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Gene Review:

IFNA1 - interferon, alpha 1

Felis catus

McCaw, D.L. et al., Osterhaus, A.D. et al., Sandmeyer, L.S. et al., Riondato, F. et al., Taira, O. et al., et al.

Riondato, Gianella, Guglielmino, Cagnasso, Bo, Osterhaus, Fouchier, Kuiken,

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Disease relevance of IFNA1

The first of these studies has shown that pegylated interferon-alpha, a drug approved for human use, limits SARS-CoV replication and lung damage in experimentally infected macaques [1].
Low-dose interferon-alpha treatment for feline immunodeficiency virus infection [2].
Clinically ill feline leukemia virus (FeLV)-infected cats, treated with Staphylococcus protein A (SPA) or oral interferon alpha (IFN), or both, were compared with cats treated with saline (SAL) [3].
Effects of interferon alpha (INF-alpha) therapy on peripheral blood lymphocyte subsets from FIV and FeLV naturally infected cats [4].

High impact information on IFNA1

RESULTS: Interferon-alpha did not have cytotoxic effects on corneal epithelial cells at concentrations ranging from 10(2) to 10(6) IU of IFN-alpha/mL [5].
Expression of feline interferon-alpha subtypes in Esherichia coli, and their antiviral activity and animal species specificity [6].
Cloning of cDNAs encoding multiple subtypes of feline interferon-alpha from the feline epitherial cell line [7].
Reversal of feline leukemia virus infection by adoptive transfer of activated T lymphocytes, interferon alpha, and zidovudine [8].

References

The aetiology of SARS: Koch's postulates fulfilled. Osterhaus, A.D., Fouchier, R.A., Kuiken, T. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (2004) [Pubmed]
Low-dose interferon-alpha treatment for feline immunodeficiency virus infection. Pedretti, E., Passeri, B., Amadori, M., Isola, P., Di Pede, P., Telera, A., Vescovini, R., Quintavalla, F., Pistello, M. Vet. Immunol. Immunopathol. (2006) [Pubmed]
Immunomodulation therapy for feline leukemia virus infection. McCaw, D.L., Boon, G.D., Jergens, A.E., Kern, M.R., Bowles, M.H., Johnson, J.C. Journal of the American Animal Hospital Association. (2001) [Pubmed]
Effects of interferon alpha (INF-alpha) therapy on peripheral blood lymphocyte subsets from FIV and FeLV naturally infected cats. Riondato, F., Gianella, P., Guglielmino, R., Cagnasso, A., Bo, S. Vet. Res. Commun. (2003) [Pubmed]
Effects of interferon-alpha on cytopathic changes and titers for feline herpesvirus-1 in primary cultures of feline corneal epithelial cells. Sandmeyer, L.S., Keller, C.B., Bienzle, D. Am. J. Vet. Res. (2005) [Pubmed]
Expression of feline interferon-alpha subtypes in Esherichia coli, and their antiviral activity and animal species specificity. Taira, O., Suzuki, M., Takeuchi, Y., Aramaki, Y., Sakurai, I., Watanabe, T., Motokawa, K., Arai, S., Sato, H., Maehara, N. J. Vet. Med. Sci. (2005) [Pubmed]
Cloning of cDNAs encoding multiple subtypes of feline interferon-alpha from the feline epitherial cell line. Nagai, A., Taira, O., Ishikawa, M., Hiramatsu, K., Hohdatsu, T., Koyama, H., Arai, S., Sato, H., Nakano, K., Maehara, N. J. Vet. Med. Sci. (2004) [Pubmed]
Reversal of feline leukemia virus infection by adoptive transfer of activated T lymphocytes, interferon alpha, and zidovudine. Zeidner, N.S., Mathiason-DuBard, C.K., Hoover, E.A. Semin. Vet. Med. Surg. Small Anim. (1995) [Pubmed]

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