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Gene Review

MCAM  -  melanoma cell adhesion molecule

Homo sapiens

Synonyms: CD146, Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, MUC18, Melanoma cell adhesion molecule, ...
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Disease relevance of MCAM


High impact information on MCAM

  • The sequence is most similar to MUC18, reported as a tumor progression marker in human melanoma [6].
  • The cell surface glycoprotein MUC18, a member of the immunoglobulin superfamily and homologous to several cell adhesion molecules, is associated with tumor progression and the development of metastasis in human malignant melanoma [7].
  • Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains [7].
  • Sequencing of the putative MUC18 promoter region revealed a G + C-rich promoter lacking conventional TATA and CAAT boxes [7].
  • These elements may contribute to the differential regulation of the MUC18 gene in normal and malignant tissues and suggest a role for this putative adhesion molecule in neural crest cells during embryonic development [7].

Chemical compound and disease context of MCAM


Biological context of MCAM


Anatomical context of MCAM


Associations of MCAM with chemical compounds


Regulatory relationships of MCAM

  • Our results show that Mader is preferentially expressed on neurons and glial cells and that the adhesion protein MUC18/MCAM is mainly expressed on vasculature within the CNS [18].
  • Moreover, we found that CD146 dimerization was up-regulated by tumor conditional medium through the NF-kappa B pathway and down-regulated by mAb AA98 [19].

Other interactions of MCAM


Analytical, diagnostic and therapeutic context of MCAM


  1. Endothelin-1 upregulates MCAM in melanocytes. Mangahas, C.R., dela Cruz, G.V., Schneider, R.J., Jamal, S. J. Invest. Dermatol. (2004) [Pubmed]
  2. Cyclic AMP enhances the expression of an extravillous trophoblast marker, melanoma cell adhesion molecule, in choriocarcinoma cell JEG3 and human chorionic villous explant cultures. Higuchi, T., Fujiwara, H., Egawa, H., Sato, Y., Yoshioka, S., Tatsumi, K., Itoh, K., Maeda, M., Fujita, J., Fujii, S. Mol. Hum. Reprod. (2003) [Pubmed]
  3. Fully human antibodies to MCAM/MUC18 inhibit tumor growth and metastasis of human melanoma. Mills, L., Tellez, C., Huang, S., Baker, C., McCarty, M., Green, L., Gudas, J.M., Feng, X., Bar-Eli, M. Cancer Res. (2002) [Pubmed]
  4. Phorbol ester and cyclic AMP-mediated regulation of the melanoma-associated cell adhesion molecule MUC18/MCAM. Rummel, M.M., Sers, C., Johnson, J.P. Cancer Res. (1996) [Pubmed]
  5. Influence of MUC18/MCAM/CD146 expression on human melanoma growth and metastasis in SCID mice. Schlagbauer-Wadl, H., Jansen, B., Müller, M., Polterauer, P., Wolff, K., Eichler, H.G., Pehamberger, H., Konak, E., Johnson, J.P. Int. J. Cancer (1999) [Pubmed]
  6. Molecular cloning and expression of a novel adhesion molecule, SC1. Tanaka, H., Matsui, T., Agata, A., Tomura, M., Kubota, I., McFarland, K.C., Kohr, B., Lee, A., Phillips, H.S., Shelton, D.L. Neuron (1991) [Pubmed]
  7. Genomic organization of the melanoma-associated glycoprotein MUC18: implications for the evolution of the immunoglobulin domains. Sers, C., Kirsch, K., Rothbächer, U., Riethmüller, G., Johnson, J.P. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  8. Melanoma progression-associated glycoprotein MUC18/MCAM mediates homotypic cell adhesion through interaction with a heterophilic ligand. Johnson, J.P., Bar-Eli, M., Jansen, B., Markhof, E. Int. J. Cancer (1997) [Pubmed]
  9. The Role of N-Cadherin, MCAM and beta(3) integrin in Melanoma Progression, Proliferation, Migration and Invasion. Watson-Hurst, K., Becker, D. Cancer Biol. Ther. (2006) [Pubmed]
  10. Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis. Neidhart, M., Wehrli, R., Brühlmann, P., Michel, B.A., Gay, R.E., Gay, S. Arthritis Rheum. (1999) [Pubmed]
  11. HEMCAM, an adhesion molecule expressed by c-kit+ hemopoietic progenitors. Vainio, O., Dunon, D., Aïssi, F., Dangy, J.P., McNagny, K.M., Imhof, B.A. J. Cell Biol. (1996) [Pubmed]
  12. Regulation of the melanoma cell adhesion molecule gene in melanoma: modulation of mRNA synthesis by cyclic adenosine monophosphate, phorbol ester, and stem cell fFactor/c-kKit signaling. Karlen, S., Braathen, L.R. J. Invest. Dermatol. (1999) [Pubmed]
  13. Melanoma cell adhesion molecule (MCAM/CD146) is expressed on human luteinizing granulosa cells: enhancement of its expression by hCG, interleukin-1 and tumour necrosis factor-alpha. Yoshioka, S., Fujiwara, H., Higuchi, T., Yamada, S., Maeda, M., Fujii, S. Mol. Hum. Reprod. (2003) [Pubmed]
  14. Assignment of the human melanoma cell adhesion molecule gene (MCAM) to chromosome 11 band q23.3 by radiation hybrid mapping. Kuske, M.D., Johnson, J.P. Cytogenet. Cell Genet. (1999) [Pubmed]
  15. Outside-in signaling pathway linked to CD146 engagement in human endothelial cells. Anfosso, F., Bardin, N., Vivier, E., Sabatier, F., Sampol, J., Dignat-George, F. J. Biol. Chem. (2001) [Pubmed]
  16. MUC18/MCAM (CD146), an activation antigen of human T lymphocytes. Pickl, W.F., Majdic, O., Fischer, G.F., Petzelbauer, P., Faé, I., Waclavicek, M., Stöckl, J., Scheinecker, C., Vidicki, T., Aschauer, H., Johnson, J.P., Knapp, W. J. Immunol. (1997) [Pubmed]
  17. Markers of endothelial cell activation/injury: CD146 and thrombomodulin are related to adiponectin in kidney allograft recipients. Małyszko, J., Małyszko, J.S., Brzosko, S., Wołczynski, S., Myśliwiec, M. American journal of nephrology. (2005) [Pubmed]
  18. Melanoma-associated adhesion molecule MUC18/MCAM (CD146) and transcriptional regulator mader in normal human CNS. Schwarz, M.J., Müller, N., Körschenhausen, D., Kirsch, K.H., Penning, R., Ackenheil, M., Johnson, J.P., Hampel, H. Neuroimmunomodulation (1998) [Pubmed]
  19. Visualization of CD146 dimerization and its regulation in living cells. Bu, P., Zhuang, J., Feng, J., Yang, D., Shen, X., Yan, X. Biochim. Biophys. Acta (2007) [Pubmed]
  20. Adiponectin is related to CD146, a novel marker of endothelial cell activation/injury in chronic renal failure and peritoneally dialyzed patients. Malyszko, J., Malyszko, J.S., Brzosko, S., Wolczynski, S., Mysliwiec, M. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
  21. Is there a link between CD146, a novel adhesion molecule and other markers of endothelial dysfunction in nephrotic syndrome and continuous ambulatory peritoneal dialysis? Małyszko, J., Małyszko, J.S., Myśliwiec, M. Thromb. Res. (2005) [Pubmed]
  22. Expression of CD146 adhesion molecules (MUC18 or MCAM) in the thymic microenvironment. Seftalioğlu, A., Karakoç, L. Acta Histochem. (2000) [Pubmed]
  23. The role of CD146 (Mel-CAM) in biology and pathology. Shih, I.M. J. Pathol. (1999) [Pubmed]
  24. Expression of a human cell adhesion molecule, MUC18, in prostate cancer cell lines and tissues. Wu, G.J., Varma, V.A., Wu, M.W., Wang, S.W., Qu, P., Yang, H., Petros, J.A., Lim, S.D., Amin, M.B. Prostate (2001) [Pubmed]
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