Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

Itlnb - intelectin b

Mus musculus

Synonyms: Intelectin-1b, Intelectin-2, Itln1b, Itln2

Pemberton, A.D. et al., Pemberton, A.D. et al.

Pemberton, Knight, Gamble, Colledge, Lee, Pierce, Miller, Pemberton, Knight, Wright, Miller,

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High impact information on Itlnb

In this study we sequence this novel lectin, termed intelectin-2, and compare expression levels during T. spiralis infection of resistant (BALB/c) with susceptible (C57BL/10) mouse strains [1].
Genomic PCR and Southern blotting confirmed that the intelectin-2 gene is absent from the C57BL/10 genome [1].
The changes observed at day 14/15 were of relevance to such mechanisms as lipid utilization and transport (increase in triacylglycerol lipase, and reduction in intestinal fatty acid binding protein) and innate immunity (appearance of intelectin-2) [2].

Biological context of Itlnb

The presence of intelectin-2 in resistant BALB/c mice, its absence from the susceptible C57BL/10 strain and the kinetics of its up-regulation during T. spiralis infection suggest that this novel lectin may serve a protective role in the innate immune response to parasite infection [1].

Analytical, diagnostic and therapeutic context of Itlnb

However, intelectin-2 transcripts and protein were absent, and immunohistochemistry negative when C57BL/10 mice were infected with T. spiralis [1].

References

Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice. Pemberton, A.D., Knight, P.A., Gamble, J., Colledge, W.H., Lee, J.K., Pierce, M., Miller, H.R. J. Immunol. (2004) [Pubmed]
Proteomic analysis of mouse jejunal epithelium and its response to infection with the intestinal nematode, Trichinella spiralis. Pemberton, A.D., Knight, P.A., Wright, S.H., Miller, H.R. Proteomics (2004) [Pubmed]

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