Chemical Compound Review:
Saredutant N-[(2R)-4-(4-acetamido-4- phenyl-1...
Synonyms:
CHEMBL308148, SureCN185911, CHEBI:215369, AC1L2XTE, LS-25204, ...
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- Use of non-peptide tachykinin receptor antagonists to substantiate the involvement of NK1 and NK2 receptors in a spinal nociceptive reflex in the rat. Picard, P., Boucher, S., Regoli, D., Gitter, B.D., Howbert, J.J., Couture, R. Eur. J. Pharmacol. (1993)
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- Tachykinins contract the circular muscle of the human esophageal body in vitro via NK2 receptors. Huber, O., Bertrand, C., Bunnett, N.W., Pellegrini, C.A., Nadel, J.A., Debas, H.T., Geppetti, P. Gastroenterology (1993)
- Interaction of Met297 in the seventh transmembrane segment of the tachykinin NK2 receptor with neurokinin A. Labrou, N.E., Bhogal, N., Hurrell, C.R., Findlay, J.B. J. Biol. Chem. (2001)
- Expression profile and up-regulation of PRAX-1 mRNA by antidepressant treatment in the rat brain. Chardenot, P., Roubert, C., Galiègue, S., Casellas, P., Le Fur, G., Soubrié, P., Oury-Donat, F. Mol. Pharmacol. (2002)
- Airway hyperresponsiveness to cigarette smoke in ovalbumin-sensitized guinea pigs. Wu, Z.X., Zhou, D., Chen, G., Lee, L.Y. Am. J. Respir. Crit. Care Med. (2000)
- Involvement of tachykinin NK3 receptors in citric acid-induced cough and bronchial responses in guinea pigs. Daoui, S., Cognon, C., Naline, E., Emonds-Alt, X., Advenier, C. Am. J. Respir. Crit. Care Med. (1998)
- Receptor subtypes involved in tachykinin-mediated edema formation. Alves, R.V., Campos, M.M., Santos, A.R., Calixto, J.B. Peptides (1999)
- Involvement of tachykinin receptors (NK1 and NK2) in sodium metabisulfite-induced airway effects. Sakamoto, T., Tsukagoshi, H., Barnes, P.J., Chung, K.F. Am. J. Respir. Crit. Care Med. (1994)
- Endogenous nitric oxide inhibits bronchoconstriction induced by cold-air inhalation in guinea pigs: role of kinins. Yoshihara, S., Nadel, J.A., Figini, M., Emanueli, C., Pradelles, P., Geppetti, P. Am. J. Respir. Crit. Care Med. (1998)
- Identification of residues involved in ligand binding to the neurokinin-2 receptor. Huang, R.R., Vicario, P.P., Strader, C.D., Fong, T.M. Biochemistry (1995)
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- Role of tachykinin NK2-receptor activation in the allergen-induced late asthmatic reaction, airway hyperreactivity and airway inflammatory cell influx in conscious, unrestrained guinea-pigs. Schuiling, M., Zuidhof, A.B., Meurs, H., Zaagsma, J. Br. J. Pharmacol. (1999)
- The role of spinal neurokinin-2 receptors in the processing of nociceptive information from the joint and in the generation and maintenance of inflammation-evoked hyperexcitability of dorsal horn neurons in the rat. Neugebauer, V., Rumenapp, P., Schaible, H.G. Eur. J. Neurosci. (1996)
- Molecular determinants of peptide and nonpeptide NK-2 receptor antagonists binding sites of the human tachykinin NK-2 receptor by site-directed mutagenesis. Giolitti, A., Cucchi, P., Renzetti, A.R., Rotondaro, L., Zappitelli, S., Maggi, C.A. Neuropharmacology (2000)
- Chronic smoking enhances tachykinin synthesis and airway responsiveness in guinea pigs. Kwong, K., Wu, Z.X., Kashon, M.L., Krajnak, K.M., Wise, P.M., Lee, L.Y. Am. J. Respir. Cell Mol. Biol. (2001)
- Neurokinin B induces oedema formation in mouse lung via tachykinin receptor-independent mechanisms. Grant, A.D., Akhtar, R., Gerard, N.P., Brain, S.D. J. Physiol. (Lond.) (2002)
- Further identification of neurokinin receptor types and mechanisms of calcium signaling evoked by neurokinins in the murine neuroblastoma C1300 cell line. Fukuhara, S., Mukai, H., Kako, K., Nakayama, K., Munekata, E. J. Neurochem. (1996)
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- Effect of neurokinins on canine prostate cell physiology. Walden, P.D., Marinese, D., Srinivasan, D., Tzoumaka, E., Syyong, H.T., Ford, A.P., Bhattacharya, A. Prostate (2005)
- PAR-2 agonists induce contraction of murine small intestine through neurokinin receptors. Zhao, A., Shea-Donohue, T. Am. J. Physiol. Gastrointest. Liver Physiol. (2003)
- Role of NK1 and NK2 receptors in mouse gastric mechanical activity. Mulè, F., Amato, A., Vannucchi, M.G., Faussone-Pellegrini, M.S., Serio, R. Br. J. Pharmacol. (2006)
- Analysis of the inflammatory response induced by substance P in the mouse pleural cavity. Fröde-Saleh, T.S., Calixto, J.B., Medeiros, Y.S. Peptides (1999)
- In vitro characterization of tachykinin NK2-receptors modulating motor responses of human colonic muscle strips. Croci, T., Aureggi, G., Manara, L., Emonds-Alt, X., Le Fur, G., Maffrand, J.P., Mukenge, S., Ferla, G. Br. J. Pharmacol. (1998)
- Characterization of NK3 receptors in rabbit isolated iris sphincter muscle. Medhurst, A.D., Parsons, A.A., Roberts, J.C., Hay, D.W. Br. J. Pharmacol. (1997)
- Postjunctional inhibitory effect of the NK2 receptor antagonist, SR 48968, on sensory NANC bronchoconstriction in the guinea-pig. Lou, Y.P., Lee, L.Y., Satoh, H., Lundberg, J.M. Br. J. Pharmacol. (1993)
- Role of tachykinins in castor oil diarrhoea in rats. Croci, T., Landi, M., Emonds-Alt, X., Le Fur, G., Maffrand, J.P., Manara, L. Br. J. Pharmacol. (1997)
- Respiratory actions of tachykinins in the nucleus of the solitary tract: characterization of receptors using selective agonists and antagonists. Mazzone, S.B., Geraghty, D.P. Br. J. Pharmacol. (2000)
- Characterization of the antibronchoconstrictor activity of MEN 11420, a tachykinin NK2 receptor antagonist, in guinea-pigs. Tramontana, M., Patacchini, R., Giuliani, S., Lippi, A., Lecci, A., Santicioli, P., Criscuoli, M., Maggi, C.A. Eur. J. Pharmacol. (1998)