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Gene Review

cyp19a1a  -  cytochrome P450, family 19, subfamily A,...

Danio rerio

Synonyms: Aromatase, CYP19a1, CYPXIX, Cytochrome P-450AROM, Cytochrome P450 19A1a, ...
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Disease relevance of cyp19a1a


High impact information on cyp19a1a

  • We isolated two cyp19 cDNAs, termed cyp19a and cyp19b, respectively, from zebrafish [2].
  • The expression of duplicated cyp19 genes at two different tissues highlights the evolutionary significance of maintaining two active genes on duplicated zebrafish chromosomes for specific functions in the ovary and the brain [2].
  • The early embryonic expression of P450aromB and P450aromA isoforms, and differences in developmental programming and estrogen regulation, imply independent regulatory mechanisms and unique functions during major morphogenetic and differentiative events [3].
  • Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system [4].
  • The brain cytochrome P450 aromatase (Aro-B) in zebrafish is expressed in radial glial cells and is strongly stimulated by estrogens (E(subscript)2(/subscript)) ; thus, it can be used in vivo as a biomarker of xenoestrogen effects on the central nervous system [4].

Biological context of cyp19a1a


Anatomical context of cyp19a1a


Associations of cyp19a1a with chemical compounds

  • Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development [3].
  • Here, we quantified seasonal changes in brain aromatase mRNA expression in the inter- and intrasexually dimorphic sonic motor nucleus (SMN) and in the preoptic area (POA) in males and females in relation to seasonal changes in circulating steroid hormone levels and reproductive behaviors [7].
  • The Cyp19 gene product aromatase converts testosterone into 17 beta-estradiol, and when inhibited leads to male to female sex reversal [9].
  • The effect of DES (0.01 microM) was similar to 1 microM E(2) (three- to four-fold higher than control), but BPA was less effective (<threefold increase at 10 microM). mRNA levels of the predominant ovarian isoform (P450aromA) were unchanged by estrogen [10].
  • The primary culture consisted of three major types of cells, presumably the fibroblasts, the thecal cells and the granulosa cells, according to the morphological features, histochemical staining for 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and RT-PCR for aromatase [11].

Other interactions of cyp19a1a


Analytical, diagnostic and therapeutic context of cyp19a1a

  • As a first step toward understanding estrogen's role in neurodevelopment, a PCR cloning strategy was used to isolate complementary DNAs encoding two distinct cytochrome P450 aromatase isoforms in adult zebrafish (Danio rerio) brain and ovary (termed P450aromB and P450aromA, respectively) [3].
  • On Northern blots, a single 4.4-kb transcript of the P450aromB subtype was identified in brain, and a 2.1-kb transcript of the P450aromA subtype in ovary, but RT-PCR showed a degree of overlapping expression [3].


  1. Effects of dibutylphthalate and ethynylestradiol on liver peroxisomes, reproduction, and development of zebrafish (Danio rerio). Ortiz-Zarragoitia, M., Trant, J.M., Cajaravillet, M.P. Environ. Toxicol. Chem. (2006) [Pubmed]
  2. Two Cyp19 (P450 aromatase) genes on duplicated zebrafish chromosomes are expressed in ovary or brain. Chiang, E.F., Yan, Y.L., Guiguen, Y., Postlethwait, J., Chung Bc, n.u.l.l. Mol. Biol. Evol. (2001) [Pubmed]
  3. Distinct cytochrome P450 aromatase isoforms in zebrafish (Danio rerio) brain and ovary are differentially programmed and estrogen regulated during early development. Kishida, M., Callard, G.V. Endocrinology (2001) [Pubmed]
  4. Assessment of xenoestrogens using three distinct estrogen receptors and the zebrafish brain aromatase gene in a highly responsive glial cell system. Le Page, Y., Scholze, M., Kah, O., Pakdel, F. Environ. Health Perspect. (2006) [Pubmed]
  5. Differential tissue distribution, developmental programming, estrogen regulation and promoter characteristics of cyp19 genes in teleost fish. Callard, G.V., Tchoudakova, A.V., Kishida, M., Wood, E. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  6. Phylogeny, expression and enzyme activity of zebrafish cyp19 (P450 aromatase) genes. Tong, S.K., Chiang, E.F., Hsiao, P.H., Chung, B. J. Steroid Biochem. Mol. Biol. (2001) [Pubmed]
  7. Seasonal plasticity of brain aromatase mRNA expression in glia: divergence across sex and vocal phenotypes. Forlano, P.M., Bass, A.H. J. Neurobiol. (2005) [Pubmed]
  8. Characterization and expression pattern of zebrafish Anti-Müllerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Rodríguez-Marí, A., Yan, Y.L., Bremiller, R.A., Wilson, C., Cañestro, C., Postlethwait, J.H. Gene Expr. Patterns (2005) [Pubmed]
  9. Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. von Hofsten, J., Olsson, P.E. Reprod. Biol. Endocrinol. (2005) [Pubmed]
  10. Estrogen and xenoestrogens upregulate the brain aromatase isoform (P450aromB) and perturb markers of early development in zebrafish (Danio rerio). Kishida, M., McLellan, M., Miranda, J.A., Callard, G.V. Comp. Biochem. Physiol. B, Biochem. Mol. Biol. (2001) [Pubmed]
  11. Gonadotropin regulation of activin betaA and activin type IIA receptor expression in the ovarian follicle cells of the zebrafish, Danio rerio. Pang, Y., Ge, W. Mol. Cell. Endocrinol. (2002) [Pubmed]
  12. Short-term exposure to low concentrations of the synthetic androgen methyltestosterone affects vitellogenin and steroid levels in adult male zebrafish (Danio rerio). Andersen, L., Goto-Kazeto, R., Trant, J.M., Nash, J.P., Korsgaard, B., Bjerregaard, P. Aquat. Toxicol. (2006) [Pubmed]
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