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Gene Review:

LOC496393 - monoamine oxidase

Xenopus laevis

Fukumoto, T. et al., Grace, M.S. et al., Cahill, G.M. et al., Cahill, G.M. et al., Temple, J.G. et al.

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High impact information on LOC496393

This produces 5-methoxytryptamine, which is then deaminated by monoamine oxidase [amine:oxygen oxidoreductase (deaminating) (flavin-containing), EC 1.4.3.4], producing 5-methoxyindoleacetic acid and 5-methoxytryptophol [1].
RESULTS: A pharmacological screen implicated endogenous signaling through receptors R3 and R4 and the activity of monoamine oxidase (MAO) in the establishment of correct sidedness of asymmetric gene expression and of the viscera in Xenopus embryos [2].
The monoamine oxidase inhibitor pargyline (100 microM) caused a sixfold increase in melatonin release, and the serotonin precursor 5-hydroxy-L-tryptophan (100 microM) caused a 70-fold increase [3].
Deamination of 5-methoxytryptamine is inhibited by the monoamine oxidase inhibitor pargyline, such that 5-methoxyindoleacetic acid and 5-methoxytryptophol levels are decreased while levels of 5-methoxytryptamine are increased [4].
Effects of monoamine oxidase inhibitors and dopamine agonists on the behavior of mammal- and frog-eating snakes [5].

References

Retinal melatonin is metabolized within the eye of xenopus laevis. Cahill, G.M., Besharse, J.C. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
Serotonin signaling is a very early step in patterning of the left-right axis in chick and frog embryos. Fukumoto, T., Kema, I.P., Levin, M. Curr. Biol. (2005) [Pubmed]
Circadian regulation of melatonin in the retina of Xenopus laevis: limitation by serotonin availability. Cahill, G.M., Besharse, J.C. J. Neurochem. (1990) [Pubmed]
Melatonin deacetylation: retinal vertebrate class distribution and Xenopus laevis tissue distribution. Grace, M.S., Cahill, G.M., Besharse, J.C. Brain Res. (1991) [Pubmed]
Effects of monoamine oxidase inhibitors and dopamine agonists on the behavior of mammal- and frog-eating snakes. Temple, J.G., Barthalmus, G.T. Physiol. Behav. (1994) [Pubmed]

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