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Gene Review

sox9b  -  SRY (sex determining region Y)-box 9b

Danio rerio

Synonyms: SO:0000704, fb18d01, wu:fb18d01
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High impact information on sox9b


Biological context of sox9b

  • We have used a genotype-driven screen to isolate a mutation deleting sox9b function, and investigated its phenotype and genetic interactions with a sox9a null mutation [1].
  • By contrast, subfunction partitioning between zebrafish co-orthologs of tetrapod genes, such as sox9a and sox9b, can relax pleiotropy and reveal both early and late developmental gene functions [1].
  • During embryogenesis, sox9a and sox9b expression patterns are distinct but overlap in some regions of the brain, head skeleton, and fins [2].
  • Our analyses reveal that sox9b transcripts are present throughout the life-cycle of the zebrafish, but exhibit tissue-specific distribution during embryogenesis [4].


  1. A pair of Sox: distinct and overlapping functions of zebrafish sox9 co-orthologs in craniofacial and pectoral fin development. Yan, Y.L., Willoughby, J., Liu, D., Crump, J.G., Wilson, C., Miller, C.T., Singer, A., Kimmel, C., Westerfield, M., Postlethwait, J.H. Development (2005) [Pubmed]
  2. Two sox9 genes on duplicated zebrafish chromosomes: expression of similar transcription activators in distinct sites. Chiang, E.F., Pai, C.I., Wyatt, M., Yan, Y.L., Postlethwait, J., Chung, B. Dev. Biol. (2001) [Pubmed]
  3. The mother superior mutation ablates foxd3 activity in neural crest progenitor cells and depletes neural crest derivatives in zebrafish. Montero-Balaguer, M., Lang, M.R., Sachdev, S.W., Knappmeyer, C., Stewart, R.A., De La Guardia, A., Hatzopoulos, A.K., Knapik, E.W. Dev. Dyn. (2006) [Pubmed]
  4. Zebrafish sox9b is an early neural crest marker. Li, M., Zhao, C., Wang, Y., Zhao, Z., Meng, A. Dev. Genes Evol. (2002) [Pubmed]
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