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Gene Review:

CXCL8 - interleukin 8

Felis catus

Bironaite, D. et al., Straubinger, R.K. et al., Hwang, C.Y. et al., Kubes, P. et al., Simpson, K.W. et al.

Kubes, Heit, van Marle, Johnston, Knight, Khan, Power,

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Disease relevance of IL8

Upregulation of IFN-gamma, IL-1 alpha, IL-1 beta, and IL-8 and marked hyperplasia of secondary lymphoid follicles are early consequences of H. pylori infection in cats [1].
Upregulation of IFN-gamma, IL-1 alpha, IL-1 beta, and IL-8 and increased severity of inflammatory infiltrates and fibrosis were observed in infected cats [1].
Gastritis scores of fundic tissues from clinically abnormal infected dogs were similar to that from noninfected dogs and evidence of upregulation of IL-1beta, IL-8, and TNF-alpha mRNA was not detected in gastric fundic tissues from clinically abnormal infected dogs [2].

High impact information on IL8

In addition, in vivo neutrophil adhesion and emigration out of the vasculature were severely reduced, and in vitro neutrophil chemotaxis from FIV-infected animals was significantly impaired in response to fMLP or IL-8 [3].
The mucosal inflammatory response was evaluated by light microscopy, and by RT-PCR of the pro-inflammatory cytokines IL-1alpha, IL-1beta, IL-8 and TNF-alpha in gastric mucosa [4].
One potential mechanism of apoptosis induced by benzene metabolites that has not been examined is the production of pro-apoptotic cytokines such as endothelial IL-8 from endothelial cells in bone marrow stroma [5].
In this study, we utilized HL-60 cells which are known to produce the endothelial form of IL-8 (elL-8) and human bone marrow endothelial cells (HBMEC) as model systems [5].
However, treatment with recombinant elL-8 failed to induce apoptosis in HL-60 cells as previously reported and antibodies to either IL-8 or CXCRI did not significantly abrogate benzene metabolite-induced apoptosis [5].

References

Quantitative evaluation of inflammatory and immune responses in the early stages of chronic Helicobacter pylori infection. Straubinger, R.K., Greiter, A., McDonough, S.P., Gerold, A., Scanziani, E., Soldati, S., Dailidiene, D., Dailide, G., Berg, D.E., Simpson, K.W. Infect. Immun. (2003) [Pubmed]
Prevalence and clinical characterization of gastric Helicobacter species infection of dogs and cats in Korea. Hwang, C.Y., Han, H.R., Youn, H.Y. J. Vet. Sci. (2002) [Pubmed]
In vivo impairment of neutrophil recruitment during lentivirus infection. Kubes, P., Heit, B., van Marle, G., Johnston, J.B., Knight, D., Khan, A., Power, C. J. Immunol. (2003) [Pubmed]
Helicobacter pylori infection in the cat: evaluation of gastric colonization, inflammation and function. Simpson, K.W., Strauss-Ayali, D., Straubinger, R.K., Scanziani, E., McDonough, P.L., Straubinger, A.F., Chang, Y.F., Esteves, M.I., Fox, J.G., Domeneghini, C., Arebi, N., Calam, J. Helicobacter (2001) [Pubmed]
Stimulation of endothelial IL-8 (eIL-8) production and apoptosis by phenolic metabolites of benzene in HL-60 cells and human bone marrow endothelial cells. Bironaite, D., Siegel, D., Moran, J.L., Weksler, B.B., Ross, D. Chem. Biol. Interact. (2004) [Pubmed]

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