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Gene Review:

NRAP - nebulin-related anchoring protein

Homo sapiens

Synonyms: N-RAP, Nebulin-related-anchoring protein

Neidhart, M. et al., Luo, G. et al.

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Disease relevance of NRAP

Soluble CD146 was measured by competitive enzyme-linked immunosorbent assay in synovial fluids of 3 healthy individuals and 7 cadavers (controls), as wells as in patients with traumatic joint injury (n = 10), osteoarthritis (OA; n = 10), psoriatic arthritis (PsA; n = 10), other non-RA polyarthritis (NRAP; n = 10), and RA (n = 31) [1].

High impact information on NRAP

Comparative analysis of the mouse and human genomes indicates that the NRAP gene is located in regions of conserved synteny between the two species [2].
We mapped the NRAP gene to mouse chromosome 19 using interspecific crosses and to human chromosome 10 using radiation hybrid panels [2].

Biological context of NRAP

Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes [2].

Anatomical context of NRAP

RESULTS: Compared with controls (mean +/- SD 10 +/- 2 ng/ml), significantly elevated synovial fluid levels of soluble CD146 were detected in patients with OA, PsA, and RA (17 +/- 7, 21 +/- 11, and 39 +/- 16 ng/ml, respectively; P < 0.02-0.001), but not in patients with traumatic joint injury or NRAP [1].

References

Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis. Neidhart, M., Wehrli, R., Brühlmann, P., Michel, B.A., Gay, R.E., Gay, S. Arthritis Rheum. (1999) [Pubmed]
Mapping of the gene (NRAP) encoding N-RAP in the mouse and human genomes. Luo, G., Leroy, E., Kozak, C.A., Polymeropoulos, M.H., Horowits, R. Genomics (1997) [Pubmed]

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NRAP	Bos taurus
NRAP	Canis lupus familiaris
NRAP	Gallus gallus
NRAP	Macaca mulatta
Nrap	Mus musculus
NRAP	Pan troglodytes
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nrap	Xenopus (Silurana) tropicalis

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