. Alves, R.V., Campos, M.M., Santos, A.R., Calixto, J.B. Peptides (1999) [Pubmed]
  13. Characterization of neurogenic inflammation in the airways of two highly inbred rat strains. Germonpré, P.R., Joos, G.F., Everaert, E., Kips, J.C., Pauwels, R.A. Am. J. Respir. Crit. Care Med. (1995) [Pubmed]
  14. Tachykinin-mediated modulation of the primary antibody response in rats: evidence for mediation by an NK-2 receptor. Eglezos, A., Andrews, P.V., Boyd, R.L., Helme, R.D. J. Neuroimmunol. (1991) [Pubmed]
  15. Characterization of tachykinin receptors mediating plasma extravasation and vasodilatation in normal and acutely inflamed knee joints of the rat. Lam, F.Y., Wong, M.C. Br. J. Pharmacol. (1996) [Pubmed]
  16. Expression and presence of septal neurokinin-2 receptors controlling hippocampal acetylcholine release during sensory stimulation in rat. Steinberg, R., Marco, N., Voutsinos, B., Bensaid, M., Rodier, D., Souilhac, J., Alonso, R., Oury-Donat, F., Le Fur, G., Soubrie, P. Eur. J. Neurosci. (1998) [Pubmed]
  17. MEN 10,627, a novel polycyclic peptide antagonist of tachykinin NK2 receptors. Maggi, C.A., Astolfi, M., Giuliani, S., Goso, C., Manzini, S., Meini, S., Patacchini, R., Pavone, V., Pedone, C., Quartara, L. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  18. Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment. Pinto, F.M., Armesto, C.P., Magraner, J., Trujillo, M., Martín, J.D., Candenas, M.L. Endocrinology (1999) [Pubmed]
  19. Vasopressin release from the rat hypothalamo-neurohypophysial system: effects of tachykinin NK-1 and NK-2 receptors agonists and antagonists. Juszczak, M. Neuro Endocrinol. Lett. (2005) [Pubmed]
  20. In vivo characterization of the tachykinin receptors involved in the direct and indirect bronchoconstrictor effect of tachykinins in two inbred rat strains. Joos, G.F., Kips, J.C., Pauwels, R.A. Am. J. Respir. Crit. Care Med. (1994) [Pubmed]
  21. Chronic low-level administration of diquat increases the nociceptive response to gastric distension in rats: role of mast cells and tachykinin receptor activation. Anton, P.M., Theodorou, V., Fioramonti, J., Bueno, L. Pain (2001) [Pubmed]
  22. Involvement of neurokinin receptors in the induction but not the maintenance of mechanical allodynia in rat flexor motoneurones. Ma, Q.P., Woolf, C.J. J. Physiol. (Lond.) (1995) [Pubmed]
  23. Inhibition of acid-induced hyperaemia in the rat stomach by endogenous NK2 receptor ligands. Heinemann, A., Sattler, V., Jocic, M., Holzer, P. Neurosci. Lett. (1997) [Pubmed]
  24. Tissue distribution and quantitation of the mRNAs for three rat tachykinin receptors. Tsuchida, K., Shigemoto, R., Yokota, Y., Nakanishi, S. Eur. J. Biochem. (1990) [Pubmed]
  25. Effect of a non-peptide NK-2 tachykinin receptor antagonist on LH, FSH, and prolactin release by rat hemipituitaries in vitro. Debeljuk, L., Bandera, R., Bartke, A. J. Physiol. Pharmacol. (1997) [Pubmed]
  26. Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain. Chardenot, P., Roubert, C., Galiègue, S., Casellas, P., Le Fur, G., Soubrié, P., Oury-Donat, F. Mol. Pharmacol. (2002) [Pubmed]
  27. Airway hyperresponsiveness to bradykinin induced by allergen challenge in actively sensitised Brown Norway rats. Ellis, K.M., Cannet, C., Mazzoni, L., Fozard, J.R. Naunyn Schmiedebergs Arch. Pharmacol. (2004) [Pubmed]
  28. Pharmacological profile of a high affinity dipeptide NK1 receptor antagonist, FK888. Fujii, T., Murai, M., Morimoto, H., Maeda, Y., Yamaoka, M., Hagiwara, D., Miyake, H., Ikari, N., Matsuo, M. Br. J. Pharmacol. (1992) [Pubmed]
  29. Pharmacological characteristics of tachykinin receptors mediating acetylcholine release from neonatal rat spinal cord. Suzuki, H., Yoshioka, K., Maehara, T., Hagan, R.M., Nakanishi, S., Otsuka, M. Eur. J. Pharmacol. (1993) [Pubmed]
  30. Inhibitory effects of tachykinin receptor antagonists on thermally induced inflammatory reactions in a rat model. Löfgren, O., Qi, Y., Lundeberg, T. Burns : journal of the International Society for Burn Injuries. (1999) [Pubmed]
  31. Effect of celiac ganglionectomy on tachykinin innervation, receptor distribution and intestinal responses in the rat. Ouyang, A., Zimmerman, K., Wong, K.L., Sharp, D., Reynolds, J.C. J. Auton. Nerv. Syst. (1996) [Pubmed]
WikiGenes - Universities