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Gene Review

TkR86C  -  Tachykinin-like receptor at 86C

Drosophila melanogaster

Synonyms: CG6515, DmNTLR, Dmel\CG6515, NKD, NKD12, ...
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High impact information on Takr86C

  • We found 35 neuropeptide receptor genes in the honey bee (44 in Drosophila) and two genes, coding for leucine-rich repeats-containing protein hormone GPCRs (4 in Drosophila) [1].
  • In situ hybridization experiments demonstrate that NKD is expressed in the central nervous system, as well as in subsets of neurons in each segment of the developing ventral ganglia [2].
  • Interestingly, NKD mRNA is detected at very early stages of Drosophila embryonic development (3 h) and reaches the highest level of expression at 12-16 h, a time which correlates with the period of major neuronal development [2].
  • Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides [3].
  • In addition, we show that the proneural protein atonal, in association with daughterless, transactivates the NKD promoter in Schneider S2 cells via the proximal E box NKDE2 [4].

Biological context of Takr86C

  • In the fifth, sixth and seventh transmembrane regions the deduced amino acid sequence of LTKR exhibits 79% sequence identity to the DTKR receptor and 54% to that of NKD [5].

Other interactions of Takr86C


  1. A review of neurohormone GPCRs present in the fruitfly Drosophila melanogaster and the honey bee Apis mellifera. Hauser, F., Cazzamali, G., Williamson, M., Blenau, W., Grimmelikhuijzen, C.J. Prog. Neurobiol. (2006) [Pubmed]
  2. NKD, a developmentally regulated tachykinin receptor in Drosophila. Monnier, D., Colas, J.F., Rosay, P., Hen, R., Borrelli, E., Maroteaux, L. J. Biol. Chem. (1992) [Pubmed]
  3. Widely distributed Drosophila G-protein-coupled receptor (CG7887) is activated by endogenous tachykinin-related peptides. Birse, R.T., Johnson, E.C., Taghert, P.H., Nässel, D.R. J. Neurobiol. (2006) [Pubmed]
  4. Dual organisation of the Drosophila neuropeptide receptor NKD gene promoter. Rosay, P., Colas, J.F., Maroteaux, L. Mech. Dev. (1995) [Pubmed]
  5. A putative tachykinin receptor in the cockroach brain: molecular cloning and analysis of expression by means of antisera to portions of the receptor protein. Johard, H.A., Muren, J.E., Nichols, R., Larhammar, D.S., Nässel, D.R. Brain Res. (2001) [Pubmed]
  6. Cloning and transcriptional expression of a leucokinin-like peptide receptor from the southern cattle tick, Boophilus microplus (Acari: Ixodidae). Holmes, S.P., He, H., Chen, A.C., lvie, G.W., Pietrantonio, P.V. Insect Mol. Biol. (2000) [Pubmed]
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