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Gene Review

amh  -  anti-Mullerian hormone

Danio rerio

Synonyms: SO:0000704
 
 
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High impact information on amh

  • AMH was detected in growing oocytes, the ovarian follicular layer and testicular Sertoli cells, similar to the mammalian pattern, suggesting a conserved role between zebrafish and mammalian AMH [1].
  • In adult ovaries, amh and cyp19a1a were expressed in granulosa cells surrounding the oocytes, and sox9b was expressed in a complementary fashion in the ooplasm of oocytes [2].
  • In adult testes, amh and sox9a were expressed in presumptive Sertoli cells [2].
  • In differentiated gonads of juveniles, amh showed a sexually dimorphic expression pattern [2].
  • In male mammalian embryos, Sox9 activates expression of Amh, which initiates the regression of the Mullerian ducts and inhibits the expression of aromatase (Cyp19a1), the enzyme that converts androgens to estrogens [2].

References

  1. Novel steroidogenic factor-1 homolog (ff1d) is coexpressed with anti-Mullerian hormone (AMH) in zebrafish. von Hofsten, J., Larsson, A., Olsson, P.E. Dev. Dyn. (2005) [Pubmed]
  2. Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Rodríguez-Marí, A., Yan, Y.L., Bremiller, R.A., Wilson, C., Cañestro, C., Postlethwait, J.H. Gene Expr. Patterns (2005) [Pubmed]
 
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