Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Gene Review:

Mbs - Myosin binding subunit

Drosophila melanogaster

Synonyms: 0573/06, 0953/04, CG32156, CG5600, CG5891, ...

Mizuno, T. et al., Lee, A. et al., Tan, C. et al.

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on Mbs

The phosphatase activity is mainly regulated through phosphorylation of its myosin binding subunit MYPT [1].
Ectopic accumulation of phosphorylated MRLC was detected in lateral region of the leading edge cells, suggesting that the role of DMBS is to repress the activation of nonmuscle myosin II at the subcellular location for coordinated cell shape change [2].
The results indicate an important role for myosin phosphatase in morphogenesis [2].
Its regulatory myosin-binding subunit, MBS, is responsible for regulating the catalytic subunit in response to upstream signals and for determining the substrate specificity [2].
Mutations in the gene encoding the myosin binding subunit of this enzyme cause photoreceptors to drop out of the eye disc epithelium and move toward and through the optic stalk [3].

Analytical, diagnostic and therapeutic context of Mbs

Myosin binding subunit mutant cells continue to express apical epithelial markers and do not undergo ectopic apical constriction [3].

References

Roles of myosin phosphatase during Drosophila development. Tan, C., Stronach, B., Perrimon, N. Development (2003) [Pubmed]
Drosophila myosin phosphatase and its role in dorsal closure. Mizuno, T., Tsutsui, K., Nishida, Y. Development (2002) [Pubmed]
Excessive Myosin activity in mbs mutants causes photoreceptor movement out of the Drosophila eye disc epithelium. Lee, A., Treisman, J.E. Mol. Biol. Cell (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.